Results 61 to 70 of about 1,976 (189)

Cysteine persulfides and polysulfides produced by exchange reactions with H2S protect SH-SY5Y cells from methylglyoxal-induced toxicity through Nrf2 activation

Redox Biology, 2017
Many physiological functions of hydrogen sulfide (H2S) have been reported in mammalian cells over the last 20 years. These physiological effects have been ascertained through in vitro treatment of cells with Na2S or NaHS, both of which are precursors of ...
Shin Koike, Shoichi Nishimoto, Yuki Ogasawara   +2 more
doaj   +1 more source

Influence of association state and DNA binding on the O2-reactivity of [4Fe-4S] fumarate and nitrate reduction (FNR) regulator [PDF]

, 2014
The fumarate and nitrate reduction (FNR) regulator is the master switch for the transition between anaerobic and aerobic respiration in Escherichia coli.
Andrew J. Thomson, Bates, Beinert, Crack, Crack, Crack, Crack, Crack, Edwards, Green, Green, Green, Green, Guest, Guest, Jason C. Crack, Jeffrey Green, Jervis, Jordan, Khoroshilova, Khoroshilova, Kiley, Kiley, Kuzmic, Lazazzera, Lazazzera, Melanie R. Stapleton, Meng, Miller, Moore, Moore, Nick E. Le Brun, Reents, Scott, Sharrocks, Sharrocks, Sutton, Unden, Unden, Vogel, Zhang, Ziegelhoffer   +41 more
core   +1 more source

TtcA a new tRNA-thioltransferase with an Fe-S cluster [PDF]

, 2014
International audienceTtcA catalyzes the post-transcriptional thiolation of cytosine 32 in some tRNAs. The enzyme from Es-cherichia coli was homologously overexpressed in E. coli.
Atta, Mohamed, Bouvier, Denis, Clémancey, Martin, Fontecave, Marc, Labessan, Natty, Latour, Jean-Marc, Ravanat, Jean-Luc   +6 more
core   +4 more sources

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems [PDF]

Science Advances, 2016
Protein Persulfide Detection Protocol reveals vital roles for thioredoxin and glutathione systems in maintaining sulfane sulfur homeostasis in cells and in vivo.
Éva Dóka, Irina Pader, Adrienn Bíró, Katarina Johansson, Qing Cheng, Krisztina Ballagó, Justin R. Prigge, Daniel Pastor-Flores, Tobias P. Dick, Edward E. Schmidt, Elias S. J. Arnér, Péter Nagy   +11 more
openaire   +3 more sources

Supersulfide donors and their therapeutic targets in inflammatory diseases

Frontiers in Immunology
Inflammation is one defense mechanism of the body that has multiple origins, ranging from physical agents to infectious agents including viruses and bacteria.
Tianli Zhang, Yuexuan Pan, Tomohiro Sawa, Takaaki Akaike, Takaaki Akaike, Tetsuro Matsunaga, Tetsuro Matsunaga   +6 more
doaj   +1 more source

Redox Modulation at Work: Natural Phytoprotective Polysulfanes From Alliums Based on Redox-Active Sulfur [PDF]

, 2018
Purpose of review: This article provides a brief overview of natural phytoprotective products of allium with a special focus on the therapeutic potential of diallyl polysulfanes from garlic, their molecular targets and their fate in the living organisms.
A Anwar, A Anwar, A Anwar, A Arunkumar, A Das, A Muller, AA Powolny, BA Iwalokun, BC Lee, C Chen, C Jacob, C Oosthuizen, CD Fisher, CJ Cavallito, CS Yang, D Liang, D Wallock-Richards, D Xiao, DM Davenport, DR Allah, E Germain, EA O'Gara, EA O'Gara, F Aala, F Zhang, G Ferrer-Sueta, G Filomeni, G Li, G Li, GA Benavides, GC Wallace, H Fujisawa, H Jurkowska, H Nakagawa, H Nian, H Tsuchiya, HC Wang, HT Hassan, I Gull, I Gull, J Antosiewicz, J Taucher, Jana Reiter, JM Bradley, K Chandra-Kuntal, KC Lai, KL Liu, L Cellini, L Masip, L Yi, LD Lawson, M Abouelfetouh, M Iciek, M Zardast, Małgorzata Iciek, MB Iciek, MC Gruhlke, Michael Puccinelli, MM Fani, MW Ha, N Druesne, NEB Saidu, NEB Saidu, P Gong, P Mikaili, P Rattanachaikunsopon, Qing Liu, RR Cutler, S Ankri, S Kim, S Shetty, SD Stan, SK Saha, T Hosono, T Schneider, T Seki, Toyohiko Ariga, U Münchberg, VA Kiesel, WR Li, X-y Lei, XY Jiang, Y Liu, Y Shadkchan, YA Kim, YR Cai, Z Shigemi, Z Wang, ZM Ross   +88 more
core   +1 more source

Clonal Stabilization Reveals a DAO/3MST‐Expressing MDCK Subpopulation With Robust d‐Cysteine‐Mediated H2S Production

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
A subpopulation of MDCK (NBL‐2) cells, an epithelial cell line derived from the normal kidney, expresses DAO and 3MST. The DAO/3MST‐expressing cells are progressively eliminated during passaging; however, clonal isolation enables the establishment of sublines that maintain stable H2S production. Clonal cells co‐expressing DAO and 3MST therefore provide
Akari Miyamoto, Haruna Ueno, Hideo Kimura, Tadashi Nakagawa, Norihiro Shibuya   +4 more
wiley   +1 more source

The Therapeutic Potential of Supersulfides in Oxidative Stress-Related Diseases

Biomolecules
Oxidation-reduction (redox) reactions are fundamental to sustaining life, with reactive oxygen and nitrogen species playing pivotal roles in cellular signaling and homeostasis. However, excessive oxidative stress disrupts redox balance, contributing to a
Yuexuan Pan, Tetsuro Matsunaga, Tianli Zhang, Takaaki Akaike   +3 more
doaj   +1 more source

Cytoplasmic sulfurtransferases in the purple sulfur bacterium Allochromatium vinosum: evidence for sulfur transfer from DsrEFH to DsrC. [PDF]

PLoS ONE, 2012
While the importance of sulfur transfer reactions is well established for a number of biosynthetic pathways, evidence has only started to emerge that sulfurtransferases may also be major players in sulfur-based microbial energy metabolism.
Yvonne Stockdreher, Sofia S Venceslau, Michaele Josten, Hans-Georg Sahl, Inês A C Pereira, Christiane Dahl   +5 more
doaj   +1 more source