Results 31 to 40 of about 150,978 (251)

Phages Needed against Resistant Bacteria [PDF]

Viruses, 2020
Phages have been known for more than 100 years. They have been applied to numerous infectious diseases and have proved to be effective in many cases. However, they have been neglected due to the era of antibiotics. With the increase of antibiotic-resistant microorganisms, we need additional therapies.
openaire   +4 more sources

Molecular Basis for Lytic Bacteriophage Resistance in Enterococci

mBio, 2016
The human intestine harbors diverse communities of bacteria and bacteriophages. Given the specificity of phages for their bacterial hosts, there is growing interest in using phage therapies to combat the rising incidence of multidrug-resistant bacterial ...
Breck A. Duerkop, Wenwen Huo, Pooja Bhardwaj, Kelli L. Palmer, Lora V. Hooper   +4 more
doaj   +1 more source

Spontaneous Phage Resistance in Avian Pathogenic Escherichia coli

Frontiers in Microbiology, 2021
Avian pathogenic Escherichia coli (APEC) is one of the most important bacterial pathogens affecting poultry worldwide. The emergence of multidrug-resistant pathogens has renewed the interest in the therapeutic use of bacteriophages (phages).
Patricia E. Sørensen, Patricia E. Sørensen, Sharmin Baig, Marc Stegger, Hanne Ingmer, An Garmyn, Patrick Butaye, Patrick Butaye   +7 more
doaj   +1 more source

Characterization of an Enterococcus faecalis Bacteriophage vB_EfaM_LG1 and Its Synergistic Effect With Antibiotic

Frontiers in Cellular and Infection Microbiology, 2021
Enterococcus faecalis is a Gram-positive opportunistic pathogen that could cause pneumonia and bacteremia in stroke patients. The development of antibiotic resistance in hospital-associated E. faecalis is a formidable public health threat.
Min Song, Dongmei Wu, Yang Hu, Haiyan Luo, Gongbo Li   +4 more
doaj   +1 more source

Molecular characterization and safety properties of multi drug-resistant Escherichia coli O157:H7 bacteriophages

BMC Microbiology
The increase in multi drug resistance (MDR) amongst food-borne pathogens such as Escherichia coli O157:H7, coupled with the upsurge of food-borne infections caused by these pathogens is a major public health concern. Lytic phages have been employed as an
Bukola Opeyemi Oluwarinde, Daniel Jesuwenu Ajose, Tesleem Olatunde Abolarinwa, Peter Kotsoana Montso, Henry Akum Njom, Collins Njie Ateba   +5 more
doaj   +1 more source

Resistance Evolution against Phage Combinations Depends on the Timing and Order of Exposure

mBio, 2019
Phage therapy is a promising alternative to chemotherapeutic antibiotics for the treatment of bacterial infections. However, despite recent clinical uses of combinations of phages to treat multidrug-resistant infections, a mechanistic understanding of ...
Rosanna C. T. Wright, Ville-Petri Friman, Margaret C. M. Smith, Michael A. Brockhurst   +3 more
doaj   +1 more source

Extended Spectrum Beta-Lactamase-Resistant Determinants among Carbapenem-Resistant Enterobacteriaceae from Beef Cattle in the North West Province, South Africa: A Critical Assessment of Their Possible Public Health Implications

Antibiotics, 2020
Carbapenems are considered to be the last resort antibiotics for the treatment of infections caused by extended-spectrum beta-lactamase (ESBL)-producing strains.
Lungisile Tshitshi, Madira Coutlyne Manganyi, Peter Kotsoana Montso, Moses Mbewe, Collins Njie Ateba   +4 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Efficacy of a phage cocktail in controlling phage resistance development in multidrug resistant Acinetobacter baumannii

Virus Research, 2019
The control and treatment of multidrug resistant pathogens infections has become a grand challenge for clinicians worldwide. Virulent phage has long been considered as an effective bactericidal agent, which may be a potentially alternative to antibiotics.
Yuyu, Yuan, Lili, Wang, Xiaoyu, Li, Demeng, Tan, Cong, Cong, Yongping, Xu   +5 more
openaire   +2 more sources

Comparative metabolomics revealed key pathways associated with the synergistic killing of multidrug-resistant Klebsiella pneumoniae by a bacteriophage-polymyxin combination

Computational and Structural Biotechnology Journal, 2022
Resistance to the last-line polymyxins is emerging in multidrug-resistant Klebsiella pneumoniae and phage therapy is a promising alternative. However, phage monotherapy often rapidly causes resistance and few studies have examined antibiotic-phage ...
Mei-Ling Han, Sue C. Nang, Yu-Wei Lin, Yan Zhu, Heidi H. Yu, Hasini Wickremasinghe, Christopher K. Barlow, Darren J. Creek, Simon Crawford, Gauri Rao, Chongshan Dai, Jeremy J. Barr, Kim Chan, Robert Turner Schooley, Tony Velkov, Jian Li   +15 more
doaj   +1 more source