Results 101 to 110 of about 24,581 (324)

Novel Sulfonium Reagents for the Modular Synthesis of Spiro[2.3]Hexanes and Heteroatom‐Containing Analogues: Synthesis, Application, and Evaluation as Bioisosteres

Angewandte Chemie, EarlyView.
Strained spirocyclic spiro[2.3]hexane and its heteroatom‐containing derivatives, including previously underrepresented 5‐oxa‐1‐azaspiro[2.3]hexanes and 1,5‐diazaspiro[2.3]hexanes, were synthesized via a modular approach of insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into alkenes, carbonyls and imines.
Philipp Natho, Annarita Vicenti, Fabrizio Mastrolorito, Francesca De Franco, Lee Walsh‐Benn, Marco Colella, Ernesto Mesto, Emanuela Schingaro, Orazio Nicolotti, Antimo Gioiello, Renzo Luisi   +10 more
wiley   +2 more sources

Nickel-Catalyzed Asymmetric Reductive Cross-Coupling between Heteroaryl Iodides and α-Chloronitriles [PDF]

, 2015
A Ni-catalyzed asymmetric reductive cross-coupling of heteroaryl iodides and α-chloronitriles has been developed. This method furnishes enantioenriched α,α-disubstituted nitriles from simple organohalide building blocks.
Kadunce, Nathaniel T., Reisman, Sarah E.
core   +4 more sources

Strategies for Paired Electrolysis with Enhanced Efficiency

Advanced Energy and Sustainability Research, EarlyView.
This review summarizes the fundamentals, challenges, and strategies for paired electrolysis, with examples in the chlor‐alkali, hydrogen production, CO2 reduction, and ammonia synthesis industries. Future directions include the development of advanced membranes, computational studies, process integration, scale‐up, and techno‐economic analysis.
Yuanyuan Yao, Xin Yang, Yuqi Pan, Leo Lai, Liuyue Cao, Li Wei, Yuan Chen   +6 more
wiley   +1 more source

Macrocyclic Molecular Glues for the 14‐3‐3/ChREBP Interaction: Affinity and Cooperativity in an Inverse Relationship

Angewandte Chemie, EarlyView.
Macrocycles are effective molecular glues to stabilize the 14‐3‐3/ChREBP interaction. Linker length modulation uncovered an inverse correlation between the macrocycle binding affinity to 14‐3‐3 and its cooperativity in 14‐3‐3/ChREBP stabilization.
Marloes A. M. Pennings, Merel A. W. van den Bosch, Ansgar Oberheide, Carlo J. A. Verhoef, Christian Ottmann, Albert J. Markvoort, Galen P. Miley, Luc Brunsveld   +7 more
wiley   +2 more sources

Studies on the C-C Bond Formation Methods Based on the Activation of Secondary Amides and the Asymmetric Total Synthesis of Cylindricine D [PDF]

, 2016
有机合成方法学和天然产物全合成是有机化学的两个重要分支，直接推动并促进有机化学及药物研发等相关学科领域的发展。 本论文包含两方面的工作，一是发展基于仲酰胺活化形成C–C键方法学的研究，二是拓展叔酰胺一瓶双烷基化构筑N-杂季碳的方法学应用到Cylindricine类生物碱的不对称合成研究。 酰胺是一类重要的有机合成和药物合成中间体，也构成了蛋白质的主要结构特征。此外，酰胺基常用作胺的保护基、C–H活化反应的活化定位基团。然而，酰胺高度稳定，羰基的反应活性非常低。因此 ...
黄应红
core  

Highly enantioselective hydroamination to six-membered rings by heterobimetallic catalysts [PDF]

, 2014
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence
Biyikal, Mustafa, Blechert, Siegfried, Hussein, Lenard, Purkait, Nibadita, Roesky, Peter W., Tausch, Eugenia   +5 more
core   +1 more source

18F‐Radiopharmaceutical Diversification Enabled by Deaminative Cross‐Electrophile Couplings

Angewandte Chemie, EarlyView.
A general Ni‐mediated (C)sp2–(C)sp3 cross‐coupling expedites access to 18F‐radiopharmaceuticals, essential for positron emission tomography imaging and drug discovery. This late‐stage diversification approach was implemented across three user‐friendly automated protocols affording 18F‐radiotracers in sufficient quantities for imaging.
Isabella F. Ogilvy, Joseph Ford, Sebastiano Ortalli, Evelien Renders, Thomas R. Hayes, Shuanglong Liu, Inne Mortiers, Anastasia Nikolopoulou, Alexandre M. Sorlin, Andrés A. Trabanco, Matthew Tredwell, Peter J. J. A. Buijnsters, Rhys Salter, Véronique Gouverneur   +13 more
wiley   +2 more sources

Oxalates as Activating Groups for Alcohols in Visible Light Photoredox Catalysis: Formation of Quaternary Centers by Redox-Neutral Fragment Coupling. [PDF]

, 2015
Alkyl oxalates are new bench-stable alcohol-activating groups for radical generation under visible light photoredox conditions. Using these precursors, the first net redox-neutral coupling of tertiary and secondary alcohols with electron-deficient ...
Jamison, Christopher R, MacMillan, David WC, Nawrat, Christopher C, Overman, Larry E, Slutskyy, Yuriy   +4 more
core  

Prins fluorination cyclisations: Preparation of 4-fluoro-pyran and -piperidine heterocycles

Beilstein Journal of Organic Chemistry, 2010
The Prins reaction was investigated using BF3·OEt2 as a Lewis acid. It has been recently demonstrated, that if BF3·OEt2 is used in stoichiometric amounts then these reactions generate fluorinated products where the BF3·OEt2 contributes fluoride ion to ...
Guillaume G. Launay, Alexandra M. Z. Slawin, David O'Hagan   +2 more
doaj   +1 more source

Pentannulation of N-heterocycles by a tandem gold-catalyzed [3,3]-rearrangement/Nazarov reaction of propargyl ester derivatives: a computational study on the crucial role of the nitrogen atom

Beilstein Journal of Organic Chemistry, 2020
The tandem gold(I)-catalyzed rearrangement/Nazarov reaction of enynyl acetates in which the double bond is embedded in a piperidine ring was computationally and experimentally studied.
Giovanna Zanella, Martina Petrović, Dina Scarpi, Ernesto G. Occhiato, Enrique Gómez-Bengoa   +4 more
doaj   +1 more source