Results 61 to 70 of about 7,104 (202)

The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes [PDF]

Human Molecular Genetics, 2016
The PHB-domain protein podocin maintains the renal filtration barrier and its mutation is an important cause of hereditary nephrotic syndrome. Podocin and its Caenorhabditis elegans orthologue MEC-2 have emerged as key components of mechanosensitive membrane protein signalling complexes.
Rinschen, Markus M., Bharill, Puneet, Wu, Xiongwu, Kohli, Priyanka, Reinert, Matthäus J., Kretz, Oliver, Saez, Isabel, Schermer, Bernhard, Höhne, Martin, Bartram, Malte P., Aravamudhan, Sriram, Brooks, Bernard R., Vilchez, David, Huber, Tobias B., Müller, Roman-Ulrich, Krüger, Marcus, Benzing, Thomas   +16 more
openaire   +5 more sources

Detection of podocyturia in patients with lupus nephritis [PDF]

, 2013
INTRODUCTION: The podocyturia has been detected in glomerular diseases, such as lupus nephritis (LN), in which proteinuria is an important manifestation, and its occurrence seems to be limited to the active phase of the disease.
Mansur, Juliana Busato, Mastroianni Kirsztajn, Gianna, Nishida, Sonia Kiyomi, Sabino, Amelia Rodrigues Pereira, Sass, Nelson, Teixeira, Vicente de Paulo Castro   +5 more
core   +3 more sources

Proteinuric Kidney Diseases: A Podocyte's Slit Diaphragm and Cytoskeleton Approach

Frontiers in Medicine, 2018
Proteinuric kidney diseases are a group of disorders with diverse pathological mechanisms associated with significant losses of protein in the urine.
Samuel Mon-Wei Yu, Pitchaphon Nissaisorakarn, Irma Husain, Belinda Jim, Belinda Jim   +4 more
doaj   +1 more source

Clinical and epidemiological assessment of steroid-resistant nephrotic syndrome associated with the NPHS2 R229Q variant [PDF]

, 2009
Mutations of NPHS2, encoding podocin, are the main cause of autosomal recessive steroid-resistant nephrotic syndrome (NS) presenting in childhood.
Machuca, Eduardo, Hummel, Aurélie, Nevo, Fabien, Dantal, Jacques, Martinez, Frank, Al-Sabban, Essam, Baudouin, Véronique, Abel, Laurent, Grünfeld, Jean-Pierre, Antignac, Corinne   +9 more
core   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Increasing urinary podocyte mRNA excretion and progressive podocyte loss in kidney contribute to the high risk of long-term renal disease caused by preterm birth

Scientific Reports, 2021
Podocyte abnormalities are common mechanism driving the progression of glomerular diseases, which account for most chronic kidney diseases (CKDs). However, the role of podocyte in the mechanism of high-risk long-term CKD caused by prematurity has not ...
Fangrui Ding, Qi Gao, Xiuying Tian, Jiali Mo, Jun Zheng   +4 more
doaj   +1 more source

IL‐15 Links Muscle–Kidney Crosstalk to Preserving Podocyte Mitochondrial Fusion and Attenuating Diabetic Nephropathy

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Objectives High glucose induces mitochondrial dysfunction in podocytes, contributing to the development of diabetic nephropathy (DN). There is increasing evidence that muscles play a protective role by secreting myokines into the kidneys. Here, we investigated how skeletal muscle influences podocyte health via muscle–kidney crosstalk.
Yin Li, Jialing Rao, Weiyan Lai, Yuxiang Sun, Hongchun Lin, Jun Zhang, Zengchun Ye, Zhaoyong Hu, Hui Peng   +8 more
wiley   +1 more source

VEGF-A165b protects against proteinuria in a mouse model with progressive depletion of all endogenous VEGF-A splice isoforms from the kidney [PDF]

, 2017
Chronic kidney disease (CKD) is strongly associated with a decrease in the expression of VEGF-A. However, little is known about the contribution of VEGF-A splice isoforms to kidney physiology and pathology.
Allison, Bates, Bevan, Cebe Suarez, Chen, Cross, Cumpanas, Eremina, Eremina, Go, Harper, Kawamura, Martini, Matsushita, Meguid El Nahas, Menini, Ollero, Oltean, Oltean, Oshikawa, Qiu, Salmon, Satchell, Schrijvers, Seong, Sivaskandarajah, Snyder, Veron, Zheng   +28 more
core   +4 more sources

Remodeling the Inflammatory Microenvironment: Nanomaterial‐Based Targeted Strategies for Systemic Lupus Erythematosus and Lupus Nephritis

Small Science, Volume 6, Issue 3, March 2026.
Current treatments for severe lupus nephritis are limited by side effects due to poor drug targeting. This review explores how smart nanomaterials—like liposomes and biomimetic carriers—can precisely deliver drugs to overactive immune cells and the kidneys. These nanotherapeutics enhance efficacy, reduce toxicity, and enable combination strategies. The
Cheng Zhou, Jiayi Li, Jian Zhang, Haifeng Wang, Haitao Lu, Shunlai Shang, Wenge Li   +6 more
wiley   +1 more source

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

Advanced Science, Volume 13, Issue 9, 13 February 2026.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li, Shimin Jiang, Qi Jin, Peng Qu, Yingjie Guo, Xushan Lan, Xinyu Li, Cuiting Sun, Sinan Ai, Xin Li, Weiliang Sun, Jing Guo, Wenge Li, Liang Peng, Lihong Liu   +14 more
wiley   +1 more source