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Peptide Synthesis

open access: yesBio-Protocol, 2012
This protocol describes the synthesis of peptides for affinity testing and bioconjugate with solid phase peptide synthesizer at a small scale.
zheng miao, Zhen Cheng
doaj   +2 more sources

The greening of peptide synthesis

open access: yesGreen Chemistry, 2017
Both couplings and deprotections for solution- and solid-phase peptide synthesis can be carried out in the polar aprotic solvent propylene carbonate.
Stefan B. Lawrenson   +2 more
openaire   +4 more sources

Liquid-Phase Peptide Synthesis (LPPS): A Third Wave for the Preparation of Peptides.

open access: yesChemical Reviews, 2022
Since the last century, peptides have gained wide acceptance as drugs, with almost 100 already in the market and a large number in the pipeline. In this context, peptide synthesis has grown massively as a stringent field for pharmaceuticals around the ...
Anamika Sharma   +3 more
semanticscholar   +1 more source

Total wash elimination for solid phase peptide synthesis

open access: yesNature Communications, 2023
We present a process for solid phase peptide synthesis (SPPS) that completely eliminates all solvent intensive washing steps during each amino acid addition cycle.
Jonathan M. Collins   +6 more
doaj   +1 more source

Conjugation of amiodarone to a novel cardiomyocyte cell penetrating peptide for potential targeted delivery to the heart

open access: yesFrontiers in Chemistry, 2023
Modern medicine has developed a myriad of therapeutic drugs against a wide range of human diseases leading to increased life expectancy and better quality of life for millions of people.
Ray Yurko   +4 more
doaj   +1 more source

A green protocol for the one-pot synthesis of 3,4-disubstituted isoxazole-5(4H)-ones using modified β-cyclodextrin as a catalyst

open access: yesScientific Reports, 2022
This manuscript reports an impressive and facile strategy for synthesizing isoxazole derivatives using immobilized Cu (I) in metformin-functionalized β-cyclodextrin as a catalyst.
Mahdieh Tajbakhsh   +3 more
doaj   +1 more source

Chimeric Peptides Derived from Bovine Lactoferricin and Buforin II: Antifungal Activity against Reference Strains and Clinical Isolates of Candida spp.

open access: yesAntibiotics, 2022
Antimicrobial peptides (AMPs) are considered to be a valuable source for the identification and/or design of promising candidates for the development of antifungal treatments, since they have advantages such as lower tendency to induce resistance, ease ...
Katherine Aguirre-Guataqui   +7 more
doaj   +1 more source

Introduction to Peptide Synthesis [PDF]

open access: yesCurrent Protocols in Protein Science, 2001
AbstractA number of synthetic peptides are significant commercial or pharmaceutical products, ranging from the dipeptide sugar‐substitute aspartame to clinically used hormones, such as oxytocin, adrenocorticotropic hormone, and calcitonin. This unit provides an overview of the field of synthetic peptides and proteins, including their purification.
Maciej, Stawikowski, Gregg B, Fields
openaire   +8 more sources

Peptides, solid-phase synthesis and characterization: Tailor-made methodologies

open access: yesElectronic Journal of Biotechnology, 2023
Background: Solid-Phase Peptide Synthesis (SPPS) is a mature technique widely used in research and in production. There are different approaches that fulfill the diverse requirements, regarding the number, quantity and quality of peptides.
Fanny Guzmán   +6 more
doaj   +1 more source

Heterologous Rhamnolipid Biosynthesis: Advantages, Challenges, and the Opportunity to Produce Tailor-Made Rhamnolipids

open access: yesFrontiers in Bioengineering and Biotechnology, 2020
The first heterologous expression of genes responsible for the production of rhamnolipids was already implemented in the mid-1990s during the functional identification of the rhlAB operon.
Andreas Wittgens   +4 more
doaj   +1 more source

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