Results 41 to 50 of about 7,139 (201)
Albumin uptake in human podocytes: a possible role for the cubilin-amnionless (CUBAM) complex [PDF]
, 2017 Albumin re-uptake is a receptor-mediated pathway located in renal proximal tubuli. There is increasing evidence of glomerular protein handling by podocytes, but little is known about the mechanism behind this process.
ANGLANI, FRANCA +8 more
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Biomarkers of Kidney Disease in Horses: A Review of the Current Literature
Animals, 2022 Creatinine only allows detection of kidney disease when 60 to 75% of the glomerular function is lost and is therefore not an ideal marker of disease. Additional biomarkers could be beneficial to assess kidney function and disease.
Gaby van Galen +2 more
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Molecules, 2020 High complexity of cell and tissue proteomes limits the investigation of proteomic biomarkers. Therefore, the methods of enrichment of some chemical groups of peptides including thiopeptides are important tools that may facilitate the proteomic analysis ...
Remigiusz Bąchor +8 more
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Frontiers in Cell and Developmental Biology, 2023 Introduction: The unique architecture of glomerular podocytes is integral to kidney filtration. Interdigitating foot processes extend from the podocyte cell body, wrap around fenestrated capillaries, and form specialized junctional complexes termed slit ...
Gary F. Gerlach +4 more
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Podocin and Nephrotic Syndrome [PDF]
Journal of the American Society of Nephrology, 2004 Idiopathic nephrotic syndrome (INS) is the most frequent glomerular disease in childhood. Most of the children respond to corticosteroid therapy whereas 10% of them fail to respond to this treatment.
openaire +1 more source
The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm. [PDF]
, 2008 The nephron is the basic structural and functional unit of the vertebrate kidney. It is composed of a glomerulus, the site of ultrafiltration, and a renal tubule, along which the filtrate is modified. Although widely regarded as a vertebrate adaptation, '
Bader, Augustinus +16 more
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Endoplasmic reticulum–retained podocin mutants are massively degraded by the proteasome [PDF]
Journal of Biological Chemistry, 2018 Podocin is a key component of the slit diaphragm in the glomerular filtration barrier, and mutations in the podocin-encoding gene NPHS2 are a common cause of hereditary steroid-resistant nephrotic syndrome. A mutant allele encoding podocin with a p.R138Q amino acid substitution is the most frequent pathogenic variant in European and North American ...
Maria-Carmen, Serrano-Perez +8 more
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Characterization of novel glomerular proteins : role in physiology and disease [PDF]
, 2014 Glomerular damage accounts for the majority of chronic kidney disease cases, the prevalence of which is dramatically escalating worldwide, mainly due to increase in diabetes and associated nephropathy.
Andersson, Ann-Charlotte
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Molecular Mechanisms of Proteinuria in Focal Segmental Glomerulosclerosis
Frontiers in Medicine, 2018 Focal segmental glomerulosclerosis (FSGS) is the most common primary glomerular disease resulting in end-stage renal disease in the USA and is increasing in prevalence worldwide.
Yumeng Wen, Sapna Shah, Kirk N. Campbell
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Containing anti-PLA2R IgG antibody induces podocyte injury in idiopathic membranous nephropathy
Renal Failure, 2023 Background Idiopathic membranous nephropathy is widely recognized as an autoimmune kidney disease that is accompanied by the discovery of several autoantibodies, and the antibody subclass in the circulation of patients with iMN is mainly IgG.
Ying Zhang +8 more
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