Results 31 to 40 of about 7,139 (201)

NPHS2 mutation analysis shows genetic heterogeneityof steroid-resistant nephrotic syndrome and lowpost-transplant recurrence [PDF]

, 1926
NPHS2 mutation analysis shows genetic heterogeneity of steroid-resistant nephrotic syndrome and low post-transplant recurrence.BackgroundMutations of NPHS2 are causative in familial autosomal-recessive (AR) and sporadic steroid-resistant nephrotic ...
Weber, Stefanie, Gribouval, Olivier, Esquivel, Ernie L., Morinière, Vincent, Tête, Marie-Josèphe, Legendre, Christophe, Niaudet, Patrick, Antignac, Corinne   +7 more
core   +1 more source

Sorting Nexin 9 facilitates podocin endocytosis in the injured podocyte [PDF]

Scientific Reports, 2017
AbstractThe irreversibility of glomerulosclerotic changes depends on the degree of podocyte injury. We have previously demonstrated the endocytic translocation of podocin to the subcellular area in severely injured podocytes and found that this process is the primary disease trigger.
Yu Sasaki, Teruo Hidaka, Takashi Ueno, Miyuki Akiba-Takagi, Juan Alejandro Oliva Trejo, Takuto Seki, Yoshiko Nagai-Hosoe, Eriko Tanaka, Satoshi Horikoshi, Yasuhiko Tomino, Yusuke Suzuki, Katsuhiko Asanuma   +11 more
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A Compendium of Urinary Biomarkers Indicative of Glomerular Podocytopathy [PDF]

, 2013
It is well known that glomerular podocyte injury and loss are present in numerous nephropathies and that the pathophysiologic consecution of disease hinges upon the fate of the podocyte.
Pichler Sekulic, Simona, Sekulic, Miroslav   +1 more
core   +2 more sources

Cloning of Rat Homologue of Podocin [PDF]

Journal of the American Society of Nephrology, 2003
Podocin is identified as a product of the gene mutated in a patient with autosomal recessive steroid-resistant nephrotic syndrome. Although podocin is reported to be located at the slit diaphragm area, the precise role of podocin for maintaining the barrier function of the slit diaphragm has not been clearly elucidated.
Hiroshi, Kawachi, Hiroko, Koike, Hidetake, Kurihara, Tatsuo, Sakai, Fujio, Shimizu   +4 more
openaire   +2 more sources

Podocin mutations in sporadic focal-segmental glomerulosclerosis occurring in adulthood [PDF]

Kidney International, 2003
To the Editor: Podocin is a key component of the podocyte slit diaphragm. Mutations of podocin cause recessive steroid-resistant nephrotic syndrome that evolves to renal failure in early childhood [1]. They have also been found in children with sporadic nephrotic syndrome [2] and variable outcome including patients with steroid and cyclosporine ...
Caridi G, Bertelli R, SCOLARI, Francesco, Sanna Cherchi S, Di Duca M, Ghiggeri G.M.   +5 more
openaire   +3 more sources

Evaluation of Tryptic Podocin Peptide in Urine Sediment Using LC-MS-MRM Method as a Potential Biomarker of Glomerular Injury in Dogs with Clinical Signs of Renal and Cardiac Disorders

Molecules, 2019
The early asymptomatic stage of glomerular injury is a diagnostic challenge in the course of renal and extra-renal disease, e.g., heart insufficiency. It was found that podocin, a podocyte-specific protein present in the urine, may serve as a biomarker ...
Barbara Szczepankiewicz, Remigiusz Bąchor, Robert Pasławski, Natalia Siwińska, Urszula Pasławska, Andrzej Konieczny, Zbigniew Szewczuk   +6 more
doaj   +1 more source

Congenital nephrotic syndrome and recurrence of proteinuria after renal transplantation [PDF]

, 2014
Peer ...
Holmberg, Christer, Jalanko, Hannu
core   +1 more source

C-terminal oligomerization of podocin mediates interallelic interactions

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018
Interallelic interactions of membrane proteins are not taken into account while evaluating the pathogenicity of sequence variants in autosomal recessive disorders. Podocin, a membrane-anchored component of the slit diaphragm, is encoded by NPHS2, the major gene mutated in hereditary podocytopathies.
Stráner, Pál, Balogh, Eszter, Gusztáv Schay, Christelle Arrondel, Mikó, Ágnes, Gerda L'Auné, Alexandre Benmerah, Perczel, András, Karancsiné Menyhárd, Dóra, Corinne Antignac, Géraldine Mollet, Tory, Kálmán   +11 more
openaire   +3 more sources

Podocin Localizes in the Kidney to the Slit Diaphragm Area [PDF]

The American Journal of Pathology, 2002
We recently cloned a novel gene, NPHS2, involved in autosomal recessive steroid-resistant nephrotic syndrome. This gene encodes a novel podocyte protein, podocin. Given its similarity with the stomatin family proteins, podocin is predicted to be an integral membrane protein with a single membrane domain forming a hairpin-like structure placing both N ...
Séverine, Roselli, Olivier, Gribouval, Nicolas, Boute, Mireille, Sich, France, Benessy, Tania, Attié, Marie-Claire, Gubler, Corinne, Antignac   +7 more
openaire   +2 more sources

Antiproteinuric and Hyperkalemic Mechanisms Activated by Dual Versus Single Blockade of the RAS in Renovascular Hypertensive Rats

Frontiers in Physiology, 2021
This study aimed to investigate the antiproteinuric and hyperkalemic mechanisms activated by dual renin-angiotensin system (RAS) blockade in renovascular hypertensive rats (2-kidney 1-clip model [2K-1C]). Six weeks after clipping the left renal artery or
José Wilson N. Corrêa, José Wilson N. Corrêa, Karoline R. Boaro, Letícia B. Sene, Juliano Z. Polidoro, Thiago A. Salles, Flavia L. Martins, Lusiane M. Bendhack, Adriana C. C. Girardi   +8 more
doaj   +1 more source