Results 1 to 10 of about 4,359,325 (366)
Total wash elimination for solid phase peptide synthesis [PDF]
Nature Communications, 2023 We present a process for solid phase peptide synthesis (SPPS) that completely eliminates all solvent intensive washing steps during each amino acid addition cycle.
Jonathan M. Collins +6 more
doaj +2 more sources
Acid-Modulated Peptide Synthesis for Application on Oxide Biosensor Interfaces [PDF]
Nanomaterials, 2023 In this paper we report an acid-modulated strategy for novel peptide microarray production on biosensor interfaces. We initially selected a controlled pore glass (CPG) as a support for solid-phase peptide synthesis (SPPS) to implement a chemistry that ...
Edgar Cristóbal-Lecina +7 more
doaj +2 more sources
Epimerisation in Peptide Synthesis. [PDF]
Molecules, 2023 Epimerisation is basically a chemical conversion that includes the transformation of an epimer into another epimer or its chiral partner. Epimerisation of amino acid is a side reaction that sometimes happens during peptide synthesis. It became the most avoided reaction because the process affects the overall conformation of the molecule, eventually ...
Duengo S +4 more
europepmc +3 more sources
Bio-Protocol, 2012 This protocol describes the synthesis of peptides for affinity testing and bioconjugate with solid phase peptide synthesizer at a small scale.
zheng miao, Zhen Cheng
doaj +2 more sources
Biologic Evaluation of a Heterodimeric HER2-Albumin Targeted Affibody Molecule Produced by Chemo-Enzymatic Peptide Synthesis [PDF]
Pharmaceutics, 2022 Targeted molecular radiation therapy is a promising emerging treatment modality in oncology, and peptide synthesis may shorten the time to reach the clinical stage.
Yongsheng Liu +13 more
doaj +2 more sources
The greening of peptide synthesis
Green Chemistry, 2017 Both couplings and deprotections for solution- and solid-phase peptide synthesis can be carried out in the polar aprotic solvent propylene carbonate.
Stefan B. Lawrenson +2 more
openaire +4 more sources
Liquid-Phase Peptide Synthesis (LPPS): A Third Wave for the Preparation of Peptides.
Chemical Reviews, 2022 Since the last century, peptides have gained wide acceptance as drugs, with almost 100 already in the market and a large number in the pipeline. In this context, peptide synthesis has grown massively as a stringent field for pharmaceuticals around the ...
Anamika Sharma +3 more
semanticscholar +1 more source
Frontiers in Chemistry, 2023 Modern medicine has developed a myriad of therapeutic drugs against a wide range of human diseases leading to increased life expectancy and better quality of life for millions of people.
Ray Yurko +4 more
doaj +1 more source
Antibiotics, 2022 Antimicrobial peptides (AMPs) are considered to be a valuable source for the identification and/or design of promising candidates for the development of antifungal treatments, since they have advantages such as lower tendency to induce resistance, ease ...
Katherine Aguirre-Guataqui +7 more
doaj +1 more source
Scientific Reports, 2022 This manuscript reports an impressive and facile strategy for synthesizing isoxazole derivatives using immobilized Cu (I) in metformin-functionalized β-cyclodextrin as a catalyst.
Mahdieh Tajbakhsh +3 more
doaj +1 more source