Results 51 to 60 of about 9,310,680 (256)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Dietary iron intake during early pregnancy and birth outcomes in a cohort of British women [PDF]

, 2011
Background: Iron deficiency during pregnancy is associated with adverse birth outcomes, particularly, if present during early gestation. Iron supplements are widely recommended during pregnancy, but evidence of their benefit in relation to infant ...
Greenwood, Darren C, Godfrey, KM, Simpson, NAB, J. E. Cade, McArdle, Harry J, D. C. Greenwood, Greenwood, Darren C., Alwan, NA, Simpson, Nigel A B, Greenwood, DC, Godfrey, Keith M, H. J. McArdle, McArdle, Harry J., Simpson, Nigel A.B., McArdle, HJ, K. M. Godfrey, Alwan, Nisreen A, Cade, Janet E, Cade, Janet E., Cade, JE, N. A. Alwan, N. A. B. Simpson, Alwan, Nisreen A., Godfrey, Keith M.   +23 more
core   +1 more source

Essential Mineral Intake During Pregnancy and Its Association With Maternal Health and Birth Outcomes in South East Queensland, Australia

Nutrition and Metabolic Insights, 2019
Micronutrient supplements are often recommended during pregnancy, yet their role and necessity remain poorly understood in the Australian population. This study aimed to determine the essential mineral intake of a population of pregnant women in South ...
Janelle M McAlpine, Daniel R McKeating, Lisa Vincze, Jessica J Vanderlelie, Anthony V Perkins   +4 more
doaj   +1 more source

Alpha-linolenic acid intake and 10-year incidence of coronary heart disease and stroke in 20,000 middle-aged men and women in the Netherlands. [PDF]

PLoS ONE, 2011
BACKGROUND: Whether intake of alpha-linolenic acid (ALA), the plant-derived n-3 polyunsaturated fatty acid (PUFA), could prevent cardiovascular diseases is not yet clear. We examined the associations of ALA intake with 10-year incidence of coronary heart
Janette de Goede, W M Monique Verschuren, Jolanda M A Boer, Daan Kromhout, Johanna M Geleijnse   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Simulation of the fruit and vegetable intakes meeting the dietary reference intakes of Japanese adults from the National Health and Nutrition Survey

Scientific Reports
Fruit and vegetable intake has been associated with a reduced risk of noncommunicable diseases, however, few studies have assessed the necessary intake of fruits and vegetables to meet nutrient reference values for the dietary reference intake.
Mai Matsumoto, Emiko Okada, Xiaoyi Yuan, Chika Okada, Mayu Kikukawa, Mieko Nakamura, Hidemi Takimoto   +6 more
doaj   +1 more source

Scientific Opinion on Dietary Reference Values for biotin [PDF]

EFSA Journal, 2014
Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) derived Dietary Reference Values (DRVs) for biotin.
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Components of regional population growth, 1986-2001 [PDF]

, 2004
The vitality of a region is frequently assessed by looking at its population growth pattern. This is seen as being linked to its economic and social vibrancy.
Pool, Ian, Baxendine, Sandra, Cochrane, William   +2 more
core