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PARP12 is required for mitochondrial function maintenance in thermogenic adipocytes
Adipocyte, 2022 PARP12 is a member of poly-ADP-ribosyl polymerase (PARPs), which has been characterized for its antiviral function. Yet its physiological implication in adipocytes remains unknown.
Fan Hu +9 more
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Novel modulators of poly(ADP-ribose) polymerase [PDF]
Trends in Pharmacological Sciences, 2006 The nuclear enzyme poly(ADP-ribose) polymerase (PARP)-1 has an important role in regulating cell death and cellular responses to DNA repair. Pharmacological inhibitors of PARP have entered clinical testing as cytoprotective agents in cardiovascular diseases and as adjunct antitumor therapeutics.
Csaba, Szabo +2 more
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The Dichotomy of the Poly(ADP-Ribose) Polymerase-Like Thermozyme from Sulfolobus solfataricus
Challenges, 2018 The first evidence of an ADP-ribosylating activity in Archaea was obtained in Sulfolobus solfataricus(strain MT-4) where a poly(ADP-ribose) polymerase (PARP)-like thermoprotein, defined with the acronymous PARPSso, was found.
Maria Rosaria Faraone Mennella
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Nature Communications, 2018 Poly(ADP-ribose) polymerases (PARPs) catalyse ADP-ribose posttranslational modifications using NAD+ as a substrate. Here, the authors present the crystal structure of PARP-1 bound to the non-hydrolyzable NAD+ analog BAD and provide insights into the ...
Marie-France Langelier +4 more
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VERO cells harbor a poly-ADP-ribose belt partnering their epithelial adhesion belt [PDF]
PeerJ, 2014 Poly-ADP-ribose (PAR) is a polymer of up to 400 ADP-ribose units synthesized by poly-ADP-ribose-polymerases (PARPs) and degraded by poly-ADP-ribose-glycohydrolase (PARG).
Laura Lafon-Hughes +3 more
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Poly(ADP‐Ribose) Polymerase in Plant Nuclei [PDF]
European Journal of Biochemistry, 1994 We show that poly(ADP‐ribose) polymerase is present in maize, pea and wheat nuclei. We have identified the enzyme product as poly(ADP‐ribose) by purification and electrophoresis on a DNA sequencing gel. This reveals a polymer ladder consisting of up to 45 residues. The polymer product from maize, after digestion with snake venom phosphodiesterase, gave
Y M, Chen, S, Shall, M, O'Farrell
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PARP1 (poly(ADP-ribose) polymerase 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2020 PARP1 (poly(ADP-ribose) polymerase 1) is a nuclear protein involved in the regulation of various biological processes including apoptosis, DNA repair for the maintenance of genome integrity, epigenetic marking of chromatin, assembly of higher-order chromatin structures, transcriptional activation, differentiation, proliferation, and cell cycle ...
Tunçer, Sinem, Kavak, Kubra
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Nature Communications, 2017 Tankyrase 1 and 2 are poly(ADP-ribose) polymerases that mark proteins for degradation, but there is a current lack of knowledge about their distinct functions and substrates.
Amit Bhardwaj +3 more
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The Viral Macrodomain Counters Host Antiviral ADP-Ribosylation
Viruses, 2020 Macrodomains, enzymes that remove ADP-ribose from proteins, are encoded by several families of RNA viruses and have recently been shown to counter innate immune responses to virus infection.
Yousef M. O. Alhammad, Anthony R. Fehr
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