Candesartan Mediated Amelioration of Cisplatin-Induced Testicular Damage Is Associated with Alterations in Expression Patterns of Nephrin and Podocin [PDF]
, 2014 Nephrin and podocin are known to be closely related to the pharmacological effects of angiotensin-II receptor blocker (ARB). The objectives of this study were to investigate the role of nephrin and podocin using cisplatin-induced testicular damage and to
Alings, M. +8 more
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mRNA Expression of Podocyte Associated Proteins in Peripheral Blood Mononuclear Cells of Type 2 Diabetes Mellitus Patients with and without Nephropathy [PDF]
Journal of Krishna Institute of Medical Sciences University, 2020 Background: Diabetic nephropathy is the leading cause of End-Stage Renal Disease (ESRD) emerging in developed as well as developing countries, with the complicated pathogenesis.
Gouri M. Bhoite +4 more
doaj
Genetic testing for nephrotic syndrome and FSGS in the era of next-generation sequencing [PDF]
, 2014 The haploid human genome is composed of three billion base pairs, about one percent of which consists of exonic regions, the coding sequence for functional proteins, also now known as the “exome”.
Barua, Moumita +2 more
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Frontiers in Genetics, 2020 IntroductionPathogenic variants in different genes have been described as involved in the development of familial focal segmental glomerulosclerosis (FSGS).
Michelle T. P. Riguetti +6 more
doaj +1 more source
NPHS2 (Podocin) Mutations in Nephrotic Syndrome. Clinical Spectrum and Fine Mechanisms [PDF]
Pediatric Research, 2005 Nephrotic syndrome (NS) is the most frequent cause of proteinuria in children and is emerging as a leading cause of uremia. Molecular studies in families with recessive NS have led to the discovery of specialized molecules endowed in podocytes that play a role in proteinuria.
Caridi, Gianluca +2 more
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CASE OF NON-SEVERE CONGENITAL NEPHROTIC SYNDROME
Педиатрическая фармакология, 2014 Nephrotic syndrome is a severe renal disease that may result in the end-stage renal failure despite the extent of proteinuria. Prognosis and tactics of therapy of nephrotic syndrome depend both on the morphological diagnosis and on the cause of the ...
I. S. Kostushina +6 more
doaj +1 more source
Mutational analysis in podocin-associated hereditary nephrotic syndrome in Polish patients: founder effect in the Kashubian population [PDF]
, 2013 Hereditary nephrotic syndrome is caused by mutations in a number of different genes, the most common being NPHS2. The aim of the study was to identify the spectrum of NPHS2 mutations in Polish patients with the disease.
Agnieszka Firszt-Adamczyk +20 more
core +2 more sources
European Journal of Cell BiologyNephrotic syndrome is frequently associated with pathogenic variants in NPHS2 (podocin), including the common and severe R138Q substitution. Using conditionally immortalized human podocytes expressing Myc-tagged podocin variants (G92C, V180M, R138Q ...
Pei-Chen Lu +6 more
doaj +1 more source
Characterization of a short isoform of the kidney protein podocin in human kidney [PDF]
, 2013 BACKGROUND: Steroid resistant nephrotic syndrome is a severe hereditary disease often caused by mutations in the NPHS2 gene. This gene encodes the lipid binding protein podocin which localizes to the slit diaphragm of podocytes and is essential for the ...
Barbara A Schutte +9 more
core +1 more source
Podocin-Green Fluorescence Protein Allows Visualization and Functional Analysis of Podocytes [PDF]
Journal of the American Society of Nephrology, 2011 Podocytes do not remain fully differentiated when cultured, and they are difficult to image in vivo, making the study of podocyte biology challenging. Zebrafish embryos are transparent and develop a single, midline, pronephric glomerulus accessible for imaging and systematic functional analysis.
Bing, He +4 more
openaire +2 more sources