Results 61 to 70 of about 2,203,634 (375)
Characterization of Trypsin-Like Protease of Lactobacillus plantarum FNCC 0270
Hayati Journal of Biosciences, 2014 Trypsin is an enzyme that has a unique mechanism of cutting peptide bonds specifically at the carboxyl side of lysine or arginine amino acids, with another amino acid.
Trismilah Margono +3 more
doaj +1 more source
Immunomodulatory and neurotropic activities of synthetic peptides in a model of brain injury in rats
Медицинская иммунология, 2023 Treatment of consequences of traumatic brain injury (TBI) remains one of the current problems of medicine. To increase the effectiveness of treatment of post-traumatic complications, various drugs are recommended, including the peptide with ...
N. B. Serebryanaya +5 more
doaj +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Predicting peptide structures in native proteins from physical simulations of fragments. [PDF]
PLoS Computational Biology, 2009 It has long been proposed that much of the information encoding how a protein folds is contained locally in the peptide chain. Here we present a large-scale simulation study designed to examine the extent to which conformations of peptide fragments in ...
Vincent A Voelz +2 more
doaj +1 more source
Selected Reaction Monitoring (SRM) frente a Western Blot [PDF]
, 2016 We propose the SRM technology as a complementary method to the Western Blot for the detection and quantification of proteins in a sample. The technique Western Blot has its own limitations: i) only a protein-of-choice is detected, ignoring any non ...
Heredia Ponce, Zaira Maria +1 more
core
Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication [PDF]
, 2011 Treslin, a TopBP1-interacting protein, is necessary for deoxyribonucleic acid (DNA) replication in vertebrates. Association between Treslin and TopBP1 requires cyclin-dependent kinase (Cdk) activity in Xenopus laevis egg extracts.
Dunphy, William G. +3 more
core +2 more sources
Photocatalytic Redox Reactions for In‐Source Peptide Fragmentation [PDF]
Chemistry – A European Journal, 2009 AbstractIn‐source oxidation: In‐source photocatalytic redox reactions for inducing peptide fragmentation are achieved on a TiO2‐derived target plate during laser desorption ionization mass spectrometry in the presence of samples and glucose acting as both an electron donor and a hole conductor (see scheme).magnified imageIn‐source photocatalytic redox ...
Hubert H. Girault +6 more
openaire +3 more sources
PLoS ONE, 2010 Background Celiac disease is a T-cell mediated chronic inflammatory disorder of the gut that is induced by dietary exposure to gluten proteins. CD4+ T cells of the intestinal lesion recognize gluten peptides in the context of HLA-DQ2.5 or HLA-DQ8 and the
Siri Dørum +7 more
semanticscholar +1 more source
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
FEBS Letters, EarlyView.The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt +8 more
wiley +1 more source
Peptide and peptide-inspired checkpoint inhibitors: Protein fragments to cancer immunotherapy
Medicine in Drug Discovery, 2020 Immune system regained the attention of oncologists and has entered the mainstream for cancer therapy since the discovery of checkpoint antibodies targeting CTLA4 and PD-1 pathways.
Pottayil G. Sasikumar +1 more
doaj