Results 21 to 30 of about 150,978 (251)
Microbiology Spectrum, 2023 The spread of multidrug resistant and hypervirulent Klebsiella pneumoniae has recently increased. Phages have been considered alternatives for treating infections caused by tenacious pathogens.
Huaixin Geng +7 more
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Phage Products for Fighting Antimicrobial Resistance
Microorganisms, 2022 Antimicrobial resistance (AMR) has become a global public health issue and antibiotic agents have lagged behind the rise in bacterial resistance. We are searching for a new method to combat AMR and phages are viruses that can effectively fight bacterial infections, which have renewed interest as antibiotic alternatives with their specificity.
Yuanling Huang +6 more
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Frontiers in Microbiology, 2019 Infections due to antibiotic resistant bacteria are increasing globally and this needs immediate attention. Bacteriophages are considered an effective alternative for the treatment of bacterial infections.
Prasanth Manohar +4 more
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Identification of the Genetic Basis of Phage Resistance in Sequentially Generated Phage-Resistant <i>Klebsiella pneumoniae</i> Using an Established Phage Library. [PDF]
Antibiotics (Basel)Objectives: To explore the genetic basis of phage resistance in sequentially generated capsular mutants of phage-resistant Klebsiella pneumoniae using an established phage library. Methods: Sequential induction strategies were employed to obtain phage-resistant K. pneumoniae capsular mutants by exposing ST11-K64 K. pneumoniae Kp2325 to different single
Zhao W +8 more
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Phage-resistant and phage-carrying strains of lactic streptococci [PDF]
Journal of Hygiene, 1947 1. The types of resistance acquired by certain related strains of Str. cremoris as a result of phage action were investigated.2. Some partially resistant forms of Str. cremoris were able to ‘carry’ phage in symbiotic association when subcultured daily in milk for long periods of time.3.
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Biofilm Structure Promotes Coexistence of Phage-Resistant and Phage-Susceptible Bacteria [PDF]
mSystems, 2020 In the natural environment, bacteria most often live in communities bound to one another by secreted adhesives. These communities, or biofilms, play a central role in biogeochemical cycling, microbiome functioning, wastewater treatment, and disease. Wherever there are bacteria, there are also viruses that attack them, called phages.
Simmons, Emilia L. +5 more
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Improving phage therapy by evasion of phage resistance mechanisms. [PDF]
JAC Antimicrob Resist, 2023 Abstract Antibiotic failure is one of the most worrisome threats to global health. Among the new therapeutic efforts that are being explored, the use of bacteriophages (viruses that kill bacteria), also known as ‘phages’, is being extensively studied as a strategy to target bacterial pathogens. However, one of the main drawbacks of phage
Bleriot I +10 more
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Microbiology Spectrum, 2022 In order to establish phage therapy as a standard clinical treatment for bacterial infections, testing of every phage to ensure the suitability and safety of the biological compound is required.
Prasanth Manohar +5 more
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The impact of phage and phage resistance on microbial community dynamics. [PDF]
PLoS Biol, 2023 Where there are bacteria, there will be bacteriophages. These viruses are known to be important players in shaping the wider microbial community in which they are embedded, with potential implications for human health. On the other hand, bacteria possess a range of distinct immune mechanisms that provide protection against ...
Alseth EO +5 more
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Pharmaceuticals, 2021 Phage therapy is the use of bacterial viruses as antibacterial agents. A primary consideration for commercial development of phages for phage therapy is the number of different bacterial strains that are successfully targeted, as this defines the breadth
Stephen T. Abedon +2 more
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