Results 11 to 20 of about 150,978 (251)

Cross-resistance is modular in bacteria-phage interactions. [PDF]

PLoS Biology, 2018
Phages shape the structure of natural bacterial communities and can be effective therapeutic agents. Bacterial resistance to phage infection, however, limits the usefulness of phage therapies and could destabilise community structures, especially if ...
Rosanna C T Wright, Ville-Petri Friman, Margaret C M Smith, Michael A Brockhurst   +3 more
doaj   +7 more sources

An Assessment of the Viability of Lytic Phages and Their Potency against Multidrug Resistant Escherichia coli O177 Strains under Simulated Rumen Fermentation Conditions

Antibiotics, 2021
Preslaughter starvation and subacute ruminal acidosis in cattle are known to promote ruminal proliferation of atypical enteropathogenic Escherichia coli strains, thereby increasing the risk of meat and milk contamination. Using bacteriophages (henceforth
Peter Kotsoana Montso, Caven Mguvane Mnisi, Collins Njie Ateba, Victor Mlambo   +3 more
doaj   +1 more source

Distribution of Important Probiotic Genes and Identification of the Biogenic Amines Produced by Lactobacillus acidophilus PNW3

Foods, 2020
The genome of Lactobacillus acidophilus PNW3 was assessed for probiotic and safety potentials. The genome was completely sequenced, assembled using SPAdes, and thereafter annotated with NCBI prokaryotic genome annotation pipeline (PGAP) and rapid ...
Kazeem Adekunle Alayande, Olayinka Ayobami Aiyegoro, Collins Njie Ateba   +2 more
doaj   +1 more source

Genotypic and Phenotypic Evaluation of Biofilm Production and Antimicrobial Resistance in Staphylococcus aureus Isolated from Milk, North West Province, South Africa

Antibiotics, 2020
Background: Biofilm formation in S. aureus may reduce the rate of penetration of antibiotics, thereby complicating treatment of infections caused by these bacteria.
Marie Ebob Agbortabot Bissong, Collins Njie Ateba   +1 more
doaj   +1 more source

Characterization of Phage Resistance and Their Impacts on Bacterial Fitness in Pseudomonas aeruginosa

Microbiology Spectrum, 2022
The emergence and spread of antibiotic resistance pose serious environmental and health challenges. Attention has been drawn to phage therapy as an alternative approach to combat antibiotic resistance with immense potential. However, one of the obstacles
Na Li, Yigang Zeng, Mengran Wang, Rong Bao, Yu Chen, Xiaoyu Li, Jue Pan, Tongyu Zhu, Bijie Hu, Demeng Tan   +9 more
doaj   +1 more source

The therapeutic potential of bacteriophages targeting gram-negative bacteria using Galleria mellonella infection model

BMC Microbiology, 2018
Background Phage therapy is the therapeutic use of bacteriophages to treat highly drug resistant bacterial infections. The current surge in bacteriophage therapy is motivated mainly because of the emergence of antibiotic-resistant bacteria in clinics ...
Prasanth Manohar, Ramesh Nachimuthu, Bruno S. Lopes   +2 more
doaj   +1 more source

Greater Phage Genotypic Diversity Constrains Arms-Race Coevolution

Frontiers in Cellular and Infection Microbiology, 2022
Antagonistic coevolution between hosts and parasites, the reciprocal evolution of host resistance and parasite infectivity, has important implications in ecology and evolution.
Meaghan Castledine, Pawel Sierocinski, Mhairi Inglis, Suzanne Kay, Alex Hayward, Angus Buckling, Daniel Padfield   +6 more
doaj   +1 more source

Characterization of phage resistance and phages capable of intestinal decolonization of carbapenem-resistant Klebsiella pneumoniae in mice [PDF]

Communications Biology, 2022
AbstractCarbapenem-resistant Klebsiella pneumoniae (CRKP) has emerged as a severe global health challenge. We isolate and characterize two previously unidentified lytic phages, P24 and P39, with large burst sizes active against ST11 KL64, a major CRKP lineage.
Qingqing Fang, Yu Feng, Alan McNally, Zhiyong Zong   +3 more
openaire   +3 more sources

Parallel evolution of Pseudomonas aeruginosa phage resistance and virulence loss in response to phage treatment in vivo and in vitro

eLife, 2022
With rising antibiotic resistance, there has been increasing interest in treating pathogenic bacteria with bacteriophages (phage therapy). One limitation of phage therapy is the ease at which bacteria can evolve resistance. Negative effects of resistance
Meaghan Castledine, Daniel Padfield, Pawel Sierocinski, Jesica Soria Pascual, Adam Hughes, Lotta Mäkinen, Ville-Petri Friman, Jean-Paul Pirnay, Maya Merabishvili, Daniel de Vos, Angus Buckling   +10 more
doaj   +1 more source

Phage Resistance in Multidrug-Resistant Klebsiella pneumoniae ST258 Evolves via Diverse Mutations That Culminate in Impaired Adsorption

mBio, 2020
The evolution of phage resistance poses an inevitable threat to the efficacy of phage therapy. The strategic selection of phage combinations that impose high genetic barriers to resistance and/or high compensatory fitness costs may mitigate this threat ...
Shayla Hesse, Manoj Rajaure, Erin Wall, Joy Johnson, Valery Bliskovsky, Susan Gottesman, Sankar Adhya   +6 more
doaj   +1 more source