Results 11 to 20 of about 6,386 (165)
Heterocycles as a Peptidomimetic Scaffold: Solid-Phase Synthesis Strategies
Pharmaceuticals, 2021 Peptidomimetics are a privileged class of pharmacophores that exhibit improved physicochemical and biological properties. Solid-phase synthesis is a powerful tool for gaining rapid access to libraries of molecules from small molecules to biopolymers and ...
Aizhan Abdildinova +2 more
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Triazole-Modified Peptidomimetics: An Opportunity for Drug Discovery and Development
Frontiers in Chemistry, 2021 Peptidomimetics play a fundamental role in drug design due to their preferential properties regarding natural peptides. In particular, compounds possessing nitrogen-containing heterocycles have been intensively studied in recent years.
Agnieszka Staśkiewicz +6 more
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Universal Peptidomimetics [PDF]
Journal of the American Chemical Society, 2010 This paper concerns peptidomimetic scaffolds that can present side chains in conformations resembling those of amino acids in secondary structures without incurring excessive entropic or enthalpic penalties. Compounds of this type are referred to here as minimalist mimics.
Eunhwa, Ko +5 more
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Peptidomimetics as Potential Anti-Virulence Drugs Against Resistant Bacterial Pathogens
Frontiers in Microbiology, 2022 The uncontrollable spread of superbugs calls for new approaches in dealing with microbial-antibiotic resistance. Accordingly, the anti-virulence approach has arisen as an attractive unconventional strategy to face multidrug-resistant pathogens.
Osmel Fleitas Martínez +4 more
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Pharmacological targeting of Sam68 functions in colorectal cancer stem cells
iScience, 2021 Summary: Cancer stem cells (CSCs) are documented to play a key role in tumorigenesis and therapy resistance. Despite significant progress in clinical oncology, CSC reservoirs remain elusive and difficult to eliminate.
Angelique N. Masibag +9 more
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Peptidomimetics Therapeutics for Retinal Disease
Biomolecules, 2021 Ocular disorders originating in the retina can result in a partial or total loss of vision, making drug delivery to the retina of vital importance.
Dylan E. Parsons +6 more
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Biomolecules, 2023 This review provides a fresh overview of non-canonical amino acids and their applications in the design of peptidomimetics. Non-canonical amino acids appear widely distributed in nature and are known to enhance the stability of specific secondary ...
Tarsila G. Castro +4 more
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Computational and Structural Biotechnology Journal, 2023 Heat shock protein 90 (Hsp90) and cell division cycle 37 (Cdc37) work together as a molecular chaperone complex to regulate the activity of a multitude of client protein kinases.
Surya Sukumaran +7 more
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Designing Peptidomimetics [PDF]
Current Topics in Medicinal Chemistry, 2018 The concept of a peptidomimetic was coined about forty years ago. Since then, enormous effort and interest have been devoted to mimic the properties of peptides with small molecules or pseudopeptides. The present report aims to review different approaches described in the past to succeed in this goal.
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Frontiers in Cellular and Infection Microbiology, 2019 Synthetic peptidomimetics may be designed to mimic functions of antimicrobial peptides, including potentiation of antibiotics, yet possessing improved pharmacological properties.
Kristin R. Baker +8 more
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