Enhanced podocalyxin expression alters the structure of podocyte basal surface [PDF]
Journal of Cell Science, 2004 Glomerular basement membrane (GBM) and podocalyxin are essential for podocyte morphology. We provide evidence of functional interconnections between basement membrane components (collagen IV and laminin), the expression of podocalyxin and the morphology of human glomerular epithelial cells (podocytes).
Economou, CG +7 more
openaire +3 more sources
Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1 [PDF]
, 2017 Peer ...
Alitalo, Kari +7 more
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Urinary podocyte-associated mRNA profile in various stages of diabetic nephropathy. [PDF]
PLoS ONE, 2011 BACKGROUND: Podocyte injury and subsequent excretion in urine play a crucial role in the pathogenesis and progression of diabetic nephropathy (DN). Quantification of messenger RNA (mRNA) expression in urinary sediment by real-time PCR is emerging as a ...
Min Zheng +6 more
doaj +1 more source
Nanoscale protein architecture of the kidney glomerular basement membrane [PDF]
, 2013 In multicellular organisms, proteins of the extracellular matrix (ECM) play structural and functional roles in essentially all organs, so understanding ECM protein organization in health and disease remains an important goal.
Dani, Adish +6 more
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Frontiers in Oncology, 2022 Podocalyxin (Podxl) is a CD34-related cell surface sialomucin that is normally highly expressed by adult vascular endothelia and kidney podocytes where it plays a key role in blocking adhesion.
Diana Canals Hernaez +13 more
doaj +1 more source
Detection of podocyturia in patients with lupus nephritis [PDF]
, 2013 INTRODUCTION: The podocyturia has been detected in glomerular diseases, such as lupus nephritis (LN), in which proteinuria is an important manifestation, and its occurrence seems to be limited to the active phase of the disease.
Mansur, Juliana Busato +5 more
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The cell surface mucin podocalyxin regulates collective breast tumor budding [PDF]
Breast Cancer Research, 2016 Background: Overexpression of the transmembrane sialomucin podocalyxin, which is known to play a role in lumen formation during polarized epithelial morphogenesis, is an independent indicator of poor prognosis in a number of epithelial cancers, including those that arise in the breast.
Graves, Marcia L +7 more
openaire +3 more sources
Frontiers in Pharmacology, 2021 Modified Huangqi Chifeng decoction (MHCD) has been used to reduce proteinuria in immunoglobulin A nephropathy (IgAN) for many years. Previously, we have demonstrated its protective role in glomerular mesangial cells.
Meiying Chang +7 more
doaj +1 more source
Differential Expression Of Gap Junction mRNAs And Proteins In The Developing Murine Kidney And In Experimentally Induced Nephric Mesenchymes [PDF]
, 1992 The expression of three gap junction (GJ) proteins, alpha-1 (Cx43), beta-1 (Cx32), and beta-2 (Cx26), and their transcripts were examined during the ontogeny of the mouse and rat kidney. These proteins were expressed in two non-overlapping patterns.
Gilbert, Scott F. +6 more
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Systematic analysis of a novel human renal glomerulus-enriched gene expression dataset. [PDF]
, 2010 Glomerular diseases account for the majority of cases with chronic renal failure. Several genes have been identified with key relevance for glomerular function.
Anders, Hans-Joachim +8 more
core +5 more sources