Results 81 to 90 of about 7,104 (202)

A Conditionally Immortalized Human Podocyte Cell Line Demonstrating Nephrin and Podocin Expression [PDF]

Journal of the American Society of Nephrology, 2002
Recent molecular insights have established the podocyte as a key component of the glomerular filtration barrier, and hence an important common pathway in proteinuric diseases. A conditionally immortalized human podocyte cell line has been developed by transfection with the temperature-sensitive SV40-T gene.
Chang, YX, Mathieson, PW, Ni, L, Mundel, P, Saleem, MA, O'Hare, MJ, Reiser, J, Coward, RJ, Inward, CD, Farren, T   +9 more
openaire   +3 more sources

Correlation study of podocyte injur y and kidney function in patients with acute kidney injur y

Journal of Acute Disease, 2016
Objective: To investigate the correlation between the podocyte injury indexes in urine such as nephrin, desmin, P-cadherin, podocin, podocalyxin and CD2-associated protein (CD2AP) and the kidney function in patients with acute kidney injury (AKI ...
You-Gang Feng, Bo Liang, Jun Liu, Ming-Dong Jiang, Hong-Jian Liu, Yi-Qiang Huang, Lu Xiao   +6 more
doaj   +1 more source

Urinary podocyte-associated mRNA profile in various stages of diabetic nephropathy. [PDF]

PLoS ONE, 2011
BACKGROUND: Podocyte injury and subsequent excretion in urine play a crucial role in the pathogenesis and progression of diabetic nephropathy (DN). Quantification of messenger RNA (mRNA) expression in urinary sediment by real-time PCR is emerging as a ...
Min Zheng, Lin-Li Lv, Jie Ni, Hai-Feng Ni, Qing Li, Kun-Ling Ma, Bi-Cheng Liu   +6 more
doaj   +1 more source

Der Einfluss endogener und exogener Faktoren auf Podozyten und Nierenfunktion [PDF]

, 2018
Einleitung: Humane Podozyten (hPC) stellen hochdifferenzierte Zellen dar, die einen elementaren Bestandteil der renalen Filtrationsbarriere bilden. Ihre intensive Erforschung in vitro ist erst seit wenigen Jahren möglich.
Langer, Sebastian
core   +1 more source

Early Glomerular Filtration Defect and Severe Renal Disease in Podocin-Deficient Mice [PDF]

Molecular and Cellular Biology, 2004
Podocytes are specialized epithelial cells covering the basement membrane of the glomerulus in the kidney. The molecular mechanisms underlying the role of podocytes in glomerular filtration are still largely unknown. We generated podocin-deficient (Nphs2-/-) mice to investigate the function of podocin, a protein expressed at the insertion of the slit ...
Séverine, Roselli, Laurence, Heidet, Mireille, Sich, Anna, Henger, Matthias, Kretzler, Marie-Claire, Gubler, Corinne, Antignac   +6 more
openaire   +2 more sources

Rosmarinic acid monotherapy is better than the combination of rosmarinic acid and telmisartan in preventing podocyte detachment and inhibiting the progression of diabetic nephropathy in rats

Biologics: Targets & Therapy, 2019
Nur Samsu,1 Setyawati Soeharto,2 Muhaimin Rifai,3 Achmad Rudijanto41Department of Internal Medicine, Division of Nephrology and Hypertension, Faculty of Medicine; 2Department of Pharmacology, Faculty of Medicine; 3Department of Biology, Faculty of ...
Samsu N, Soeharto S, Rifai M, Rudijanto A   +3 more
doaj  

Centrosome amplification disrupts renal development and causes cystogenesis [PDF]

, 2018
International ...
Amanda Knoten, Arquint, Astrinidis, Battini, Bettencourt-Dias, Bhaskar, Boehlke, Boletta, Brito, Brown, Burtey, Chang-Panesso, Chen, Chi, Coelho, Cosenza, Davenport, Dere, Distefano, Fisher, Ganem, Godinho, Godinho, Godinho, Goto, Habedanck, Hartman, Hendry, Hoshi, Jain, Jain, Janssen, Jinzhi Wang, Jonassen, Keefe Davis, Kobayashi, Krämer, Kulukian, Kyuhwan Shim, Lai Kuan Dionne, Levine, Lin, Ma, Mahjoub, Majumdar, Marthiens, Marthiens, Masato Hoshi, Masyuk, Moe R. Mahjoub, Mugford, Mundlos, Nano, Nigg, Nigg, Ogden, Patel, Quintyne, Renata Basto, Roselli, Saifudeen, Saifudeen, Sanjay Jain, Schmidt-Ott, Serçin, Shao, Sharma, Shillingford, Silkworth, Sillibourne, Simons, Srivastava, Takakura, Tammachote, Tao Cheng, Veronique Marthiens, Vitre, Werner, Yoder, Zhao   +79 more
core   +8 more sources

Specific Podocin Mutations Correlate with Age of Onset in Steroid-Resistant Nephrotic Syndrome [PDF]

Journal of the American Society of Nephrology, 2008
Mutations in the gene encoding podocin (NPHS2) cause autosomal recessive steroid-resistant nephrotic syndrome (SRNS). For addressing the possibility of a genotype-phenotype correlation between podocin mutations and age of onset, a worldwide cohort of 430 patients from 404 different families with SRNS were screened by direct sequencing.
Hinkes, Bernward, Vlangos, Christopher, Heeringa, Saskia, Mucha, Bettina, Gbadegesin, Rasheed, Liu, Jinhong, Hasselbacher, Katrin, Ozaltin, Fatih, Hildebrandt, Friedhelm   +8 more
openaire   +3 more sources

Inhibition of AMPKα Pathway by Podocyte GOLM1 Exacerbates Diabetic Nephrology in Mice

Advanced Science, Volume 12, Issue 37, October 6, 2025.
Podocyte Golgi membrane protein 1 interacts with epidermal growth factor receptor to inhibit peroxisome proliferator activated receptor γ, and then inactivates adenosine monophosphate activated protein kinase α pathway, which facilitates diabetes‐related inflammation, oxidative damage, apoptosis, and renal dysfunction.
Peng Xu, Kaiqiang Li, Huasong Liu, Aibo Xu, Zhewei Zhang, Yimin Yang, Xiaobo Lai, Ke Hao, Kui Fang, Zeyu Lai, Xiping Ou, Yuqun Cai, Zhen Wang, Keda Lu, Wanli Jiang   +14 more
wiley   +1 more source

High glucose induces podocyte injury via enhanced (pro)renin receptor-Wnt-β-catenin-snail signaling pathway. [PDF]

PLoS ONE, 2014
(Pro)renin receptor (PRR) expression is upregulated in diabetes. We hypothesized that PRR contributes to podocyte injury via activation of Wnt-β-catenin-snail signaling pathway. Mouse podocytes were cultured in normal (5 mM) or high (25 mM) D-glucose for
Caixia Li, Helmy M Siragy
doaj   +1 more source