Results 1 to 10 of about 9,305 (142)

Polyamine Oxidase-Generated Reactive Oxygen Species in Plant Development and Adaptation: The Polyamine Oxidase—NADPH Oxidase Nexus [PDF]

Antioxidants, 2022
Metabolism and regulation of cellular polyamine levels are crucial for living cells to maintain their homeostasis and function. Polyamine oxidases (PAOs) terminally catabolize polyamines or catalyse the back-conversion reactions when spermine is ...
Péter Benkő, Katalin Gémes, Attila Fehér   +2 more
doaj   +5 more sources

Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Fourteen polyamine analogues, asymmetric or symmetric substituted spermine (1–9) or methoctramine (10–14) analogues, were evaluated as potential inhibitors or substrates of two enzymes of the polyamine catabolic pathway, spermine oxidase (SMOX) and ...
Maria Luisa Di Paolo, Manuela Cervelli, Paolo Mariottini, Alessia Leonetti, Fabio Polticelli, Michela Rosini, Andrea Milelli, Filippo Basagni, Rina Venerando, Enzo Agostinelli, Anna Minarini   +10 more
doaj   +7 more sources

Targeting Polyamine Oxidase to Prevent Excitotoxicity-Induced Retinal Neurodegeneration [PDF]

Frontiers in Neuroscience, 2019
Dysfunction of retinal neurons is a major cause of vision impairment in blinding diseases that affect children and adults worldwide. Cellular damage resulting from polyamine catabolism has been demonstrated to be a major player in many neurodegenerative ...
Prahalathan Pichavaram, Prahalathan Pichavaram, Chithra Devi Palani, Chithra Devi Palani, Chithra Devi Palani, Chintan Patel, Chintan Patel, Zhimin Xu, Zhimin Xu, Esraa Shosha, Esraa Shosha, Abdelrahman Y. Fouda, Abdelrahman Y. Fouda, Ruth B. Caldwell, Ruth B. Caldwell, Ruth B. Caldwell, Subhadra Priya Narayanan, Subhadra Priya Narayanan, Subhadra Priya Narayanan, Subhadra Priya Narayanan, Subhadra Priya Narayanan   +20 more
doaj   +2 more sources

Defining novel plant polyamine oxidase subfamilies through molecular modeling and sequence analysis [PDF]

BMC Evolutionary Biology, 2019
Background The polyamine oxidases (PAOs) catabolize the oxidative deamination of the polyamines (PAs) spermine (Spm) and spermidine (Spd). Most of the phylogenetic studies performed to analyze the plant PAO family took into account only a limited number ...
Cesar Daniel Bordenave, Carolina Granados Mendoza, Juan Francisco Jiménez Bremont, Andrés Gárriz, Andrés Alberto Rodríguez   +4 more
doaj   +2 more sources

Polyamine metabolism as a regulator of cellular and organismal aging [PDF]

Amino Acids
Polyamines - putrescine, spermidine, and spermine - are ubiquitous cationic molecules that are essential for cellular proliferation and homeostasis.
Takeshi Uemura, Jun Takayama, Akihiro Oguro, Yusuke Terui   +3 more
doaj   +2 more sources

Amino acid decarboxylation preserves Salmonella fitness during phagocyte-derived oxidative stress [PDF]

mBio
Successful establishment of infection by non-typhoidal Salmonella depends upon its ability to resist the antimicrobial defenses of the host innate immune response. To withstand the membrane depolarization that potentiates the killing activity of reactive
Alyssa Margolis, Lin Liu, Ju-Sim Kim, Steffen Porwollik, Michael McClelland, Andrés Vázquez-Torres   +5 more
doaj   +2 more sources

Improvment of cold tolerance of chickpea through heavy polyamines catabolism and ethylene phytohormone [PDF]

مجله بیوتکنولوژی کشاورزی, 2023
Objective The current study was undertaken to investigate if there is a relationship between metabolism of ethylene and heavy polyamines (PAs) under cold stress in cold-tolerant and cold-sensitive chickpea (Cicer arietinum L.) genotypes.
Saeed Amini, Reza Maali Amiri, Hasan Zeinali   +2 more
doaj   +1 more source

Investigation of The Roles of Hydrogen Peroxide and NADPH Oxidase in The Regulation of Polyamine Metabolism in Maize Plants under Drought Stress Conditions

Journal of Agricultural Sciences, 2022
The relationship between hydrogen peroxide and the metabolism of polyamines and the role of NADPH oxidase (NOX) in that relationship under drought conditions remains unclear.
Aykut Sağlam, Mehmet Demiralay, Fuat Yetişsin, Asım Kadıoğlu   +3 more
doaj   +1 more source

Changes in Whole Blood Polyamine Levels and Their Background in Age-Related Diseases and Healthy Longevity

Biomedicines, 2023
The relationship between polyamines and healthy longevity has received much attention in recent years. However, conducting research without understanding the properties of polyamines can lead to unexpected pitfalls.
Kuniyasu Soda
doaj   +1 more source

Amine oxidases as important agents of pathological processes of rhabdomyolysis in rats [PDF]

The Ukrainian Biochemical Journal, 2016
In this study we have tested an idea on the important role of amine oxidases (semicarbazide-sensitive amine oxidase, diamine oxidase, polyamine oxidase) as an additional source of oxidative/carbonyl stress under glycerol-induced rhabdomyolysis, since the
O. O. Gudkova, N. V. Latyshko, S. G. Shandrenko   +2 more
doaj   +1 more source