Results 91 to 100 of about 7,139 (201)

Parp1 protects against Aag-dependent alkylation-induced nephrotoxicity in a sex-dependent manner [PDF]

, 2015
ephrotoxicity is a common toxic side-effect of chemotherapeutic alkylating agents. Although the base excision repair (BER) pathway is essential in repairing DNA alkylation damage, under certain conditions the initiation of BER produces toxic repair ...
Ashrafi, Bahn, Benzing, Botto, Bruno, Burckhardt, Caricchio, Elliot, Fukatsu, Garibotto, Goldschmeding, Golestaneh, Hellmark, Huang, Hurn, Karl, Kibbe, Koren, Koya, LeBlanc, Manabe, Matsumura, Matsumura, Moeckel, Nardulli, Nishinakagawa, Obrosova, Oh, Ortiz, Pacher, Padanilam, Padanilam, Padanilam, Patrick, Paz-Elizur, Pioli, Ponticelli, Povey, Price, Reckelhoff, Roth, Samson, Samson, Samson, Samson, Schwartz, Shankland, Silbiger, Silbiger, Skinner, Suszták, Suzuki, Szabo, Virág, Wagner, Warrens, Weber, Wiggins, Wilson, Wilson, Woolf, Yang, Zagonel, Zucker   +63 more
core   +2 more sources

Early Glomerular Filtration Defect and Severe Renal Disease in Podocin-Deficient Mice [PDF]

Molecular and Cellular Biology, 2004
Podocytes are specialized epithelial cells covering the basement membrane of the glomerulus in the kidney. The molecular mechanisms underlying the role of podocytes in glomerular filtration are still largely unknown. We generated podocin-deficient (Nphs2-/-) mice to investigate the function of podocin, a protein expressed at the insertion of the slit ...
Séverine, Roselli, Laurence, Heidet, Mireille, Sich, Anna, Henger, Matthias, Kretzler, Marie-Claire, Gubler, Corinne, Antignac   +6 more
openaire   +2 more sources

Aberrant Glycosylation of IgG in Children With Active Lupus Nephritis Alters Podocyte Metabolism and Causes Podocyte Injury

Arthritis &Rheumatology, Volume 77, Issue 10, Page 1421-1432, October 2025.
Objective Podocytes are integral to the maintenance of the glomerular filtration barrier. Their injury results in proteinuria and disease progression in lupus nephritis (LN). Aberrant IgG glycosylation drives podocyte injury in LN and leads to cytoskeletal rearrangement, motility changes, and decreased nephrin production.
Rhea Bhargava, Rohit Upadhyay, Cong Zhao, Prasad Katakam, Scott Wenderfer, Jing Chen, Hua He, Richard Cummings, Maria G. Tsokos, George C. Tsokos   +9 more
wiley   +1 more source

Specific Podocin Mutations Correlate with Age of Onset in Steroid-Resistant Nephrotic Syndrome [PDF]

Journal of the American Society of Nephrology, 2008
Mutations in the gene encoding podocin (NPHS2) cause autosomal recessive steroid-resistant nephrotic syndrome (SRNS). For addressing the possibility of a genotype-phenotype correlation between podocin mutations and age of onset, a worldwide cohort of 430 patients from 404 different families with SRNS were screened by direct sequencing.
Hinkes, Bernward, Vlangos, Christopher, Heeringa, Saskia, Mucha, Bettina, Gbadegesin, Rasheed, Liu, Jinhong, Hasselbacher, Katrin, Ozaltin, Fatih, Hildebrandt, Friedhelm   +8 more
openaire   +3 more sources

Multi‐Target Modulation of Polyphenols in Diabetic Kidney Disease Therapeutics: A Comprehensive Review

Food Science &Nutrition, Volume 13, Issue 10, October 2025.
This review shows evidence from preclinical and clinical studies, supporting the therapeutic potential of polyphenols for diabetic kidney disease (DKD). This is due to their diverse bioactive properties and ability to intervene in intricate mechanisms of the disease.
Esienanwan E. Efiong, Emmanuel Effa, Esther Peters, Ochuko L. Erukainure, Peter U. Amadi, Joshua Onyeka Ikebuiro, Sapna Sharma, Christoph Schmaderer, Kathrin Maedler, Emmy Tuenter, Harald Grallert   +10 more
wiley   +1 more source

Rosmarinic acid monotherapy is better than the combination of rosmarinic acid and telmisartan in preventing podocyte detachment and inhibiting the progression of diabetic nephropathy in rats

Biologics: Targets & Therapy, 2019
Nur Samsu,1 Setyawati Soeharto,2 Muhaimin Rifai,3 Achmad Rudijanto41Department of Internal Medicine, Division of Nephrology and Hypertension, Faculty of Medicine; 2Department of Pharmacology, Faculty of Medicine; 3Department of Biology, Faculty of ...
Samsu N, Soeharto S, Rifai M, Rudijanto A   +3 more
doaj  

Genetically Encoded Calcium Indicators: A New Tool in Renal Hypertension Research [PDF]

, 2019
Hypertension is ranked as the third cause of disability-adjusted life-years. The percentage of the population suffering from hypertension will continue to increase over the next years.
Schleifenbaum, Johanna, Zhong, Cheng
core   +1 more source

Rare Functional Variants of Podocin (NPHS2) Promoter in Patients With Nephrotic Syndrome

Gene Expression, 2006
Podocin (NPHS2) is a component of the glomerular slit-diaphragm, with major regulatory functions in renal permeability of proteins. Loss of podocin and decrease in resynthesis may influence the outcome of proteinuric renal disease such as segmental glomerulosclerosis (FSGS), and promoter functionality plays a key role in this process.
OLEGGINI R, BERTELLI R, DI DONATO A, DI DUCA M, CARIDI G, SANNA CHERCHI S, SCOLARI F, MURER L, ALLEGRI L, COPPO R, EMMA F, CAMUSSI, Giovanni, PERFUMO F, GHIGGERI GM   +13 more
openaire   +5 more sources

Development of a Novel Diagnostic Test Using Podocyturia as a Biomarker for Detection of Kidney Damage [PDF]

, 2013
Primary glomerular diseases are the most common cause of progressive chronic kidney disease (CKD) in dogs, a common and significant source of illness that often progresses to kidney failure.
Farooqi, Eesha
core   +1 more source

Regeneration and Experimental Orthotopic Transplantation of a Bioengineered Kidney [PDF]

, 2014
Over 100,000 individuals in the United States currently await kidney transplantation, while 400,000 individuals live with end-stage kidney disease requiring hemodialysis. The creation of a transplantable graft to permanently replace kidney function would
Gilpin, Sarah, Gonzalez, Gabriel, Guyette, Jacques, Ott, Harald C, Song, Jeremy J, Vacanti, Joseph P   +5 more
core   +1 more source