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Eliminating helper phage from phage display [PDF]
Nucleic Acids Research, 2006 Phage display technology involves the display of proteins or peptides, as coat protein fusions, on the surface of a phage or phagemid particles. Using standard technology, helper phage are essential for the replication and assembly of phagemid particles, during library production and biopanning. We have eliminated the need to add helper phage by using '
Andrew Bradbury +3 more
openaire +9 more sources
Developing Recombinant Antibodies by Phage Display Against Infectious Diseases and Toxins for Diagnostics and Therapy [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 Antibodies are essential molecules for diagnosis and treatment of diseases caused by pathogens and their toxins. Antibodies were integrated in our medical repertoire against infectious diseases more than hundred years ago by using animal sera to treat ...
Stephan Steinke +2 more
exaly +4 more sources
Phage Display Technology in Biomarker Identification with Emphasis on Non-Cancerous Diseases. [PDF]
MoleculesIn recent years, phage display technology has become vital in clinical research. It helps create antibodies that can specifically bind to complex antigens, which is crucial for identifying biomarkers and improving diagnostics and treatments.
Sadraeian M +3 more
europepmc +3 more sources
Phage Display Informatics [PDF]
Computational and Mathematical Methods in Medicine, 2013 Phage display is an efficient laboratory technique that can be used to screen for specific peptides and proteins displayed on the surface of bacteriophage. Since Professor George Smith of the University of Missouri pioneered the powerful and flexible method in 1980s [1], it has been adapted and improved by many scientists from various fields.
Jian Huang, Ratmir Derda, Yanxin Huang
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Evaluation of Phage Display Discovered Peptides as Ligands for Prostate-Specific Membrane Antigen (PSMA) [PDF]
, 2013 The aim of this study was to identify potential ligands of PSMA suitable for further development as novel PSMA-targeted peptides using phage display technology. The human PSMA protein was immobilized as a target followed by incubation with a 15-mer phage
A Ghosh +48 more
core +17 more sources
Phage Display-Based Nanotechnology Applications in Cancer Immunotherapy [PDF]
, 2020 Phage display is a nanotechnology with limitless potential, first developed in 1985 and still awaiting to reach its peak. Awarded in 2018 with the Nobel Prize for Chemistry, the method allows the isolation of high-affinity ligands for diverse substrates,
Goracci, Martina +2 more
core +1 more source
Use of in vivo phage display to engineer novel adenoviruses for targeted delivery to the cardiac vasculature [PDF]
, 2009 We performed in vivo phage display in the stroke prone spontaneously hypertensive rat, a cardiovascular disease model, and the normotensive Wistar Kyoto rat to identify cardiac targeting peptides, and then assessed each in the context of viral gene ...
Andrew H. Baker +26 more
core +1 more source
Microbiology Spectrum, 2015 ABSTRACT Despite the availability of antimicrobial drugs, the continued development of microbial resistance—established through escape mutations and the emergence of resistant strains—limits their clinical utility. The discovery of novel, therapeutic, monoclonal antibodies (mAbs) offers viable clinical alternatives in the ...
Jared Sheehan, Wayne A. Marasco
openaire +2 more sources
Mimotope mapping as a complementary strategy to define allergen IgE-epitopes: peach Pru p 3 allergen as a model. [PDF]
, 2008 Lipid transfer proteins (LTPs) are the major allergens of Rosaceae fruits in the Mediterranean area. Pru p 3, the LTP and major allergen of peach, is a suitable model for studying food allergy and amino acid sequences related with its IgE-binding ...
Compes, Esther +7 more
core +2 more sources