Results 31 to 40 of about 2,005,992 (360)
Peptide‐Guided Assembly of Repeat Protein Fragments [PDF]
Angewandte Chemie International Edition, 2018 AbstractHerein, we present the peptide‐guided assembly of complementary fragments of designed armadillo repeat proteins (dArmRPs) to create proteins that bind peptides not only with high affinity but also with good selectivity. We recently demonstrated that complementary N‐ and C‐terminal fragments of dArmRPs form high‐affinity complexes that resemble ...
Michel, Erich +2 more
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Biochemistry and Biophysics Reports, 2022 Amyloid beta (Aβ) proteins are produced from amyloid precursor protein cleaved by β- and γ-secretases, and are the main components of senile plaques pathologically found in Alzheimer's disease (AD) patient brains.
Dai Kato +5 more
doaj
CABS-dock web server for the flexible docking of peptides to proteins without prior knowledge of the binding site [PDF]
Nucleic Acids Research, 43 (W1): W419-W424, 2015, 2015 Protein-peptide interactions play a key role in cell functions. Their structural characterization, though challenging, is important for the discovery of new drugs. The CABS-dock web server provides an interface for modeling protein-peptide interactions using a highly efficient protocol for the flexible docking of peptides to proteins.
arxiv +1 more source
Modeling peptide fragmentation with dynamic Bayesian networks for peptide identification [PDF]
Bioinformatics, 2008 AbstractMotivation: Tandem mass spectrometry (MS/MS) is an indispensable technology for identification of proteins from complex mixtures. Proteins are digested to peptides that are then identified by their fragmentation patterns in the mass spectrometer.
William Stafford Noble +4 more
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Photocatalytic Redox Reactions for In‐Source Peptide Fragmentation [PDF]
Chemistry – A European Journal, 2009 AbstractIn‐source oxidation: In‐source photocatalytic redox reactions for inducing peptide fragmentation are achieved on a TiO2‐derived target plate during laser desorption ionization mass spectrometry in the presence of samples and glucose acting as both an electron donor and a hole conductor (see scheme).magnified imageIn‐source photocatalytic redox ...
Qiao, L. +6 more
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Antigenic Determinant of Trichosanthin Peptide Fragments
Immunopharmacology and Immunotoxicology, 1986 Purified plant protein, Trichosanthin (TCS), was partially digested with chymotrypsin to produce peptide fragments. Two large fragments, I and II, have been isolated and identified as C-terminal peptides located at sequence positions between 79-234 and 107-234. Their molecular weights determined by electrophoretic mobility on SDS gel were 16,000 and 14,
Zhen Yao +3 more
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High-resolution global peptide-protein docking using fragments-based PIPER-FlexPepDock
bioRxiv, 2017 Peptide-protein interactions contribute a significant fraction of the protein-protein interactome. Accurate modeling of these interactions is challenging due to the vast conformational space associated with interactions of highly flexible peptides with ...
Nawsad Alam +5 more
semanticscholar +1 more source
Oligomerization of amyloid Abeta peptides using hydrogen bonds and hydrophobicity forces [PDF]
Biophys. J. 87 (2004) 3657-3664, 2004 The 16-22 amino acid fragment of the beta-amyloid peptide associated with the Alzheimer's disease, Abeta, is capable of forming amyloid fibrils. Here we study the aggregation mechanism of Abeta(16-22) peptides by unbiased thermodynamic simulations at the atomic level for systems of one, three and six Abeta(16-22) peptides.
arxiv +1 more source
Effect of phenylalanine on the fragmentation of deprotonated peptides [PDF]
Journal of the American Society for Mass Spectrometry, 2002 The fragmentation reactions of a variety of deprotonated dipeptides and tripeptides containing phenylalanine have been studied using energy-resolved collision-induced dissociation, isotopic labeling and MS/MS/MS experiments. The benzyl a-group has a substantial effect on the fragmentation reactions observed.
openaire +3 more sources
A peptide filtering relation quantifies MHC class I peptide optimization.
PLoS Computational Biology, 2011 Major Histocompatibility Complex (MHC) class I molecules enable cytotoxic T lymphocytes to destroy virus-infected or cancerous cells, thereby preventing disease progression. MHC class I molecules provide a snapshot of the contents of a cell by binding to
Neil Dalchau +7 more
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