Results 21 to 30 of about 49,701 (247)

Perforin-deficient CAR T cells recapitulate late-onset inflammatory toxicities observed in patients.

Journal of Clinical Investigation, 2020
Late-onset inflammatory toxicities resembling hemophagocytic lymphohistiocytosis (HLH) or macrophage activation syndrome (MAS) occur after chimeric antigen receptor T cell (CAR T cell) infusion and represent a therapeutic challenge. Given the established
Kazusa Ishii, M. Pouzolles, Christopher D. Chien, R. Erwin-Cohen, M. Kohler, Haiying Qin, Haiyan Lei, Skyler Kuhn, A. Ombrello, Alina Dulau-Florea, M. Eckhaus, Haneen Shalabi, B. Yates, D. Lichtenstein, V. Zimmermann, T. Kondo, J. Shern, H. Young, N. Taylor, N. Shah, T. Fry   +20 more
semanticscholar   +1 more source

All About (NK Cell-Mediated) Death in Two Acts and an Unexpected Encore: Initiation, Execution and Activation of Adaptive Immunity

Frontiers in Immunology, 2022
NK cells are key mediators of immune cell-mediated cytotoxicity toward infected and transformed cells, being one of the main executors of cell death in the immune system.
Ariel Ramírez-Labrada, Ariel Ramírez-Labrada, Ariel Ramírez-Labrada, Cecilia Pesini, Cecilia Pesini, Llipsy Santiago, Llipsy Santiago, Sandra Hidalgo, Sandra Hidalgo, Adanays Calvo-Pérez, Adanays Calvo-Pérez, Carmen Oñate, Carmen Oñate, Alejandro Andrés-Tovar, Marcela Garzón-Tituaña, Marcela Garzón-Tituaña, Iratxe Uranga-Murillo, Iratxe Uranga-Murillo, Maykel A. Arias, Maykel A. Arias, Eva M. Galvez, Eva M. Galvez, Julián Pardo, Julián Pardo, Julián Pardo   +24 more
doaj   +1 more source

Recent Advances in Molecular Mechanisms of the NKG2D Pathway in Hepatocellular Carcinoma

Biomolecules, 2020
Hepatocellular carcinoma is a common malignant tumor with high mortality. Its malignant proliferation, invasion, and metastasis are closely related to the cellular immune function of the patients.
Jian Wang, Cun-Di Li, Lin Sun
doaj   +1 more source

Apicomplexan perforin-like proteins [PDF]

Communicative & Integrative Biology, 2010
Numerous perforin-like proteins are encoded in the genomes of apicomplexan parasites, where they are expressed in various life-cycle stages and play critical roles in pathogenesis and lifecycle progression. These ApiPLPs are characterized by the presence of a MACPF domain, responsible for pore-formation in target membranes in a number of systems ...
Björn F C, Kafsack, Vern B, Carruthers
openaire   +2 more sources

Detection of Perforin in suspension of leukemia lymphocyte culture

مجلة مركز بحوث التقنيات الاحيائية, 2014
This work aimed to study the concentrations and hemolytic assay of perforin in serum and culture suspension of lymphocyte for acute lymphocyte leukemia ALL; chronic lymphocyte leukemia CLL, and control. To achieve this goal, blood samples were collected
Najwa Sh. Ahmed, Amal G.S. Fayyad, Wan Mohter Yusoff, Subhi Jawad Hamza, Abdul Hussen Al-Faisal, Adeeb A. AL-Shami   +5 more
doaj   +1 more source

Perforin enhances the granulysin-induced lysis of Listeria innocua in human dendritic cells

BMC Immunology, 2007
Background Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells play an essential role in the host defence against intracellular pathogens such as Listeria, and Mycobacteria.
Wagner Carsten A, Dumrese Claudia, Sundstrom Hanna, Velic Ana, Latinovic-Golic Sonja, Walch Michael, Groscurth Peter, Ziegler Urs   +7 more
doaj   +1 more source

Breaching the Bacterial Envelope: The Pivotal Role of Perforin-2 (MPEG1) Within Phagocytes

Frontiers in Immunology, 2021
The membrane attack complex (MAC) of the complement system and Perforin-1 are well characterized innate immune effectors. MAC is composed of C9 and other complement proteins that target the envelope of gram-negative bacteria.
Leidy C. Merselis, Zachary P. Rivas, George P. Munson   +2 more
doaj   +1 more source

Gene therapy of prostate cancer using liposomes containing perforin expression vector driven by the promoter of prostate-specific antigen gene

Scientific Reports, 2022
Perforin secreted from cytotoxic lymphocytes plays a critical role in cancer immunosurveillance. The aim of this study was to investigate the therapeutic potential of liposomes containing perforin expression vector driven by the promotor of prostate ...
Kosuke Mizutani, Kyojiro Kawakami, Yasunori Fujita, Taku Kato, Manabu Takai, Daiki Kato, Koji Iinuma, Takuya Koie, Masafumi Ito   +8 more
doaj   +1 more source

Tim-3 suppresses the killing effect of Vγ9Vδ2 T cells on colon cancer cells by reducing perforin and granzyme B expression.

Experimental Cell Research, 2019
Gamma delta (γδ) T cell-based tumor immunotherapy has been one of the most promising cancer immunotherapeutic strategies. However, the key regulators of the Vγ9Vδ2 T cell-mediated antitumor response remain unclear.
Xiaomi Li, Huimin Lu, Yan-zheng Gu, Xueguang Zhang, Guangbo Zhang, Tongguo Shi, Weichang Chen   +6 more
semanticscholar   +1 more source

Severely ill and high-risk COVID-19 patients exhibit increased peripheral circulation of CD62L+ and perforin+ T cells

Frontiers in Immunology, 2023
IntroductionThe emergence of SARS-CoV-2, which causes COVID-19, has led to over 400 million reported cases worldwide. COVID-19 disease ranges from asymptomatic infection to severe disease and may be impacted by individual immune differences.MethodsWe ...
Kelsey E. Lesteberg, Kelsey E. Lesteberg, Paula Araya, Katherine A. Waugh, Katherine A. Waugh, Lakshmi Chauhan, Joaquin M. Espinosa, Joaquin M. Espinosa, J. David Beckham, J. David Beckham, J. David Beckham, J. David Beckham   +11 more
doaj   +1 more source