Results 61 to 70 of about 55,739 (236)

Transcriptome Analysis Identifies a Gene Cluster for the Biosynthesis of Biruloquinone, a Rare Phenanthraquinone, in a Lichen-Forming Fungus Cladonia macilenta

Journal of Fungi, 2021
Lichens are prolific producers of natural products of polyketide origin. We previously described a culture of lichen-forming fungus (LFF) Cladonia macilenta that produces biruloquinone, a purple pigment that is a phenanthraquinone rarely found in nature.
Wonyong Kim, Min-Hye Jeong, Sung-Hwan Yun, Jae-Seoun Hur   +3 more
doaj   +1 more source

Phylogenomic analysis of natural products biosynthetic gene clusters allows discovery of arseno-organic metabolites in model streptomycetes [PDF]

, 2016
We are indebted with Marnix Medema, Paul Straight and Sean Rovito, for useful discussions and critical reading of the manuscript, as well as with Alicia Chagolla and Yolanda Rodriguez of the MS Service of Unidad Irapuato, Cinvestav, and Araceli Fernandez
Barona-Gomez, Francisco, Cruz-Morales, Pablo, Feldmann, Jorg, Kopp, Johannes Florian, Martinez-Guerrero, Christian, Mojica, Nelly Selem, Ramos-Aboites, Hilda, Yáñez-Guerra, Luis Alfonso   +7 more
core   +1 more source

A Genomic Catalog of Migratory Microbiomes from Wild Birds across China's Habitats

Advanced Science, EarlyView.
ABSTRACT Migratory birds play an important role in the spread of antimicrobial resistance (AMR); however, gaps in surveillance data from vital regions along migratory flyways across China limit the detection of emergent threats. Here, we assembled 340 metagenomes from 52 bird species covering 11 provincial administrative districts in China, presenting ...
Yanan Wang, Heqi Wu, Mengqi Qu, Chunge Zhang, Ziqian Xu, Yuhang Pei, Chaochao Zhao, Jiangtao Wang, Sufang Ma, Na Lyu, Xuebin Xu, Yuhai Bi, Baoli Zhu, George F. Gao   +13 more
wiley   +1 more source

Polyketide synthesis in vitro on a modular polyketide synthase

Chemistry & Biology, 1995
The 6-deoxyerythronolide B synthase (DEBS) of Saccharopolyspora erythraea, which synthesizes the aglycone core of the antibiotic erythromycin A, contains some 30 active sites distributed between three multienzyme polypeptides (designated DEBS1-3). This complexity has hitherto frustrated mechanistic analysis of such enzymes.
Wiesmann, Kirsten E.H., Cortés, Jesus, Brown, Murray J.B., Cutter, Annabel L., Staunton, James, Leadlay, Peter F.   +5 more
openaire   +2 more sources

Diversity oriented biosynthesis via accelerated evolution of modular gene clusters. [PDF]

, 2017
Erythromycin, avermectin and rapamycin are clinically useful polyketide natural products produced on modular polyketide synthase multienzymes by an assembly-line process in which each module of enzymes in turn specifies attachment of a particular ...
Alanine, Alexander, Alt, Silke, Carter, Guy T, Chao, Suzan Keen, Coates, Nigel J, Graziani, Edmund I, Gregory, Matthew A, Heine, Daniel, Higginbotham, Sarah J, Hold, Adam, Kendrew, Steve G, Koehn, Frank E, Leadlay, Peter F, Martin, Christine J, McDonald, Leonard, Moss, Steven J, Norville, Isobel H, Nur-E-Alam, Mohammad, Overvoorde, Lois, Pogwizd, Joanna, Radzom, Markus, Ratni, Hasane, Rodríguez Sarmiento, Rosa María, Rudder, Steven, Samborskyy, Markiyan, Sarkar-Tyson, Mitali, Sheehan, Lesley S, Stanley-Smith, Anna E, Steward, Lucinda, Warneck, Tony, Wilkinson, Barrie, Wlodek, Aleksandra   +31 more
core   +2 more sources

Quantification of Fusarium graminearum and Fusarium culmorum by real-time PCR system and zearalenone assessment in maize [PDF]

, 2012
Zearalenone (ZEA) is a mycotoxin produced by some species of Fusarium, especially by Fusarium graminearum and F. culmorum. ZEA induces hyperoestrogenic responses in mammals and can result in reproductive disorders in farm animals. In the present study, a
Atoui, Ali, El Khoury, André, Kallassy, Mireille, Lebrihi, Ahmed   +3 more
core   +1 more source

Evolution by Pervasive Gene Fusion in Antibiotic Resistance and Antibiotic Synthesizing Genes

Computation, 2015
Phylogenetic (tree-based) approaches to understanding evolutionary history are unable to incorporate convergent evolutionary events where two genes merge into one.
Orla Coleman, Ruth Hogan, Nicole McGoldrick, Niamh Rudden, James O. McInerney   +4 more
doaj   +1 more source

Identification of candidate genes affecting Delta9-tetrahydrocannabinol biosynthesis in Cannabis sativa. [PDF]

, 2009
RNA isolated from the glands of a Delta(9)-tetrahydrocannabinolic acid (THCA)-producing strain of Cannabis sativa was used to generate a cDNA library containing over 100 000 expressed sequence tags (ESTs).
Dixon, Richard A, Gang, David R, He, Ji, Marks, M David, Omburo, Stephanie N, Soto-Fuentes, Wilfredo, Tian, Li, Weiblen, George D, Wenger, Jonathan P   +8 more
core  

Reconstruction of Secondary Metabolic Pathway to Synthesize Novel Metabolite in Saccharopolyspora erythraea

Frontiers in Bioengineering and Biotechnology, 2021
Natural polyketides play important roles in clinical treatment, agriculture, and animal husbandry. Compared to natural hosts, heterologous chassis (especially Actinomycetes) have many advantages in production of polyketide compounds.
Chong-Yang Ren, Yong Liu, Yong Liu, Wen-Ping Wei, Junbiao Dai, Bang-Ce Ye, Bang-Ce Ye   +6 more
doaj   +1 more source

Genome‐Guided Discovery of Antimalarial 4‐Amino‐2,4‐Pentadienoate‐Containing Cyclolipodepsipeptides

Angewandte Chemie International Edition, EarlyView.
Halogenated and glycosylated 4‐amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) exhibit potent antiplasmodial activity (IC50 = 25–161 nM) against drug‐sensitive and resistant Plasmodium falciparum strains. ABSTRACT 4‐Amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) represent a structurally distinctive family of ...
Hartono Candra, Xue‐Jiao Wang, Ka Diam Go, Li Feng, Miaomiao Cai, Guang‐Lei Ma, Clarissa Widyantoro, Lik Tong Tan, Zbynek Bozdech, Zhe Wang, Zhao‐Xun Liang   +10 more
wiley   +1 more source