Results 71 to 80 of about 6,865 (203)
Morphine-induced postconditioning modulates mitochondrial permeability transition pore opening via delta-1 opioid receptors activation in isolated rat hearts [PDF]
Korean Journal of Anesthesiology, 2011 BackgroundIt is generally accepted that morphine affords cardioprotection against ischemia/reperfusion injury. Inhibition of the mitochondrial permeability transition pore (MPTP) is considered an end target for cardioprotection. The aim of this study was
June Hong Kim +7 more
doaj +1 more source
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.Sevoflurane (sevo) alleviates ferroptosis in cardiomyocytes and ameliorates MI/RI symptoms by inhibiting HMGB1 expression, reducing ACSL4 stability, and negatively regulating the HMGB1/ACSL4 signaling pathway. ABSTRACT Sevoflurane (sevo) exhibits cardioprotective effects against myocardial ischemia/reperfusion injury (MIRI); however, its precise ...
Yuliu Mei +4 more
wiley +1 more source
MITF Regulates CFTR Expression to Participate in Myocardial Ischemia–Reperfusion Injury
The Journal of Gene Medicine, Volume 28, Issue 8, August 2026.MITF regulates CFTR expression in MIRI, and disruption of the MITF‐CFTR axis is associated with aggravated injury in cellular and animal models. Restoring CFTR partially mitigates MITF deficiency‐related damage. These findings support the involvement of MITF‐CFTR regulation in MIRI and provide a basis for further mechanistic investigation.
Baoxin Tang +4 more
wiley +1 more source
Postconditioning: From the Bench to Bedside
Journal of Cardiovascular Pharmacology and Therapeutics, 2010 Infarct size is determined not only by the severity of ischemia but also by pathological processes initiated at reperfusion. Accumulating experimental evidence indicates that lethal reperfusion injury might account for up to half of the final size of the myocardial infarct.
Martin, Cour +4 more
openaire +2 more sources
Анналы клинической и экспериментальной неврологии, 2017 The aim of the present study was to investigate neuroprotectiveeffects of erythropoietin (EPO), and ischemic pre- and postconditioningin a rat model of focal cerebral ischemia.
A. A. Shmonin +6 more
doaj +1 more source
SIRT Family: Biological Functions and Therapeutic Targets
MedComm, Volume 7, Issue 8, August 2026.SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang +9 more
wiley +1 more source
Effects of OLV preconditioning and postconditioning on lung injury in thoracotomy
Asian Journal of Surgery, 2014 Objective: To observe the effects of intermittent one-lung ventilation (OLV) before and after surgery on the inflammatory cytokines and biomarkers of oxidative stress in serum of lung cancer patients undergoing open thoracotomy.
Yuan-Da Cheng +4 more
doaj +1 more source
Mitochondrial oxidative stress, calcium and dynamics in cardiac ischaemia‐reperfusion injury
The Journal of Physiology, Volume 604, Issue 16, Page 6659-6674, 15 August 2026.Abstract figure legend Heart attack causes ischaemia–reperfusion injury in cardiomyocytes. Mitochondria generate reactive oxygen species (ROS), leading to oxidative stress. High levels of mitochondrial calcium (Ca2+) activate the mitochondrial permeability transition pore (mPTP), and excess ROS levels can lower the Ca2+ required to activate the mPTP ...
Emily Rozich +5 more
wiley +1 more source
Brazilian Journal of Cardiovascular Surgery, 2015 INTRODUCTION: Some publications have demonstrated the presence of lung reperfusion injury in mesenteric ischemia and reperfusion (I/R), but under to diverse methods.
Carlos Henrique Marques dos Santos +7 more
doaj +1 more source
Physiological Reports, Volume 14, Issue 15, August 2026.Abstract The adult Langendorff methodology lacks standardization, with inconsistencies in the pH and calcium concentrations of Krebs–Henseleit (K‐H) solution. The aim of this study was to clarify these inconsistencies. Adult male Wistar rat hearts were subjected to 40 or 80 min of global ischemia followed by reperfusion.
Jan Doul +4 more
wiley +1 more source