Results 1 to 10 of about 28,951 (302)
MicroRNAs in Podocyte Injury in Diabetic Nephropathy [PDF]
Frontiers in Genetics, 2020 Diabetic nephropathy is one of the major complications of diabetes mellitus and is the leading cause of end-stage renal disease worldwide. Podocyte injury contributes to the development of diabetic nephropathy.
Hiroki Ishii +7 more
doaj +4 more sources
Podocyte Injury Can Be Catching [PDF]
Journal of the American Society of Nephrology, 2011 Podocyte loss is a central mediator of glomerular sclerosis. Because podocytes are terminally differentiated cells that lack the potential to proliferate, they are particularly vulnerable to attrition in response to critical levels of cell stress, leading to detachment, necrosis, or apoptosis ...
Vivette D. D’Agati
openalex +2 more sources
The Protective Role of KANK1 in Podocyte Injury. [PDF]
Int J Mol SciApproximately 30% of steroid-resistant nephrotic syndromes are attributed to monogenic disorders that involve 27 genes. Mutations in KANK family members have also been linked to nephrotic syndrome; however, the precise mechanism remains elusive. To investigate this, podocyte-specific Kank1 knockout mice were generated to examine phenotypic changes.
Oda K +15 more
europepmc +3 more sources
Mechanisms of podocyte injury and implications for diabetic nephropathy
Clinical Science, 2022 Abstract Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies, including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and diabetic nephropathy (DN). Moreover, albuminuria is an important feature of all chronic kidney diseases (CKDs). Podocytes play a key role in maintaining the
Federica Barutta +2 more
exaly +3 more sources
The podocyte's response to injury: Role in proteinuria and glomerulosclerosis [PDF]
Kidney International, 2006 The terminally differentiated podocyte, also called glomerular visceral epithelial cell, are highly specialized cells. They function as a critical size and charge barrier to prevent proteinuria. Podocytes are injured in diabetic and non-diabetic renal diseases.
exaly +4 more sources
Urinary biomarkers associated with podocyte injury in lupus nephritis [PDF]
Frontiers in PharmacologyThe most prevalent and devastating form of organ damage in systemic lupus erythematosus (SLE) is lupus nephritis (LN). LN is characterized by glomerular injury, inflammation, cell proliferation, and necrosis, leading to podocyte injury and tubular ...
Zhiying Guo +5 more
doaj +2 more sources
Normal and Dysregulated Sphingolipid Metabolism: Contributions to Podocyte Injury and Beyond [PDF]
CellsPodocyte health is vital for maintaining proper glomerular filtration in the kidney. Interdigitating foot processes from podocytes form slit diaphragms which regulate the filtration of molecules through size and charge selectivity. The abundance of lipid
Matthew Tolerico +2 more
doaj +2 more sources
DOT1L protects against podocyte injury in diabetic kidney disease through phospholipase C-like 1 [PDF]
Cell Communication and SignalingBackground Podocyte injury causes proteinuria and accelerates glomerular sclerosis during diabetic kidney disease (DKD). Disruptor of telomeric silencing 1-like (DOT1L), an evolutionarily conserved histone methyltransferase, has been reported in ...
Yepeng Hu +18 more
doaj +2 more sources
Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease [PDF]
, 2013 Rho-family GTPases like RhoA and Rac-1 are potent regulators of cellular signaling that control gene expression, migration and inflammation. Activation of Rho-GTPases has been linked to podocyte dysfunction, a feature of chronic kidney diseases (CKD). We
Amann, Kerstin +13 more
core +18 more sources
Breviscapine alleviates podocyte injury by inhibiting NF-κB/NLRP3-mediated pyroptosis in diabetic nephropathy [PDF]
PeerJ, 2023 Podocyte injury is a critical factor in the pathogenesis of diabeticnephropathy (DN). Emerging evidence has demonstrated that breviscapine (Bre) exerts a renoprotective effect on diabetic rats.
Linlin Sun +4 more
doaj +2 more sources