Inwardly rectifying potassium channels: Critical insights for insect species and Apis mellifera [PDF]
ChannelsKir (inwardly rectifying potassium) channels that play key roles in maintaining potassium homeostasis, neuronal excitability, and osmoregulation have been cloned and characterized in a variety of insects.
Fabien Sourisseau +3 more
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Involvement of Inwardly Rectifying Potassium (Kir) Channels in the Toxicity of Flonicamid to Drosophila melanogaster [PDF]
InsectsInwardly rectifying potassium (Kir) channels regulate essential physiological processes in insects and have been identified as potential targets for developing new insecticides.
Xuan Liu +5 more
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Reciprocal modulation of IK1-INa extends excitability in cardiac ventricular cells [PDF]
Frontiers in Physiology, 2016 The inwardly rectifying potassium current (IK1) and the fast inward sodium current (INa) are reciprocally modulated in mammalian ventricular myocytes.
Anthony Varghese
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Wine polyphenol resveratrol inhibits contractions of isolated rat uterus by activation of smooth muscle inwardly rectifying potassium channels [PDF]
Veterinarski Glasnik, 2016 Resveratrol is a phytoalexin produced in a number of plant species including grapes. The benefit of resveratrol to health is widely reported. Resveratrol has been found to promote relaxation of non-pregnant and pregnant uterus, but its mechanism
Novaković Radmila +9 more
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Role of Astrocytic Inwardly Rectifying Potassium (Kir) 4.1 Channels in Epileptogenesis
Frontiers in Neurology, 2020 Astrocytes regulate potassium and glutamate homeostasis via inwardly rectifying potassium (Kir) 4.1 channels in synapses, maintaining normal neural excitability.
Masato Kinboshi +3 more
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The Relevance of GIRK Channels in Heart Function
Membranes, 2022 Among the large number of potassium-channel families implicated in the control of neuronal excitability, G-protein-gated inwardly rectifying potassium channels (GIRK/Kir3) have been found to be a main factor in heart control. These channels are activated
Ana Campos-Ríos +2 more
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Frontiers in Pharmacology, 2020 Inwardly rectifying potassium (KIR) channels play important roles in controlling cellular excitability and K+ ion homeostasis. Under physiological conditions, KIR channels allow large K+ influx at potentials negative to the equilibrium potential of K ...
Xingyu Chen +3 more
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Ras-association domain of sorting Nexin 27 is critical for regulating expression of GIRK potassium channels. [PDF]
PLoS ONE, 2013 G protein-gated inwardly rectifying potassium (GIRK) channels play an important role in regulating neuronal excitability. Sorting nexin 27b (SNX27b), which reduces surface expression of GIRK channels through a PDZ domain interaction, contains a putative ...
Bartosz Balana +7 more
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Perisynaptic astrocytes as a potential target for novel antidepressant drugs
Journal of Pharmacological Sciences, 2021 Emerging evidence suggests that dysfunctions in glutamatergic signaling are associated with the pathophysiology of depression. Several molecules that act on glutamate binding sites, so-called glutamatergic modulators, are rapid-acting antidepressants ...
Marcos E. Frizzo, Yukihiro Ohno
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PLoS ONE, 2015 G protein-activated inwardly rectifying potassium (GIRK) channels in 5-HT neurons are assumed to be principal effectors of 5-hydroxytryptamine 1A (5-HT1A) autoreceptors, but their pharmacology, subunit composition and the role in regulation of 5-HT ...
Alberto Montalbano +2 more
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