Results 41 to 50 of about 7,104 (202)
Frontiers in Cell and Developmental Biology, 2023 Introduction: The unique architecture of glomerular podocytes is integral to kidney filtration. Interdigitating foot processes extend from the podocyte cell body, wrap around fenestrated capillaries, and form specialized junctional complexes termed slit ...
Gary F. Gerlach +4 more
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Congenital nephrotic syndrome and recurrence of proteinuria after renal transplantation [PDF]
, 2014 Peer ...
Holmberg, Christer, Jalanko, Hannu
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Podocin and Nephrotic Syndrome [PDF]
Journal of the American Society of Nephrology, 2004 Idiopathic nephrotic syndrome (INS) is the most frequent glomerular disease in childhood. Most of the children respond to corticosteroid therapy whereas 10% of them fail to respond to this treatment.
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Molecules, 2019 The early asymptomatic stage of glomerular injury is a diagnostic challenge in the course of renal and extra-renal disease, e.g., heart insufficiency. It was found that podocin, a podocyte-specific protein present in the urine, may serve as a biomarker ...
Barbara Szczepankiewicz +6 more
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Frontiers in Genetics, 2020 IntroductionPathogenic variants in different genes have been described as involved in the development of familial focal segmental glomerulosclerosis (FSGS).
Michelle T. P. Riguetti +6 more
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Endoplasmic reticulum–retained podocin mutants are massively degraded by the proteasome [PDF]
Journal of Biological Chemistry, 2018 Podocin is a key component of the slit diaphragm in the glomerular filtration barrier, and mutations in the podocin-encoding gene NPHS2 are a common cause of hereditary steroid-resistant nephrotic syndrome. A mutant allele encoding podocin with a p.R138Q amino acid substitution is the most frequent pathogenic variant in European and North American ...
Maria-Carmen, Serrano-Perez +8 more
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The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm. [PDF]
, 2008 The nephron is the basic structural and functional unit of the vertebrate kidney. It is composed of a glomerulus, the site of ultrafiltration, and a renal tubule, along which the filtrate is modified. Although widely regarded as a vertebrate adaptation, '
Bader, Augustinus +16 more
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Molecular Mechanisms of Proteinuria in Focal Segmental Glomerulosclerosis
Frontiers in Medicine, 2018 Focal segmental glomerulosclerosis (FSGS) is the most common primary glomerular disease resulting in end-stage renal disease in the USA and is increasing in prevalence worldwide.
Yumeng Wen, Sapna Shah, Kirk N. Campbell
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mRNA Expression of Podocyte Associated Proteins in Peripheral Blood Mononuclear Cells of Type 2 Diabetes Mellitus Patients with and without Nephropathy [PDF]
Journal of Krishna Institute of Medical Sciences University, 2020 Background: Diabetic nephropathy is the leading cause of End-Stage Renal Disease (ESRD) emerging in developed as well as developing countries, with the complicated pathogenesis.
Gouri M. Bhoite +4 more
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Containing anti-PLA2R IgG antibody induces podocyte injury in idiopathic membranous nephropathy
Renal Failure, 2023 Background Idiopathic membranous nephropathy is widely recognized as an autoimmune kidney disease that is accompanied by the discovery of several autoantibodies, and the antibody subclass in the circulation of patients with iMN is mainly IgG.
Ying Zhang +8 more
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