Results 31 to 40 of about 7,104 (202)

Antiproteinuric and Hyperkalemic Mechanisms Activated by Dual Versus Single Blockade of the RAS in Renovascular Hypertensive Rats

Frontiers in Physiology, 2021
This study aimed to investigate the antiproteinuric and hyperkalemic mechanisms activated by dual renin-angiotensin system (RAS) blockade in renovascular hypertensive rats (2-kidney 1-clip model [2K-1C]). Six weeks after clipping the left renal artery or
José Wilson N. Corrêa, José Wilson N. Corrêa, Karoline R. Boaro, Letícia B. Sene, Juliano Z. Polidoro, Thiago A. Salles, Flavia L. Martins, Lusiane M. Bendhack, Adriana C. C. Girardi   +8 more
doaj   +1 more source

Albumin uptake in human podocytes: a possible role for the cubilin-amnionless (CUBAM) complex [PDF]

, 2017
Albumin re-uptake is a receptor-mediated pathway located in renal proximal tubuli. There is increasing evidence of glomerular protein handling by podocytes, but little is known about the mechanism behind this process.
ANGLANI, FRANCA, CEOL, MONICA, DEL PRETE, DORELLA, GIANESELLO, LISA, PRIANTE, GIOVANNA, RADU, CLAUDIA-MARIA, Saleem, Moin A., SIMIONI, PAOLO, TERRIN, LILIANA   +8 more
core   +1 more source

Cloning of Rat Homologue of Podocin [PDF]

Journal of the American Society of Nephrology, 2003
Podocin is identified as a product of the gene mutated in a patient with autosomal recessive steroid-resistant nephrotic syndrome. Although podocin is reported to be located at the slit diaphragm area, the precise role of podocin for maintaining the barrier function of the slit diaphragm has not been clearly elucidated.
Hiroshi, Kawachi, Hiroko, Koike, Hidetake, Kurihara, Tatsuo, Sakai, Fujio, Shimizu   +4 more
openaire   +2 more sources

Biomarkers of Kidney Disease in Horses: A Review of the Current Literature

Animals, 2022
Creatinine only allows detection of kidney disease when 60 to 75% of the glomerular function is lost and is therefore not an ideal marker of disease. Additional biomarkers could be beneficial to assess kidney function and disease.
Gaby van Galen, Emil Olsen, Natalia Siwinska   +2 more
doaj   +1 more source

From Wild Vegetable to Renal Protector: The Therapeutic Potential of <i>Aralia elata</i> (Miq.) Seem. [PDF]

Food Sci Nutr
Aralia elata, a medicinal and edible wild vegetable, yields Araloside A (Ara A), a natural triterpenoid saponin. Experimental results show that Ara A, by mitigating oxidative stress and regulating ferroptosis‐related proteins via the SLC7A11/GSH/GPX4 pathway, can alleviate renal injury, reduce proteinuria, and delay glomerulosclerosis in model mice ...
Wu J, Liu Y, Xu Z, Tan H, Huang M, Jiang C, He W, Wei M, Du Z, Qiang S.   +9 more
europepmc   +2 more sources

NPHS2 mutation analysis shows genetic heterogeneityof steroid-resistant nephrotic syndrome and lowpost-transplant recurrence [PDF]

, 1926
NPHS2 mutation analysis shows genetic heterogeneity of steroid-resistant nephrotic syndrome and low post-transplant recurrence.BackgroundMutations of NPHS2 are causative in familial autosomal-recessive (AR) and sporadic steroid-resistant nephrotic ...
Weber, Stefanie, Gribouval, Olivier, Esquivel, Ernie L., Morinière, Vincent, Tête, Marie-Josèphe, Legendre, Christophe, Niaudet, Patrick, Antignac, Corinne   +7 more
core   +1 more source

Podocin mutations in sporadic focal-segmental glomerulosclerosis occurring in adulthood [PDF]

Kidney International, 2003
To the Editor: Podocin is a key component of the podocyte slit diaphragm. Mutations of podocin cause recessive steroid-resistant nephrotic syndrome that evolves to renal failure in early childhood [1]. They have also been found in children with sporadic nephrotic syndrome [2] and variable outcome including patients with steroid and cyclosporine ...
Caridi G, Bertelli R, SCOLARI, Francesco, Sanna Cherchi S, Di Duca M, Ghiggeri G.M.   +5 more
openaire   +3 more sources

C-terminal oligomerization of podocin mediates interallelic interactions

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018
Interallelic interactions of membrane proteins are not taken into account while evaluating the pathogenicity of sequence variants in autosomal recessive disorders. Podocin, a membrane-anchored component of the slit diaphragm, is encoded by NPHS2, the major gene mutated in hereditary podocytopathies.
Stráner, Pál, Balogh, Eszter, Gusztáv Schay, Christelle Arrondel, Mikó, Ágnes, Gerda L'Auné, Alexandre Benmerah, Perczel, András, Karancsiné Menyhárd, Dóra, Corinne Antignac, Géraldine Mollet, Tory, Kálmán   +11 more
openaire   +3 more sources

Podocin Localizes in the Kidney to the Slit Diaphragm Area [PDF]

The American Journal of Pathology, 2002
We recently cloned a novel gene, NPHS2, involved in autosomal recessive steroid-resistant nephrotic syndrome. This gene encodes a novel podocyte protein, podocin. Given its similarity with the stomatin family proteins, podocin is predicted to be an integral membrane protein with a single membrane domain forming a hairpin-like structure placing both N ...
Séverine, Roselli, Olivier, Gribouval, Nicolas, Boute, Mireille, Sich, France, Benessy, Tania, Attié, Marie-Claire, Gubler, Corinne, Antignac   +7 more
openaire   +2 more sources

Candesartan Mediated Amelioration of Cisplatin-Induced Testicular Damage Is Associated with Alterations in Expression Patterns of Nephrin and Podocin [PDF]

, 2014
Nephrin and podocin are known to be closely related to the pharmacological effects of angiotensin-II receptor blocker (ARB). The objectives of this study were to investigate the role of nephrin and podocin using cisplatin-induced testicular damage and to
Alings, M., Bouwels, L., Cuijpers, P., Habibovic, M., Herrman, J. P., Pedersen, Susanne S., Theuns, D., Valk, S., van der Voort, P.   +8 more
core   +5 more sources