Results 21 to 30 of about 1,976 (189)

Direct Proteomic Mapping of Cysteine Persulfidation [PDF]

Antioxidants & Redox Signaling, 2020
Aims: Cysteine persulfidation (also called sulfhydration or sulfuration) has emerged as a potential redox mechanism to regulate protein functions and diverse biological processes in hydrogen sulfide (H2S) signaling. Due to its intrinsically unstable nature, working with this modification has proven to be challenging.
Ling, Fu, Keke, Liu, Jingyang, He, Caiping, Tian, Xiaobo, Yu, Jing, Yang   +5 more
openaire   +2 more sources

Therapeutic Efficacy of the Supersulfide Donor NAC-S2 in Influenza Virus Pneumonia via Suppression of Excessive Inflammatory Responses. [PDF]

Microbiol Immunol
ABSTRACT Influenza pneumonia is characterized by excessive inflammatory responses that contribute to severe lung injury and mortality. Supersulfides, endogenously produced cysteine‐derived persulfides and polysulfides, exert potent antioxidant, anti‐ferroptotic, and anti‐inflammatory activities; however, their therapeutic potential after disease onset ...
Hossen F, Kouwaki T, Fujiwara Y, Tsutsuki H, Zhang T, Guo C, Rahman A, Komohara Y, Oshiumi H, Sawa T.   +9 more
europepmc   +2 more sources

Cysteine trisulfide oxidizes protein thiols and induces electrophilic stress in human cells

Redox Biology, 2021
The cellular effects of hydrogen sulfide (H2S) signaling may be partially mediated by the formation of alkyl persulfides from thiols, such as glutathione and protein cysteine residues.
Christopher H. Switzer, Sebastian Guttzeit, Thomas R. Eykyn, Philip Eaton   +3 more
doaj   +1 more source

The role of sulfur compounds in chronic obstructive pulmonary disease

Frontiers in Molecular Biosciences, 2022
Chronic obstructive pulmonary disease (COPD) is a common respiratory disease that brings about great social and economic burden, with oxidative stress and inflammation affecting the whole disease progress. Sulfur compounds such as hydrogen sulfide (H2S),
Simin Jiang, Yahong Chen
doaj   +1 more source

Persulfide Biosynthesis Conserved Evolutionarily in All Organisms. [PDF]

Antioxid Redox Signal, 2023
Significance: Persulfides/polysulfides are sulfur-catenated molecular species (i.e., R-Sn-R', n > 2; R-Sn-H, n > 1, with R = cysteine, glutathione, and proteins), such as cysteine persulfide (CysSSH). These species are abundantly formed as endogenous metabolites in mammalian and human cells and tissues.
Ogata S, Matsunaga T, Jung M, Barayeu U, Morita M, Akaike T.   +5 more
europepmc   +3 more sources

Generation of Rat Monoclonal Antibody to Detect Hydrogen Sulfide and Polysulfides in Biological Samples

Antioxidants, 2020
Hydrogen sulfide (H2S) is endogenously produced by enzymes and via reactive persulfide/polysulfide degradation; it participates in a variety of biological processes under physiological and pathological conditions. H2S levels in biological fluids, such as
Shingo Kasamatsu, Yuki Kakihana, Taisei Koga, Hisashi Yoshioka, Hideshi Ihara   +4 more
doaj   +1 more source

Contribution of NRF2 to sulfur metabolism and mitochondrial activity

Redox Biology, 2023
NF-E2-related factor 2 (NRF2) plays a crucial role in the maintenance of cellular homeostasis by regulating various enzymes and proteins that are involved in the redox reactions utilizing sulfur.
Md Morshedul Alam, Akihiro Kishino, Eunkyu Sung, Hiroki Sekine, Takaaki Abe, Shohei Murakami, Takaaki Akaike, Hozumi Motohashi   +7 more
doaj   +1 more source

Protein Persulfidation in Plants: Function and Mechanism [PDF]

Antioxidants, 2021
As an endogenous gaseous transmitter, the function of hydrogen sulfide (H2S) has been extensively studied in plants. Once synthesized, H2S may be involved in almost all life processes of plants. Among them, a key route for H2S bioactivity occurs via protein persulfidation, in which process oxidizes cysteine thiol (R-SH) groups into persulfide (R-SSH ...
Peng Wang, Hua Fang, Rong Gao, Weibiao Liao   +3 more
openaire   +3 more sources

Toxic Tear Gas 2-Chloroacetophenone (CN) Forms Adducts With Endogenous Plasma Thiols In Vitro Valuable as Biomarkers of Exposure. [PDF]

Drug Test Anal
Incubation of human plasma with the tear gas 2‐chloroacetophenone (CN) led to the formation of acetophenone (AcPhen)‐adducts with the small plasma thiols glutathione, homocysteine, and cysteine persulfide. The AcPhen‐adducts were either bound to an organic thiol‐group or to an organic persulfide. The adducts were detected with a mass spectrometry‐based
Sieber PH, Steinritz D, Worek F, John H.
europepmc   +2 more sources

Enzymatic Regulation and Biological Functions of Reactive Cysteine Persulfides and Polysulfides

Biomolecules, 2020
Cysteine persulfide (CysSSH) and cysteine polysulfides (CysSSnH, n > 1) are cysteine derivatives that have sulfane sulfur atoms bound to cysteine thiol. Advances in analytical methods that detect and quantify persulfides and polysulfides have shown that ...
Tomohiro Sawa, Hozumi Motohashi, Hideshi Ihara, Takaaki Akaike   +3 more
doaj   +1 more source