Results 1 to 10 of about 7,104 (202)

Structural features and oligomeric nature of human podocin domain

Biochemistry and Biophysics Reports, 2020
Podocytes are crucial cells of the glomerular filtration unit and plays a vital role at the interface of the blood-urine barrier. Podocyte slit-diaphragm is a modified tight junction that facilitates size and charge-dependent permselectivity.
Sandeep K.N. Mulukala, Shivkumar S. Irukuvajjula, Krishan Kumar, Kanchan Garai, Pannuru Venkatesu, Ramakrishna Vadrevu, Anil K. Pasupulati   +6 more
doaj   +3 more sources

In vivo characterization of a podocyte-expressed short podocin isoform

BMC Nephrology, 2023
The most common genetic causes of steroid-resistant nephrotic syndrome (SRNS) are mutations in the NPHS2 gene, which encodes the cholesterol-binding, lipid-raft associated protein podocin. Mass spectrometry and cDNA sequencing revealed the existence of a
Linus Butt, David Unnersjö-Jess, Dervla Reilly, Robert Hahnfeldt, Markus M. Rinschen, Katarzyna Bozek, Bernhard Schermer, Thomas Benzing, Martin Höhne   +8 more
doaj   +5 more sources

Reflective versus predictive value of urinary podocin, nephrin, and their ratio in diabetic kidney disease: a 12-month retrospective cohort study [PDF]

Frontiers in Nephrology
IntroductionPodocyte injury plays a central role in the development of diabetic kidney disease (DKD). Urinary podocin, nephrin, and the podocin–nephrin ratio (PNR) have been proposed as early indicators of glomerular injury, but their prognostic value ...
Pringgodigdo Nugroho, Jeremia Siregar, Jeremia Siregar, Tri Juli Edi Tarigan, Kuntjoro Harimurti, Aida Lydia, Evy Yunihastuti, Pradana Soewondo, Hamzah Shatri   +8 more
doaj   +2 more sources

The MEC-2E isoform with a large C-terminal completely rescues the touch sensation defect of C. elegans [PDF]

Scientific Reports
Human podocin and C. elegans MEC-2 belong to the stomatin protein superfamily. They share 49% identity and 91% similarity both in the evolutionary conserved PHB domain (123-284 aa) and in the oligomerization region (273-351 aa).
Tália Magdolna Keszthelyi, Regina Légrádi, Dóra Pálya, Tímea Köles, Ágnes Regős, Dóra Karancsiné Menyhárd, Kálmán Tory   +6 more
doaj   +2 more sources

Longitudinal Study of the Vascular Glycocalyx and Urinary Podocyte Markers During Pregnancy [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background We aimed to assess the longitudinal changes of glycocalyx, a proteoglycan/glycoprotein layer that lines and protects endothelial cells in normotensive pregnancies (NPs); to correlate glycocalyx parameters with kidney injury markers (podocin ...
Oscar Garcia Valencia, Sonja Suvakov, Haitao Tu, Darah Dilmaghani, Natasa M. Milic, Tracey L. Weissgerber, Vladimir Dokic, Paul Gavrilovici, Jennet Hatamova, Jing Miao, Wendy M. White, Muthuvel Jayachandran, Karl Nath, Vesna D. Garovic   +13 more
doaj   +2 more sources

Modified Huangqi Chifeng decoction alleviates podocyte injury on rat with experimental membranous nephropathy [PDF]

Renal Failure
Objective This study aims to investigate the therapeutic effects of modified Huangqi Chifeng decoction (MHCD) on proteinuria in membranous nephropathy (MN) and its potential protective effects on podocytes.
Meiying Chang, Xiujie Shi, Bin Yang, Peng Li, Yifan Zhang, Qi Zhang, Yu Zhang   +6 more
doaj   +2 more sources

Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury in Diabetic Nephropathy Rats by Inhibiting Angpltl4/Integrin β3 in the Glomerulus [PDF]

Journal of Diabetes Research
In this study, we investigated the therapeutic effects and mechanisms of umbilical cord mesenchymal stem cells (UCMSCs) in diabetic nephropathy (DN) ZDF (FA/FA) rats.
Shiyuan Liu, Mingyao Meng, Chunkai Huang, Lijia He, Pu Wang, Zhe Tang, Xi Ran, Hui Gao, Yangfan Guo, Yan He, Jian Chen, Haiyan Hu, Shan He, Yiyi Zhao, Zongliu Hou, Lin Li, Wenhong Li, Wenju Wang, Xiaodan Wang   +18 more
doaj   +2 more sources

Peptide Charge Derivatization as a Tool for Early Detection of Preeclampsia by Mass Spectrometry—A Comparison with the ELISA Test

Molecules, 2021
Early detection of any preeclampsia biomarkers may lower the risk of mortality, both for a mother and a child. Our study focuses on techniques for preeclampsia biomarker identification by comparing the results of a method using liquid chromatography mass
Paulina Grocholska, Andrzej Konieczny, Zuzanna Kaźmierczak, Krystyna Dąbrowska, Karolina Panek-Laszczyńska, Marlena Kłak, Wojciech Witkiewicz, Zbigniew Szewczuk, Remigiusz Bąchor   +8 more
doaj   +1 more source

A novel domain regulating degradation of the glomerular slit diaphragm protein podocin in cell culture systems. [PDF]

PLoS ONE, 2013
Mutations in the gene NPHS2 are the most common cause of hereditary steroid-resistant nephrotic syndrome. Its gene product, the stomatin family member protein podocin represents a core component of the slit diaphragm, a unique structure that bridges the ...
Markus Gödel, Benjamin N Ostendorf, Jessica Baumer, Katrin Weber, Tobias B Huber   +4 more
doaj   +1 more source

Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease [PDF]

, 2013
Rho-family GTPases like RhoA and Rac-1 are potent regulators of cellular signaling that control gene expression, migration and inflammation. Activation of Rho-GTPases has been linked to podocyte dysfunction, a feature of chronic kidney diseases (CKD). We
Amann, Kerstin, Babelova, Andrea, Brandes, Ralf Peter Louis, Daniel, Christoph, Fork, Christian, Jansen, Felix, Jung, Oliver, Löhn, Matthias, Pavenstädt, Hermann, Plettenburg, Oliver, Ruetten, Hartmut, Sander, Kerstin, Schäfer, Liliana, Stark, Holger   +13 more
core   +8 more sources