Results 81 to 90 of about 7,139 (201)

Der Einfluss endogener und exogener Faktoren auf Podozyten und Nierenfunktion [PDF]

, 2018
Einleitung: Humane Podozyten (hPC) stellen hochdifferenzierte Zellen dar, die einen elementaren Bestandteil der renalen Filtrationsbarriere bilden. Ihre intensive Erforschung in vitro ist erst seit wenigen Jahren möglich.
Langer, Sebastian
core   +1 more source

Urinary podocyte-associated mRNA profile in various stages of diabetic nephropathy. [PDF]

PLoS ONE, 2011
BACKGROUND: Podocyte injury and subsequent excretion in urine play a crucial role in the pathogenesis and progression of diabetic nephropathy (DN). Quantification of messenger RNA (mRNA) expression in urinary sediment by real-time PCR is emerging as a ...
Min Zheng, Lin-Li Lv, Jie Ni, Hai-Feng Ni, Qing Li, Kun-Ling Ma, Bi-Cheng Liu   +6 more
doaj   +1 more source

A zebrafish model of conditional targeted podocyte ablation and regeneration [PDF]

, 2014
Podocytes are specialized cells that contribute critically to the normal structure and function of the glomerular filtration barrier. Their depletion plays an important role in the pathogenesis of glomerulosclerosis.
Davidson, Alan J, Huang, Hong Dong, Huang, Jianmin, Lu, Hua A J, Mckee, Mary, Xiang, Alice   +5 more
core   +1 more source

Rapamycin Ameliorates Proteinuria and Restores Nephrin and Podocin Expression in Experimental Membranous Nephropathy [PDF]

Clinical and Developmental Immunology, 2013
Objective. Recent studies have shown a beneficial effect of rapamycin in passive and active Heymann Nephritis (HN). However, the mechanisms underlying this beneficial effect have not been elucidated.Methods. Passive Heymann Nephritis (PHN) was induced by a single intravenous infusion of anti-Fx1 in 12 Sprague-Dawley male rats.
Stratakis, S., Stylianou, K., Petrakis, I., Mavroeidi, V., Poulidaki, R., Petra, C., Moisiadis, D., Stratigis, S., Vardaki, E., Nakopoulou, L., Daphnis, E.   +10 more
openaire   +4 more sources

Correlation study of podocyte injur y and kidney function in patients with acute kidney injur y

Journal of Acute Disease, 2016
Objective: To investigate the correlation between the podocyte injury indexes in urine such as nephrin, desmin, P-cadherin, podocin, podocalyxin and CD2-associated protein (CD2AP) and the kidney function in patients with acute kidney injury (AKI ...
You-Gang Feng, Bo Liang, Jun Liu, Ming-Dong Jiang, Hong-Jian Liu, Yi-Qiang Huang, Lu Xiao   +6 more
doaj   +1 more source

A Conditionally Immortalized Human Podocyte Cell Line Demonstrating Nephrin and Podocin Expression [PDF]

Journal of the American Society of Nephrology, 2002
Recent molecular insights have established the podocyte as a key component of the glomerular filtration barrier, and hence an important common pathway in proteinuric diseases. A conditionally immortalized human podocyte cell line has been developed by transfection with the temperature-sensitive SV40-T gene.
Chang, YX, Mathieson, PW, Ni, L, Mundel, P, Saleem, MA, O'Hare, MJ, Reiser, J, Coward, RJ, Inward, CD, Farren, T   +9 more
openaire   +3 more sources

槲皮素对糖尿病大鼠肾脏足细胞nephrin和podocin表达的影响

Zhongguo shiyan zhenduanxue, 2019
目的探讨槲皮素对糖尿病大鼠肾脏足细胞nephrin和podocin表达的影响。方法采用腹腔注射链脲佐菌素(STZ)方法构建糖尿病大鼠模型,分为正常对照组、糖尿病模型组、槲皮素给药组。12周后测定肾脏指数、血肌酐、尿素水平及24h尿中总蛋白、白蛋白、肌酐、尿素水平;Western blot方法检测肾皮质nephrin和podocin的蛋白表达。结果槲皮素给药组肾脏指数、血肌酐和尿素水平低于糖尿病模型组;槲皮素给药组尿中总蛋白、白蛋白水平明显低于糖尿病组,尿中肌酐、尿素水平高于糖尿病组 ...
靳英丽, 屈智慧, 杨盼盼, 袁渤雨, 陈丽波   +4 more
doaj  

Centrosome amplification disrupts renal development and causes cystogenesis [PDF]

, 2018
International ...
Amanda Knoten, Arquint, Astrinidis, Battini, Bettencourt-Dias, Bhaskar, Boehlke, Boletta, Brito, Brown, Burtey, Chang-Panesso, Chen, Chi, Coelho, Cosenza, Davenport, Dere, Distefano, Fisher, Ganem, Godinho, Godinho, Godinho, Goto, Habedanck, Hartman, Hendry, Hoshi, Jain, Jain, Janssen, Jinzhi Wang, Jonassen, Keefe Davis, Kobayashi, Krämer, Kulukian, Kyuhwan Shim, Lai Kuan Dionne, Levine, Lin, Ma, Mahjoub, Majumdar, Marthiens, Marthiens, Masato Hoshi, Masyuk, Moe R. Mahjoub, Mugford, Mundlos, Nano, Nigg, Nigg, Ogden, Patel, Quintyne, Renata Basto, Roselli, Saifudeen, Saifudeen, Sanjay Jain, Schmidt-Ott, Serçin, Shao, Sharma, Shillingford, Silkworth, Sillibourne, Simons, Srivastava, Takakura, Tammachote, Tao Cheng, Veronique Marthiens, Vitre, Werner, Yoder, Zhao   +79 more
core   +8 more sources

Inhibition of AMPKα Pathway by Podocyte GOLM1 Exacerbates Diabetic Nephrology in Mice

Advanced Science, Volume 12, Issue 37, October 6, 2025.
Podocyte Golgi membrane protein 1 interacts with epidermal growth factor receptor to inhibit peroxisome proliferator activated receptor γ, and then inactivates adenosine monophosphate activated protein kinase α pathway, which facilitates diabetes‐related inflammation, oxidative damage, apoptosis, and renal dysfunction.
Peng Xu, Kaiqiang Li, Huasong Liu, Aibo Xu, Zhewei Zhang, Yimin Yang, Xiaobo Lai, Ke Hao, Kui Fang, Zeyu Lai, Xiping Ou, Yuqun Cai, Zhen Wang, Keda Lu, Wanli Jiang   +14 more
wiley   +1 more source

A Review of Focal Segmental Glomerulosclerosis Classification With a Focus on Genetic Associations

Kidney Medicine
Focal segmental glomerulosclerosis (FSGS) defines a distinct histologic pattern observed in kidney tissue that is linked to several distinct underlying causes, all converging on the common factor of podocyte injury.
Marco Bonilla, Orhan Efe, Haresh Selvaskandan, Edgar V. Lerma, Nasim Wiegley   +4 more
doaj   +1 more source