Results 1 to 10 of about 4,995,083 (339)

Game Change from Reagent- to Substrate-Controlled Peptide Synthesis [PDF]

, 2020
An account of the development of Lewis-acid-catalyzed methods for racemization-free peptide synthesis is presented.
Wataru Muramatsu, Tomohiro Hattori, Hisashi Yamamoto   +2 more
semanticscholar   +2 more sources

Total wash elimination for solid phase peptide synthesis [PDF]

Nature Communications, 2023
We present a process for solid phase peptide synthesis (SPPS) that completely eliminates all solvent intensive washing steps during each amino acid addition cycle.
Jonathan M. Collins, Sandeep K. Singh, Travis A. White, Drew J. Cesta, Colin L. Simpson, Levi J. Tubb, Christopher L. Houser   +6 more
doaj   +2 more sources

Process Mass Intensity (PMI): A Holistic Analysis of Current Peptide Manufacturing Processes Informs Sustainability in Peptide Synthesis. [PDF]

J Org Chem
Small molecule therapeutics represent the majority of the FDA-approved drugs. Yet, many attractive targets are poorly tractable by small molecules, generating a need for new therapeutic modalities.
Kekessie I, Wegner K, Martinez I, Kopach ME, White TD, Tom JK, Kenworthy MN, Gallou F, Lopez J, Koenig SG, Payne PR, Eissler S, Arumugam B, Li C, Mukherjee S, Isidro-Llobet A, Ludemann-Hombourger O, Richardson P, Kittelmann J, Sejer Pedersen D, van den Bos LJ.   +20 more
europepmc   +2 more sources

Fundamental Aspects of SPPS and Green Chemical Peptide Synthesis. [PDF]

J Pept Sci
Kent SBH.
europepmc   +3 more sources

Regulation of Host Defense Peptide Synthesis by Polyphenols. [PDF]

Antibiotics (Basel), 2023
Tobin I, Zhang G.
europepmc   +3 more sources

Liquid-Phase Peptide Synthesis (LPPS): A Third Wave for the Preparation of Peptides.

Chemical Reviews, 2022
Since the last century, peptides have gained wide acceptance as drugs, with almost 100 already in the market and a large number in the pipeline. In this context, peptide synthesis has grown massively as a stringent field for pharmaceuticals around the ...
Anamika Sharma, Ashok Kumar, B. G. de la Torre, F. Albericio   +3 more
semanticscholar   +1 more source

Conjugation of amiodarone to a novel cardiomyocyte cell penetrating peptide for potential targeted delivery to the heart

Frontiers in Chemistry, 2023
Modern medicine has developed a myriad of therapeutic drugs against a wide range of human diseases leading to increased life expectancy and better quality of life for millions of people.
Ray Yurko, Kazi Islam, Beth Weber, Guy Salama, Maliha Zahid   +4 more
doaj   +1 more source

A green protocol for the one-pot synthesis of 3,4-disubstituted isoxazole-5(4H)-ones using modified β-cyclodextrin as a catalyst

Scientific Reports, 2022
This manuscript reports an impressive and facile strategy for synthesizing isoxazole derivatives using immobilized Cu (I) in metformin-functionalized β-cyclodextrin as a catalyst.
Mahdieh Tajbakhsh, Mohammad Reza Naimi-Jamal, Saeed Balalaie, Mohadeseh Rezaeian   +3 more
doaj   +1 more source

Chimeric Peptides Derived from Bovine Lactoferricin and Buforin II: Antifungal Activity against Reference Strains and Clinical Isolates of Candida spp.

Antibiotics, 2022
Antimicrobial peptides (AMPs) are considered to be a valuable source for the identification and/or design of promising candidates for the development of antifungal treatments, since they have advantages such as lower tendency to induce resistance, ease ...
Katherine Aguirre-Guataqui, Mateo Márquez-Torres, Héctor Manuel Pineda-Castañeda, Yerly Vargas-Casanova, Andrés Ceballos-Garzon, Zuly Jenny Rivera-Monroy, Javier Eduardo García-Castañeda, Claudia Marcela Parra-Giraldo   +7 more
doaj   +1 more source

Peptides, solid-phase synthesis and characterization: Tailor-made methodologies

Electronic Journal of Biotechnology, 2023
Background: Solid-Phase Peptide Synthesis (SPPS) is a mature technique widely used in research and in production. There are different approaches that fulfill the diverse requirements, regarding the number, quantity and quality of peptides.
Fanny Guzmán, Mónica Aróstica, Tanya Román, Dina Beltrán, Adriana Gauna, Fernando Albericio, Constanza Cárdenas   +6 more
doaj   +1 more source