Results 31 to 40 of about 527,000 (340)
The N-terminal region of photocleavable peptides that bind HLA-DR1 determines the kinetics of fragment release. [PDF]
PLoS ONE, 2018 Major Histocompatibility Complex class II (MHC-II) molecules bind peptides and present them to receptors on CD4+ T cells as part of the immune system's surveillance of pathogens and malignancy.
Maria Pia Negroni, Lawrence J Stern
doaj +1 more source
Peptide and peptide-inspired checkpoint inhibitors: Protein fragments to cancer immunotherapy
Medicine in Drug Discovery, 2020 Immune system regained the attention of oncologists and has entered the mainstream for cancer therapy since the discovery of checkpoint antibodies targeting CTLA4 and PD-1 pathways.
Pottayil G. Sasikumar +1 more
doaj +1 more source
From Synthetic Fragments of Endogenous Three-Finger Proteins to Potential Drugs
Frontiers in Pharmacology, 2019 The proteins of the Ly6 family have a three-finger folding as snake venom α-neurotoxins, targeting nicotinic acetylcholine receptors (nAChRs), and some of them, like mammalian secreted Ly6/uPAR protein (SLURP1) and membrane-attached Ly-6/neurotoxin ...
Elena V. Kryukova +11 more
doaj +1 more source
Active Transport of Peptides Across the Intact Human Tympanic Membrane. [PDF]
, 2018 We previously identified peptides that are actively transported across the intact tympanic membrane (TM) of rats with infected middle ears. To assess the possibility that this transport would also occur across the human TM, we first developed and ...
Alexander, Thomas +9 more
core +1 more source
Functionally important segments in proteins dissected using Gene Ontology and geometric clustering of peptide fragments [PDF]
, 2008 We have developed a geometric clustering algorithm using backbone \varphi,\psi angles to group conformationally similar peptide fragments of any length.
Karuppasamy Manikandan +5 more
core +1 more source
Fibrillisation of hydrophobically modified amyloid peptide fragments in an organic solvent [PDF]
, 2007 The self-assembly of a hydrophobically modified fragment of the amyloid beta(A beta) peptide has been studied in methanol. The peptide FFKLVFF is based on A beta(16-20) extended at the N terminus by two phenylalanine residues.
Castelletto, Valeria +2 more
core +1 more source
PLoS ONE, 2015 Heparanase is an endo-β-glucuronidase that cleaves heparan sulfate side chains from their proteoglycans. Thereby, heparanase liberates highly potent circulating heparan sulfate-fragments (HS-fragments) and triggers the fatal and excessive inflammatory ...
Lukas Martin +8 more
doaj +1 more source
Peptide‐Guided Assembly of Repeat Protein Fragments [PDF]
Angewandte Chemie International Edition, 2018 AbstractHerein, we present the peptide‐guided assembly of complementary fragments of designed armadillo repeat proteins (dArmRPs) to create proteins that bind peptides not only with high affinity but also with good selectivity. We recently demonstrated that complementary N‐ and C‐terminal fragments of dArmRPs form high‐affinity complexes that resemble ...
Michel, Erich +2 more
openaire +2 more sources
Proteomes, 2021 Non-invasive urinary peptide biomarkers are able to detect and predict chronic kidney disease (CKD). Moreover, specific urinary peptides enable discrimination of different CKD etiologies and offer an interesting alternative to invasive kidney biopsy ...
Lorenzo Catanese +6 more
doaj +1 more source
Comparative Analysis of the Major Polypeptides from Liver Gap Junctions and Lens Fiber Junctions [PDF]
, 1982 Gap junctions from rat liver and fiber junctions from bovine lens have similar septilaminar profiles when examined by thin-section electron microscopy and differ only slightly with respect to the packing of intramembrane particles in freeze-fracture ...
Anderson, David J. +3 more
core +2 more sources