Results 31 to 40 of about 18,673,205 (171)

Impact of various detergent-based immersion and perfusion decellularization strategies on the novel caprine pancreas derived extracellular matrix scaffold

Frontiers in Bioengineering and Biotechnology, 2023
Limited availability of the organs donors has facilitated the establishment of xenogeneic organ sources for transplantation. Numerous studies have decellularized several organs and assessed their implantability in order to provide such organs.
Garima Singh, Sanghamitra Satpathi, Bora Venu Gopala Reddy, Manish Kumar Singh, Samchita Sarangi, Prativa Kumari Behera, Bismita Nayak   +6 more
doaj   +1 more source

Absence of infection in pigs inoculated with high-titre recombinant PERV-A/C [PDF]

, 2011
Porcine endogenous retroviruses (PERVs) represent a risk for xenotransplantation using pig cells or organs since they are integrated in the genome of all pigs and infect human cells in vitro.
R. Plesker, A. Geissler, Kaulitz, Danny, Tönjes, Ralf R., R. R. Tönjes, Plesker, Roland, Geissler, Anne, J. Denner, D. Mihica, D. Kaulitz, Denner, Joachim, Mihica, Debora   +11 more
core   +1 more source

PERV-positive organs in infected mice.

, 2016
PERV-positive organs in infected mice.
Young bong Kim (3342038), Jae Myung Yang (3342041), Jiwon Choi (740792), Sehyun Kim (2697172), Yu-Kyoung Oh (297262), Yong-Dae Gwon (486539), Yeondong Cho (554917), Nayoung Kim (67514)   +7 more
core   +1 more source

PERV und Xenotransplantation: Impfstoffe, RNAi und genotypische Selektion [PDF]

, 2011
Die porzinen endogenen Retroviren (PERVs) stellen für die Xenotransplantation derzeit ein schwer einzuschätzendes Risiko dar. Sie besitzen die Fähigkeit, in vitro humane Zelllinien zu infizieren und sich an diese zu adaptieren.
Kaulitz, Danny
core   +1 more source

The infectivity and host range of the ecotropic porcine endogenous retrovirus, PERV-C, is modulated by residues in the C-terminal region of its surface envelope protein [PDF]

, 2006
Endogenous retroviral genetic material serves as a reservoir for the generation of retroviral pathogens by recombination between activated endogenous or exogenous infectious agents.
Wilson, Carolyn A., Gemeniano, Malou, Eiden, Maribeth V., Mpanju, Onesmo, Salomon, Daniel R.   +4 more
core   +1 more source

Establishment of a donor pig for xenotransplantation clinical trials based on the principle of Changsha Communiqué

Health Care Science, 2023
Background Xenotransplantation is a potential way to reduce the shortage of the needed organ grafts for the end‐stage disease. Immune rejection, physiological incompatibility and bio‐safety are the most critical issues.
Xiaoqian Ma, Sang Li, Jia Wang, Chang Xu, Wei Wang   +4 more
doaj   +1 more source

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Discovery and Engineering of a Rat Endogenous Retrovirus Reverse Transcriptase for Efficient Prime Editing. [PDF]

Adv Sci (Weinh)
We screened 558 reverse transcriptases and engineered an optimized rat endogenous retrovirus‐derived variant, enRERV‐RT, via structure‐guided engineering and deep mutational scanning. This enhanced prime editor, based on the engineered RT, outperforms conventional M‐MLV‐RT systems across plant and animal cells, particularly at hard‐to‐edit loci ...
Ma L, Yao P, Wu S, Shi Y, Qin L, Li B, Zhu J, Huang M, Zhu Y, Song Y, Pang J, Guo Z, Wu G, Wang C, Xu K, Huang R, Kuang Q, Qu L, Pan C, Xie X, Zhu Q, Huang J, Lin Q.   +22 more
europepmc   +2 more sources

Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5  proteins including human TRIM5 [PDF]

, 2009
The potential risk of cross-species transmission of porcine endogenous retroviruses (PERV) to humans has slowed the development of xenotransplantation, using pigs as organ donors. Here, we show that PERVs are insensitive to restriction by divergent TRIM5{
Takeuchi, Y., Schaller, T., Towers, G. J., Wood, A., Webb, B. L. J., Bartosch, B.   +5 more
core  

A Closed‐Loop Framework for Inverse Design: Dynamic Training and Intelligent Optimization for Heterostructured Materials

Advanced Science, EarlyView.
To accelerate the inverse design of heterostructured metal matrix composites, a closed‐loop scientific machine learning framework integrates continual learning prediction with NSGA‐II‐PMCP optimization. The framework maps microstructural descriptors to strength, toughness, and modulus, expands high‐quality Pareto solutions, and guides experimentally ...
Zhiyan Zhong, Xueru Zheng, Xiao Zhou, Zhengheng Tao, Wan Han, Jingyi Pan, Dian Wu, Ning Gao, Lei Liu, Zhongyang Wang, Fanchao Meng, Tongxiang Fan   +11 more
wiley   +1 more source