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The important role of Perforin in protecting against Mycobacterium avium infection in mice [PDF]
Scientific ReportsMycobacterium avium is a drug-resistant bacterium that causes refractory respiratory infection. Perforin protects hosts against viral infection and tumors by inducing apoptosis.
Takato Ikeda +5 more
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Inhibition of Perforin-Mediated Neurotoxicity Attenuates Neurological Deficits After Ischemic Stroke
Frontiers in Cellular Neuroscience, 2021 Perforin-mediated cytotoxicity plays a crucial role in microbial defense, tumor surveillance, and primary autoimmune disorders. However, the contribution of the cytolytic protein perforin to ischemia-induced secondary tissue damage in the brain has not ...
Yuhualei Pan +16 more
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Frontiers in Immunology, 2023 Perforin is a pore-forming protein that plays a crucial role in the immune system by clearing virus-infected or tumor cells. It is released from cytotoxic granules of immune cells and forms pores in targeted lipid membranes to deliver apoptosis-inducing ...
Omar Naneh +4 more
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Covid-19 in a patient with Familial Hemophagocytic Lymphohistiocytosis in children
The Turkish Journal of Pediatrics, 2021 Background. Based on the information obtained so far, COVID- 19 is relatively mild in children. We will present a 6-month-old male patient infected with COVID -19 in April 2020, while receiving HLH 2004 chemotherapy protocol with the diagnosis of ...
V Hülya Üzel, Kamil Yılmaz
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Frontiers in Immunology, 2022 Graphical AbstractCardiac fibrosis developed from fibrotic remodelling due to hypertension leads to heart failure. Immune cells are abundantly accumulated in fibrotic regions, but exact mechanisms how they contributed to cardiac fibrosis are not clear ...
Kurt Brassington +12 more
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Frequent birth-and-death events throughout perforin-1 evolution
BMC Evolutionary Biology, 2020 Background Through its ability to open pores in cell membranes, perforin-1 plays a key role in the immune system. Consistent with this role, the gene encoding perforin shows hallmarks of complex evolutionary events, including amplification and ...
Miguel Araujo-Voces, Víctor Quesada
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Perforins Expression by Cutaneous Gamma Delta T Cells
Frontiers in Immunology, 2020 Gamma delta (GD) T cells are an unconventional T cell type present in both the epidermis and the dermis of human skin. They are critical to regulating skin inflammation, wound healing, and anti-microbial defense.
Katelyn O'Neill +3 more
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CTLs: Killers of intracellular bacteria
Frontiers in Cellular and Infection Microbiology, 2022 Many microbial pathogens have evolved a range of capabilities to evade host immune defense mechanisms and to survive and multiply in host cells. The presence of host intracellular bacteria makes it difficult for specific antibodies to function. After the
Li Tian +8 more
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Acta Veterinaria, 2023 Some cats live at home with their owners while others live unattended on the streets or in shelters. One might expect that the owned cats would be better prepared for diseases with vaccinations, and good care and feeding conditions whereas the stray cats
Temizkan Mehmet Cevat +4 more
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Endometrial Cancer Suppresses CD8+ T Cell-Mediated Cytotoxicity in Postmenopausal Women
Frontiers in Immunology, 2021 Endometrial cancer is the most common gynecological cancer. To investigate how it suppresses host immune function, we isolated CD8+ T cells from endometrial endometroid carcinomas and adjacent non-cancerous endometrium and determined if the tumor ...
Mickey V. Patel +5 more
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