Results 101 to 110 of about 23,915 (334)
Advanced Science, EarlyView.The cRGD‐ILD molecular probe integrates clinically available components: a cRGD peptide (integrin αvβ3 targeting), ICG (for fluorescence/photoacoustic imaging and phototherapy), and Gd‐DTPA (MRI contrast). Utilizing small size and receptor targeting, it achieves selective lesion accumulation.
Qiyu Zhong +9 more
wiley +1 more source
Angewandte Chemie, EarlyView.A dimethylsulfoniopropionate lyase (DddK) was identified as an efficient aza‐Michaelase for the addition of amines to acrylate. Screening 74 amines with wild‐type DddK and its W26G variant yielded N‐substituted and N,N‐disubstituted β‐amino acids in 30%–93% isolated yield.
Diletta Arceri +5 more
wiley +2 more sources
New One-Pot Methodologies for the Modification or Synthesis of Alkaloid Scaffolds
Marine Drugs, 2010 There are several avenues by which promising bioactive natural products can be produced in sufficient quantities to enable lead optimization and medicinal chemistry studies. The total synthesis of natural products is an important, but sometimes difficult,
Amir E. Wahba, Mark T. Hamann
doaj +1 more source
Studies on the C-C Bond Formation Methods Based on the Activation of Secondary Amides and the Asymmetric Total Synthesis of Cylindricine D [PDF]
, 2016 有机合成方法学和天然产物全合成是有机化学的两个重要分支，直接推动并促进有机化学及药物研发等相关学科领域的发展。 本论文包含两方面的工作，一是发展基于仲酰胺活化形成C–C键方法学的研究，二是拓展叔酰胺一瓶双烷基化构筑N-杂季碳的方法学应用到Cylindricine类生物碱的不对称合成研究。 酰胺是一类重要的有机合成和药物合成中间体，也构成了蛋白质的主要结构特征。此外，酰胺基常用作胺的保护基、C–H活化反应的活化定位基团。然而，酰胺高度稳定，羰基的反应活性非常低。因此 ...
黄应红
core
Nickel-Catalyzed Asymmetric Reductive Cross-Coupling between Heteroaryl Iodides and α-Chloronitriles [PDF]
, 2015 A Ni-catalyzed asymmetric reductive cross-coupling of heteroaryl iodides and α-chloronitriles has been developed. This method furnishes enantioenriched α,α-disubstituted nitriles from simple organohalide building blocks.
Kadunce, Nathaniel T., Reisman, Sarah E.
core +4 more sources
Achieving High Energy Density in Aqueous Zinc‐Ion Batteries
Advanced Energy Materials, EarlyView.Aqueous zinc‐ion batteries (AZIBs) offer high safety, cost‐effectiveness, and environmental benefits, yet achieving high energy density remains a challenge. This review explores advances in cathodes, zinc anodes, separators, and electrolytes to enhance energy density. It also discusses scalability and future directions, highlighting AZIBs potential for
Chun‐Chuan Kao +5 more
wiley +1 more source
Advanced Energy Materials, EarlyView.Layered halide double perovskites have emerged as promising alternatives to toxic lead‐based low‐dimensional perovskite materials for more sustainable optoelectronics. Their molecular design and its impact on the material characteristics, as well as the resulting functionality, is reviewed while discussing challenges and opportunities for future ...
Maryam Ghasemi +4 more
wiley +1 more source
Angewandte Chemie, EarlyView.We developed potent and selective noncovalent Keap1‐Nrf2 inhibitors through a structure‐guided fragment‐based approach. These nanomolar inhibitors activate Nrf2‐controlled genes, suppress inflammation via NLRP3 and STING pathways, and exhibit distinct transcriptional profiles compared to covalent Nrf2 activators, offering promising chemical probes and ...
Chunyu Lin +23 more
wiley +2 more sources
Opportunities and challenges for direct C–H functionalization of piperazines
Beilstein Journal of Organic Chemistry, 2016 Piperazine ranks within the top three most utilized N-heterocyclic moieties in FDA-approved small-molecule pharmaceuticals. Herein we summarize the current synthetic methods available to perform C–H functionalization on piperazines in order to lend ...
Zhishi Ye, Kristen E. Gettys, Mingji Dai
doaj +1 more source
Highly enantioselective hydroamination to six-membered rings by heterobimetallic catalysts [PDF]
, 2014 Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence
Biyikal, Mustafa +5 more
core +1 more source