Results 91 to 100 of about 7,104 (202)
Rare Functional Variants of Podocin (NPHS2) Promoter in Patients With Nephrotic Syndrome
Podocin (NPHS2) is a component of the glomerular slit-diaphragm, with major regulatory functions in renal permeability of proteins. Loss of podocin and decrease in resynthesis may influence the outcome of proteinuric renal disease such as segmental glomerulosclerosis (FSGS), and promoter functionality plays a key role in this process.
OLEGGINI R +13 more
openaire +5 more sources
Objective Podocytes are integral to the maintenance of the glomerular filtration barrier. Their injury results in proteinuria and disease progression in lupus nephritis (LN). Aberrant IgG glycosylation drives podocyte injury in LN and leads to cytoskeletal rearrangement, motility changes, and decreased nephrin production.
Rhea Bhargava +9 more
wiley +1 more source
There are controversies whether Minimal Change Disease (MCD) and Focal and Segmental Glomerulosclerosis (FSGS) are distinct glomerular lesions or different manifestations within the same spectrum of diseases.
Lívia Helena de Morais Pereira +10 more
doaj +1 more source
Parp1 protects against Aag-dependent alkylation-induced nephrotoxicity in a sex-dependent manner [PDF]
ephrotoxicity is a common toxic side-effect of chemotherapeutic alkylating agents. Although the base excision repair (BER) pathway is essential in repairing DNA alkylation damage, under certain conditions the initiation of BER produces toxic repair ...
Ashrafi +63 more
core +2 more sources
This review shows evidence from preclinical and clinical studies, supporting the therapeutic potential of polyphenols for diabetic kidney disease (DKD). This is due to their diverse bioactive properties and ability to intervene in intricate mechanisms of the disease.
Esienanwan E. Efiong +10 more
wiley +1 more source
Effect of Sirt1 on high glucose-induced exosome release from podocytes [PDF]
Objective To investigate the effect of nicotinamide adenine dinucleotide-dependent deacetylase 1 (Sirt1) on high glucose-induced exosome release from podocytes. Methods Immortalized mouse podocytes MPC5 were divided into six groups: normal glucose group (
DING Lin, ZHOU Yan, LIU Shanshan, LIU Nanchi, MA Ruixia
doaj +1 more source
Genetically Encoded Calcium Indicators: A New Tool in Renal Hypertension Research [PDF]
Hypertension is ranked as the third cause of disability-adjusted life-years. The percentage of the population suffering from hypertension will continue to increase over the next years.
Schleifenbaum, Johanna, Zhong, Cheng
core +1 more source
The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran +5 more
wiley +1 more source
Development of a Novel Diagnostic Test Using Podocyturia as a Biomarker for Detection of Kidney Damage [PDF]
Primary glomerular diseases are the most common cause of progressive chronic kidney disease (CKD) in dogs, a common and significant source of illness that often progresses to kidney failure.
Farooqi, Eesha
core +1 more source
Regeneration and Experimental Orthotopic Transplantation of a Bioengineered Kidney [PDF]
Over 100,000 individuals in the United States currently await kidney transplantation, while 400,000 individuals live with end-stage kidney disease requiring hemodialysis. The creation of a transplantable graft to permanently replace kidney function would
Gilpin, Sarah +5 more
core +1 more source

