Results 31 to 40 of about 2,203,634 (375)

Fibrillisation of hydrophobically modified amyloid peptide fragments in an organic solvent [PDF]

, 2007
The self-assembly of a hydrophobically modified fragment of the amyloid beta(A beta) peptide has been studied in methanol. The peptide FFKLVFF is based on A beta(16-20) extended at the N terminus by two phenylalanine residues.
Castelletto, Valeria, Hamley, Ian W., Krysmann, M.J.   +2 more
core   +1 more source

Leveraging the multivalent p53 peptide-MdmX interaction to guide the improvement of small molecule inhibitors

Nature Communications, 2022
Peptide fragments derived from the interfaces of protein-protein interactions (PPIs) provide useful templates for designing small molecule PPI inhibitors.
Xiyao Cheng, Rong Chen, Ting Zhou, Bailing Zhang, Zichun Li, Meng Gao, Yongqi Huang, Huili Liu, Zhengding Su   +8 more
doaj   +1 more source

Water immersion increases the concentration of the immunoreactive N-terminal fragment of pro-atrial natriuretic factor in human plasma [PDF]

, 1988
Atrial natriuretic factor (ANF) N-terminal (ANF 1–98) and C-terminal (ANF 99–126) fragments were determined by radioimmunoassay in human plasma. Mean basal plasma ANF N-terminal concentrations in 9 healthy subjects were 461 ± 58 fmol/ml,significantly ...
Alexander L. Gerbes, Anderson, Angelika M. Vollmar, Arendt, Cantin, Epstein, Gerbes, Gerbes, Lang, Needleman, Ogihara, Pendergast, Schwartz, Sugawara, Sundsfjord, Thibault, Thibault   +16 more
core   +1 more source

Peptide‐Guided Assembly of Repeat Protein Fragments [PDF]

Angewandte Chemie International Edition, 2018
AbstractHerein, we present the peptide‐guided assembly of complementary fragments of designed armadillo repeat proteins (dArmRPs) to create proteins that bind peptides not only with high affinity but also with good selectivity. We recently demonstrated that complementary N‐ and C‐terminal fragments of dArmRPs form high‐affinity complexes that resemble ...
Michel, Erich, Plückthun, Andreas, Zerbe, Oliver   +2 more
openaire   +3 more sources

Comparative studies for amyloid beta degradation: “Neprilysin vs insulysin”, “monomeric vs aggregate”, and “whole Aβ40 vs its peptide fragments”

Biochemistry and Biophysics Reports, 2022
Amyloid beta (Aβ) proteins are produced from amyloid precursor protein cleaved by β- and γ-secretases, and are the main components of senile plaques pathologically found in Alzheimer's disease (AD) patient brains.
Dai Kato, Yoshiaki Takahashi, Haruto Iwata, Yusuke Hatakawa, Seon Hwa Lee, Tomoyuki Oe   +5 more
doaj  

Targeted online liquid chromatography electron capture dissociation mass spectrometry for the localization of sites of in vivo phosphorylation in human Sprouty2 [PDF]

, 2008
We demonstrate a strategy employing collision-induced dissociation for phosphopeptide discovery, followed by targeted electron capture dissociation (ECD) for site localization. The high mass accuracy and low background noise of the ECD mass spectra allow
Abbott K. L., Annan R. S., Beausoleil S. A., Chi A., Chi A., Collins M. O., Cooper H. J., DaSilva J., Edelson-Averbukh M., Gruhler A., Hanafusa H., Hunter A. P., Impagnatiello M.-A., Keil B., Kjeldsen F., Kocher T., Lao D.-H., Lao D.-H., Larsen M. R., Lee J., Li X., Li X., Lo T. L., Lopez L. L., Loyet K. M., McAlister G. C., Molina H., Olsen J. V., Olsen J. V., Pawson T., Pesavento J. J., Picotti P., Savitski M. M., Shi S. D. H., Stensballe A., Sweet S. M. M., Sweet S. M. M., Syka J. E., Tabb D. L., Williams D. K., Woodling K. A., Yu L.-R., Zubarev R. A.   +42 more
core   +1 more source

UV-induced ligand exchange in MHC class I protein crystals [PDF]

, 2009
High-throughput structure determination of protein−ligand complexes is central in drug development and structural proteomics. To facilitate such high-throughput structure determination we designed an induced replacement strategy.
Adams P. D., Bakker A. H., Bjorkman P. J., Blundell T. L., Borbulevych O. Y., Bosques C. J., Bourgeois D., Bouvier M., CCP4 (Collaborative Computational Project) N., Dudley M. E., Emsley P., Evans P. R., Frickel E. M., Garcia K. C., Grotenbreg G. M., Grotenbreg G. M., Hosken N., Kontopidis G., Lewinsohn D. A., Ljunggren H. G., Madden D. R., Moffat K., Murshudov G. N., Newman J., Oseroff C., Rodenko B., Schlichting I., Schumacher T. N., Speiser D. E., Sylwester A. W., Toebes M., Vriend G., Yewdell J. W.   +32 more
core   +1 more source

Modeling peptide fragmentation with dynamic Bayesian networks for peptide identification [PDF]

Bioinformatics, 2008
AbstractMotivation: Tandem mass spectrometry (MS/MS) is an indispensable technology for identification of proteins from complex mixtures. Proteins are digested to peptides that are then identified by their fragmentation patterns in the mass spectrometer.
William Stafford Noble, Jeff A. Bilmes, Sheila M. Reynolds, Aaron A. Klammer, Michael J. MacCoss   +4 more
openaire   +3 more sources

Method of treating endothelial dysfunction comprising administration of a thrombin peptide derivative [PDF]

, 2012
Endothelial dysfunction (ED) is associated with a number of diseases and disorders. Agonists of the non-proteolytically activated thrombin receptor can be used in methods to treat ED or ED-related diseases and disorders.Board of Regents, University of ...
Carney, Darrell H., Fossum, Theresa W., Olszewska-Pazdrak, Barbara   +2 more
core   +1 more source

Modulation of the FGF14:FGF14 homodimer interaction through short peptide fragments.

CNS and Neurological Disorders - Drug Targets, 2014
Fibroblast growth factor 14 (FGF14) is a member of the intracellular FGF (iFGFs) family and a functionally relevant component of the neuronal voltage-gated Na(+) (Nav) channel complex.
Syed R Ali, A. Shavkunov, Neli I. Panova, Svetla Stoilova-McPhie, F. Laezza   +4 more
semanticscholar   +1 more source