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Epimerisation in Peptide Synthesis
Molecules, 2023 Epimerisation is basically a chemical conversion that includes the transformation of an epimer into another epimer or its chiral partner. Epimerisation of amino acid is a side reaction that sometimes happens during peptide synthesis. It became the most avoided reaction because the process affects the overall conformation of the molecule, eventually ...
Suleman Duengo +4 more
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The Lawnmower: an autonomous, protein-based artificial molecular motor [PDF]
Nat Commun 15, 1511 (2024), 2021 Inspired by biology, great progress has been made in creating artificial molecular motors. However, the dream of harnessing proteins - the building blocks selected by Nature - to design autonomous motors has so far remained elusive. Here we report the synthesis and characterization of the Lawnmower, an autonomous, protein-based artificial molecular ...
arxiv +1 more source
Identifying sequential residue patterns in bitter and umami peptides [PDF]
ACS Food Sci. Technol. 2022, 2, 11, 1773--1780, 2022 The primary structures of peptides, originating from food proteins, affect their taste. Connecting primary structure to taste, however, is difficult because the size of the peptide sequence space increases exponentially with increasing peptide length, while experimentally-labeled data on peptides' tastes remain scarce.
arxiv +1 more source
A pathway to peptides in space through the condensation of atomic carbon [PDF]
, 2022 Organic molecules are widely present in the dense interstellar medium, and many have been synthesized in the laboratory on Earth under the conditions typical for an interstellar environment. Until now, however, only relatively small molecules of biological interest have been demonstrated to form experimentally under typical space conditions.
arxiv +1 more source
A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022 Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls +9 more
wiley +1 more source
Introduction to Peptide Synthesis [PDF]
Current Protocols in Protein Science, 2001 AbstractA number of synthetic peptides are significant commercial or pharmaceutical products, ranging from the dipeptide sugar‐substitute aspartame to clinically used hormones, such as oxytocin, adrenocorticotropic hormone, and calcitonin. This unit provides an overview of the field of synthetic peptides and proteins, including their purification.
openaire +6 more sources
pLMFPPred: a novel approach for accurate prediction of functional peptides integrating embedding from pre-trained protein language model and imbalanced learning [PDF]
arXiv, 2023 Functional peptides have the potential to treat a variety of diseases. Their good therapeutic efficacy and low toxicity make them ideal therapeutic agents. Artificial intelligence-based computational strategies can help quickly identify new functional peptides from collections of protein sequences and discover their different functions.Using protein ...
arxiv
TripHLApan: predicting HLA molecules binding peptides based on triple coding matrix and transfer learning [PDF]
arXiv, 2022 Human leukocyte antigen (HLA) is an important molecule family in the field of human immunity, which recognizes foreign threats and triggers immune responses by presenting peptides to T cells. In recent years, the synthesis of tumor vaccines to induce specific immune responses has become the forefront of cancer treatment.
arxiv
Synthesis of Peptide Bioconjugates [PDF]
ChemInform, 2005 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
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Non-equilibrium odds for the emergence of life [PDF]
Phys. Rev. E 99, 052101 (2019), 2017 Large and complex molecules are building blocks for life. We compute probabilities for their formation from an average non-equilibrium model. As the distance from thermodynamic equilibrium is increased in this model, so too are the chances for forming molecules that would be prohibitively rare in thermodynamic equilibrium.
arxiv +1 more source