Results 121 to 130 of about 13,212 (232)

The phosphorylation of serine 492 of perilipin A facilitates ATGL-mediated lipolysis by CGI-58 independent mechanisms

, 2014
Perilipin A is a lipid droplet-associated protein that controls triacylglycerol storage and hydrolysis in adipocytes. Lipolysis of triacylglycerols by adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) is enabled by the phosphorylation
Hernandez, Mayda, 1989-
core   +1 more source

The perilipin-2 (adipophilin) coat of cytosolic lipid droplets is regulated by an Arf1-dependent mechanism in HC11 mouse mammary epithelial cells

, 2016
The cytosolic lipid droplets (cLDs) store excess intracellular lipids, and perilipin-2 is believed to protect cLDs from degradation. Here, we investigated the role of the small G-protein Arf1 and the proteasome in the fates of perilipin-2 and cLDs.
Chanat, Eric, Hue-Beauvais, Catherine, Pauloin, Alain, Adenot, Pierre   +3 more
core   +1 more source

Perilipin1 inhibits Nosema bombycis proliferation by promoting Domeless- and Hop-mediated JAK-STAT pathway activation in Bombyx mori

Microbiology Spectrum
Lipid droplets (LDs) are dynamic organelles that participate in the regulation of lipid metabolism and cellular homeostasis inside of cells. LD-associated proteins, also known as perilipins (PLINs), are a family of proteins found on the surface of LDs ...
Yaping Su, Qingsheng Qu, Junling Li, Zhenghao Han, Yujia Fang, Billong Laura Flavorta, Zhenwei Jia, Qiong Yu, Yiling Zhang, Ping Qian, Xudong Tang   +10 more
doaj   +1 more source

Lipolysis and lipases in white adipose tissue – An update

Archives of Endocrinology and Metabolism
Lipolysis is defined as the sequential hydrolysis of triacylglycerol (TAG) stored in cell lipid droplets. For many years, it was believed that hormone-sensitive lipase (HSL) and monoacylglycerol lipase (MGL) were the main enzymes catalyzing lipolysis in ...
Andressa Bolsoni-Lopes, Maria Isabel C. Alonso-Vale   +1 more
doaj   +1 more source

Regulation of adipocyte lipolysis by degradation of the perilipin protein: nelfinavir enhances lysosome-mediated perilipin proteolysis.

The Journal of biological chemistry, 2007
A decrease in the lipid droplet-associated protein perilipin may constitute a mechanism for enhanced adipocyte lipolysis under nonstimulated (basal) conditions, and increased basal lipolysis has been linked to whole body metabolic dysregulation. Here we investigated whether the lipolytic actions of the human immunodeficiency virus protease inhibitor ...
Julia, Kovsan, Ronit, Ben-Romano, Sandra C, Souza, Andrew S, Greenberg, Assaf, Rudich   +4 more
openaire   +1 more source

Evidence of a Perilipin 5 Splice Variant [PDF]

, 2017
Alternative splicing occurs throughout the human genome, leading to multiple proteins from a single gene. The resulting proteins can be nearly identical or vastly different in how they function.
Ranzau, Brodie
core  

The pathway of LD formation in adipose cells featured by perilipin and vimentin localization.

, 2014
Delineated stages of the endogenous LD-formation are schematically presented with additional brief descriptions of individual steps and involved proteins and organelles, respectively.
Yvette Dörflinger (173737), Hans Heid (413935), Heiderose Schumacher (413939), Stefanie Winter (413938), Caecilia Kuhn (529370), Ralf Zimbelmann (413937), Steffen Rickelt (413936), Werner W. Franke (529371)   +7 more
core   +1 more source

Inhibit of Transport of Perilipin 5

Perilipin 5 is involved in insulin sensitivity and lipid breakdown which if not regulated properly causes many metabolic diseases. Obesity, type II diabetes, hepatic steatosis, and atherosclerosis are caused by excess neutral lipid storage (Zehmer, J. K.,
Storrer, Erin
core  

Human skeletal muscle perilipin 2 and 3 expression varies with insulin sensitivity

, 2013
Background: Impaired insulin sensitivity may partly arise from a dysregulated lipid metabolism in human skeletal muscle. This study investigates the expression levels of perilipin 2, 3, and 5, and four key lipases in human skeletal muscle from the ...
Prats Gavalda, Clara, Ploug, Thorkil, Vigelsø Hansen, Andreas, Dela, Flemming, Helge, Jørn Wulff   +4 more
core   +1 more source

The phospholipid monolayer associated with perilipin-enriched lipid droplets is a highly organized rigid membrane structure

, 2011
The significance of lipid droplets (LD) in lipid metabolism, cell signaling, and membrane trafficking is increasingly recognized, yet the role of the LD phospholipid monolayer in LD protein targeting and function remains unknown. To begin to address this
Kenneth C. Moon, Barbara P. Atshaves, Avery L. McIntosh, Stephen M. Storey, Subramanian Senthivinayagam   +4 more
core   +1 more source