Rare isolation of human-tropic recombinant porcine endogenous retroviruses PERV-A/C from Göttingen minipigs [PDF]
Virology Journal, 2022 Background Porcine endogenous retroviruses (PERVs) can infect human cells and pose a risk for xenotransplantation when pig cells, tissues or organs are transplanted to human recipients.
Sabrina Halecker +9 more
doaj +2 more sources
Біологія тварин, 2021 The article presents the analysis of the PERV retrovirus subtypes A and C frequency in populations of Ukrainian and foreign breed pigs. Different frequencies of the PERV A/C genome presence in animals of the studied breeds were established.
T. M. Ryk
doaj +2 more sources
Cell Transplantation, 2008 Previously a strategy for monitoring of pigs intended for cell transplantation was developed and successfully applied to several representative herds in New Zealand.
O. Garkavenko +10 more
doaj +2 more sources
Characterization of Insertional Variation of Porcine Endogenous Retroviruses in Six Different Pig Breeds [PDF]
Asian-Australasian Journal of Animal Sciences, 2012 Pigs may need to be exploited as xenotransplantation donors due to the shortage of human organs, tissues and cells. Porcine endogenous retroviruses (PERVs) are a significant obstacle to xenotransplantation because they can infect human cells in vitro and
W. Y. Jung +7 more
doaj +1 more source
Reframing Technology and Ethics in Corneal Xenotransplantation: A Scoping Review of Standards and Safety in Ophthalmology [PDF]
Health Care SciBringing attention to the moral dilemmas raised by xenotransplantation and the continuous creation of standardized frameworks for donor technology and biosafety risk management, with a focus on striking a balance between patient safety, medical innovation, and ethical obligation.
Saha S, Dutta M, Bosu A.
europepmc +2 more sources
Scientific Reports, 2020 Several xenogenic cell-based therapeutic products are currently under development around the world for the treatment of human diseases. Porcine islet cell products for treating human diabetes are a typical example.
Ken Kono +5 more
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Copy Number and Prevalence of Porcine Endogenous Retroviruses (PERVs) in German Wild Boars
Viruses, 2020 Porcine endogenous retroviruses (PERVs) are integrated in the genome of pigs and are transmitted like cellular genes from parents to the offspring. Whereas PERV-A and PERV-B are present in all pigs, PERV-C was found to be in many, but not all pigs.
Luise Krüger +5 more
doaj +1 more source
First virological and pathological study of Göttingen Minipigs with Dippity Pig Syndrome (DPS).
PLoS ONE, 2023 Dippity Pig Syndrome (DPS) is a well-known but rare complex of clinical signs affecting minipigs, which has not been thoroughly investigated yet. Clinically affected animals show acute appearance of red, exudating lesions across the spine.
Hina Jhelum +13 more
doaj +1 more source
Suboptimal porcine endogenous retrovirus infection in non-human primate cells: implication for preclinical xenotransplantation. [PDF]
PLoS ONE, 2010 BACKGROUND: Porcine endogenous retrovirus (PERV) poses a potential risk of zoonotic infection in xenotransplantation. Preclinical transplantation trials using non-human primates (NHP) as recipients of porcine xenografts present the opportunity to assess ...
Giada Mattiuzzo, Yasuhiro Takeuchi
doaj +1 more source
Differential resistance to cell entry by porcine endogenous retrovirus subgroup A in rodent species [PDF]
, 2007 Background: The risk of zoonotic infection by porcine endogenous retroviruses (PERV) has been highlighted in the context of pig-to-human xenotransplantation. The use of receptors for cell entry often determines the host range of retroviruses.
Matouskova, M +8 more
core +1 more source