Rare isolation of human-tropic recombinant porcine endogenous retroviruses PERV-A/C from Göttingen minipigs [PDF]
Virology Journal, 2022 Background Porcine endogenous retroviruses (PERVs) can infect human cells and pose a risk for xenotransplantation when pig cells, tissues or organs are transplanted to human recipients.
Sabrina Halecker +9 more
doaj +5 more sources
Copy Number and Prevalence of Porcine Endogenous Retroviruses (PERVs) in German Wild Boars [PDF]
Viruses, 2020 Porcine endogenous retroviruses (PERVs) are integrated in the genome of pigs and are transmitted like cellular genes from parents to the offspring. Whereas PERV-A and PERV-B are present in all pigs, PERV-C was found to be in many, but not all pigs.
Luise Krüger +5 more
doaj +4 more sources
Genomic presence of recombinant porcine endogenous retrovirus in transmitting miniature swine [PDF]
Virology Journal, 2006 The replication of porcine endogenous retrovirus (PERV) in human cell lines suggests a potential infectious risk in xenotransplantation. PERV isolated from human cells following cocultivation with porcine peripheral blood mononuclear cells is a ...
Wilkinson Robert +2 more
doaj +2 more sources
Preliminary PCR-Based Screening Indicates a Higher Incidence of Porcine Endogenous Retrovirus Subtype C (PERV-C) in Feral Versus Domestic Swine [PDF]
Transactions of the Kansas Academy of Science, 2019 Xenotransplantation is considered a potential alternative to allotransplantation to relieve the current shortage of human organs. Due to their similar size and physiology, the organs of pigs are of particular interest for this purpose. Endogenous retroviruses are a result of integration of retroviral genomes into the genome of infected germ cells as ...
Acharya, Rashmi +3 more
openaire +3 more sources
Porcine Endogenous Retroviruses and Xenotransplantation, 2021 [PDF]
Viruses, 2021 Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs, and some of them are able to infect human cells. Therefore, PERVs pose a risk for xenotransplantation, the transplantation of pig cells, tissues, or organ to humans in ...
Joachim Denner
doaj +3 more sources
Virological Characterization of Pigs with Erythema Multiforme [PDF]
Microorganisms, 2022 Erythema multiforme in pigs is an acute, self-limiting disease characterized by red skin areas and often associated with anorexia, fever and respiratory problems. The cause of the disease remains unknown.
Sabrina Halecker +5 more
doaj +3 more sources
Screening for Viruses in Indigenous Greek Black Pigs [PDF]
MicroorganismsThe successful advancement of xenotransplantation has led to the development of highly sensitive detection systems for the screening of potentially zoonotic viruses in donor pigs and preventing their transmission to the recipient.
Hina Jhelum +5 more
doaj +3 more sources
Klonierung und Charakterisierung eines ecotropen porzinen endogenen Retrovirus der Klasse C (PERV-C) [PDF]
, 2007 Durch die vertikale Vererbung von endogenen Retroviren, deren Fähigkeit humane Zellen in vitro zu infizieren und ihrer Rekombinationsfähigkeit besteht ein Risikopotential bei der Verwendung porziner Gewebe bzw. Organe im Rahmen der XTx, weshalb ein Screening auf PERV im Genom von Spendertieren und eine immunologische Kontrolle von ...
Preuß, Thomas
openaire +2 more sources
A: Retrotranspositionspotential endogener und exogener Retroviren und B: Durchmusterung verschiedener transgener Schweine auf Anwesenheit replikationskompetenter PERV-A und PERV-B sowie ekotroper PERV-C [PDF]
, 2008 Bei endogenen Retroviren handelt es sich um feste Bestandteile des Genoms. Im Fall von PERV (porzine endogene Retroviren) existieren zusätzlich infektiöse, xenotrope Vertreter. Aufgrund dieser Tatsache ist es notwendig, diese replikationskompetenten Proviren aus dem Genom potentieller Donortiere für die Xenotransplantation zu entfernen.
Jungmann, Andreas
openaire +3 more sources
Isolation of an Ecotropic Porcine Endogenous Retrovirus PERV-C from a Yucatan SLAD/D Inbred Miniature Swine. [PDF]
J Virol, 2023 Yucatan SLA D/D haplotype miniature swine are candidates as organ donors for xenotransplantation. A full-length replication-competent PERV-C provirus was characterized. The provirus was chromosomally mapped in the pig genome. In vitro , the virus showed increased infectivity compared to other
Rodrigues Costa M +5 more
europepmc +3 more sources