Results 101 to 110 of about 30,090 (224)
Interfacial Energy and Composition Controlled Self‐Stratification in Polyurethane Coatings
Macromolecular Materials and Engineering, EarlyView.This study elucidates self‐stratification in polyurethane coatings driven by interfacial energies and composition‐dependent phase separation. Using XPS, SIMS, and Raman analyses, we reveal rapid formation of hydrophobic and hydrophilic layers and substrate‐dependent interfacial structures.
Gaurav Singhal +11 more
wiley +1 more source
Molecular Carcinogenesis, EarlyView.ABSTRACT Early diagnosis of acute promyelocytic leukemia (APL), driven by PML‐RARA oncoprotein, is vital for survival, as delays can cause fatal coagulopathy without prompt therapeutic intervention of all‐trans retinoic acid and arsenic trioxide. Although APL is diagnosed using microscopy, immunophenotyping, and FISH/PCR for PML‐RARA, morphological ...
Akash Maity +17 more
wiley +1 more source
Small Methods, EarlyView.Triboelectrification‐driven self‐assembly of dry colloidal powder offers a promising dry approach to rapidly (<20$<20$ s) attain ordered monolayer colloidal particles for surface‐enhanced Raman spectroscopy applications. ABSTRACT Surface‐enhanced Raman spectroscopy (SERS) amplifies Raman signals on nanostructured metallic surfaces, enabling the ...
Mehdi Feizpour +4 more
wiley +1 more source
Allergy, EarlyView.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter +20 more
wiley +1 more source
Optical genome mapping detects cryptic high‐risk and targetable abnormalities in adult AML
British Journal of Haematology, EarlyView.Summary Acute myeloid leukaemia (AML) risk stratification relies on cytogenetic and molecular abnormalities defined by European LeukemiaNet (ELN) 2022. Conventional cytogenetic techniques, including chromosomal banding analysis (CBA) and fluorescence in situ hybridization, have limited resolution and may miss cryptic events. Optical genome mapping (OGM)
Audrey Bidet +10 more
wiley +1 more source
Cancer Science, EarlyView.FBMTG‐APL2017: First prospective multicenter trial evaluating frontline ATRA‐ATO therapy for newly diagnosed APL in Japan, encompassing both low–intermediate (n = 65) and high‐risk (n = 16) patients. Excellent outcomes (95% CR, 94% 3‐year DFS) with comparable efficacy between risk groups (DFS: 97% vs.
Ken Takase +14 more
wiley +1 more source
European Journal of Haematology, EarlyView.SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley +1 more source
International Journal of Biological Sciences, 2010 Promyelocytic Leukaemia Protein nuclear bodies (PML-NBs) are dynamic nuclear protein aggregates. To gain insight in PML-NB function, reductionist and high throughput techniques have been employed to identify PML-NB proteins.
Ellen Van Damme, Kris Laukens, Thanh Hai Dang, Xaveer Van Ostade
doaj
The FEBS Journal, EarlyView.Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna +5 more
wiley +1 more source