Results 191 to 200 of about 53,758 (224)

Applied RNAi

Frontiers in Genetics, 2014
Bernard eMari, Barbara eBardoni
doaj   +1 more source

Preferential Solvation by Trifluoroethanol Drives α‐Helical Folding in the Disordered S2 Region of the Escargot Protein

ChemPhysChem, Volume 27, Issue 3, February 2026.
A disordered S2 region of the Escargot protein forms helices which are stabilized by TFE and are correlated with molecular recognition. The N‐terminal domain of the Drosophila melanogaster Escargot transcription factor (Esg) is an intrinsically disordered region (IDR) that complements the DNA‐binding activity of its C‐terminal zinc fingers. Within this
Vinicius Piccoli, Ander F. Pereira, Lina Rivillas‐Acevedo, Nina Pastor, Ángel E. Peláez‐Aguilar, Leandro Martínez   +5 more
wiley   +1 more source

High‐throughput single‐cell DNA methylation and chromatin accessibility co‐profiling with SpliCOOL‐seq

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
SpliCOOL‐seq achieves high‐throughput single‐cell co‐profiling of DNA methylation and chromatin accessibility. DNMT inhibitors caused cancer cell demethylation with divergent patterns. SpliCOOL‐seq enables the discovery of genes related to LUAD tumorigenesis. Ageing and LUAD tumorigenesis may share similar epigenetic alterations.
Qingmei Shen, Enze Deng, Ling Luo, Jingna Zhang, Qifeng Yang, Dan Su, Xiaoying Fan   +6 more
wiley   +1 more source

Dynamic Gelatin Hydrogels Crosslinked by Dithiolane‐Norbornene Click Chemistry

Macromolecular Bioscience, Volume 26, Issue 2, February 2026.
Gelatin‐norbornene (GelNB) and poly(ethylene glycol)‐tetra‐lipoic acid (PEG4LA) are modularly photo‐crosslinked into gelatin‐based hydrogels with dynamically tunable mechanics for expansion and differentiation of induced pluripotent stem cells (iPSC). ABSTRACT Hydrogels prepared from gelatin are ideal for mimicking the extracellular matrix (ECM) owing ...
Favour O. Afolabi, Lydia Yang He, Chien‐Chi Lin   +2 more
wiley   +1 more source

Applications of Multifunctional Hydrogel in Tissue Engineering and Regenerative Medicine

MedComm, Volume 7, Issue 2, February 2026.
Schematic illustration showing multifunctional hydrogels in the application of tissue engineering and regenerative medicine. ABSTRACT Hydrogels, with excellent hydrophilicity and high‐water content, have emerged as highly versatile biomaterials for tissue engineering and regenerative medicine.
Jieran Lyu, Xuemiao Liu, Qiqi Yang, Yuchang Zhang, Xing Wang   +4 more
wiley   +1 more source

Oligodendrocyte: Development, Plasticity, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
The oligodendrocyte lineage and its roles in development, plasticity, and CNS homeostasis have been shown to have the potential to treat neurological diseases. However, the main obstacles to clinical translation, particularly in terms of BBB challenges and precise delivery.
Qiong Xiang, Ruo‐Lan Shi, You‐Xia Huang, Li‐Ni Liu, Jia‐Sheng Tao, Xian‐Hui Li, Xiao‐Da Li   +6 more
wiley   +1 more source

Molecular alterations in high‐grade neuroendocrine tumors of the small intestine

The Journal of Pathology, Volume 268, Issue 2, Page 215-226, February 2026.
Abstract High‐grade neuroendocrine tumors of the small intestine are separated into two groups: well‐differentiated neuroendocrine tumors (NETs, high‐grade) and poorly differentiated neuroendocrine carcinomas (NECs). They represent very rare entities, with few molecular data available, and are very challenging to treat.
Agathe Hercent, Julien Masliah‐Planchon, David Cohen, Remy Nicolle, Jean‐Yves Scoazec, Philippe Ruszniewski, Ivan Bièche, Louis de Mestier, Anne Couvelard, Jerome Cros   +9 more
wiley   +1 more source

Biotechnical Multiscale Engineering of Scaffolds for Stem Cell and Organoid Research

Small, Volume 22, Issue 12, 25 February 2026.
Biotechnical multiscale engineering consideration of geometric and structural parameters, which is called biotechnical multiscale engineering, has an influence on stem cell development and organogenesis comparable to that of molecular genetics and biochemical parameters.
Merle‐Johanna Küstner, Christian Marx, Peter beim Graben, Serafim Rodrigues, Jörg Hampl, Frank Weise, Michael Gebinoga, Leon Kaysan, Maren Klett, Dana Brauer, Gregor Schlingloff, Doris Heinrich, Insa Sigrid Schroeder, Andreas Schober   +13 more
wiley   +1 more source

In Vivo Chemical Reprogramming Is Associated With a Toxic Accumulation of Lipid Droplets Hindering Rejuvenation

Aging Cell, Volume 25, Issue 2, February 2026.
Partial chemical reprogramming significantly increases mitochondrial interaction networks, affects mitochondrial morphology, speeds up mitochondrial movement dynamics, increases mitochondrial transmembrane potential, and induces TCA cycle stress. These changes in mitochondrial function contribute to lipid droplet accumulation, acute kidney injury, and ...
Wayne Mitchell, Cecília G. de Magalhães, Alexander Tyshkovskiy, Yushi Uchida, Ludger J. E. Goeminne, Takaharu Ichimura, Emery L. Ng, Alibek Moldakozhayev, Joseph V. Bonventre, Vadim N. Gladyshev   +9 more
wiley   +1 more source

The HIF‐1α Pathway Regulates Satellite Cell Fate During Aging Through Histone Lactylation

Aging Cell, Volume 25, Issue 2, February 2026.
FG‐4592–induced activation of HIF‐1α enhances anaerobic glycolysis and promotes lactate‐driven PAX7 lactylation, thereby boosting satellite cell activity and counteracting age‐related muscle decline. ABSTRACT Aging‐associated sarcopenia is driven in part by the progressive loss of type II glycolytic fibers and the functional decline of their resident ...
Marco Piccoli, Lorenzo Mornatti, Ivana Lavota, Monica Risuglia, Pasquale Creo, Elena Vizzino, Paola Rota, Adriana Tarantino, Laura Mangiavini, Giuseppe Ciconte, Paola Signorelli, Giuseppe Maria Peretti, Simone Cenci, Carlo Pappone, Luigi Anastasia, Federica Cirillo   +15 more
wiley   +1 more source