Results 31 to 40 of about 19,368 (234)
Polyamine Block of Inwardly Rectifying Potassium Channels [PDF]
, 2011 Polyamine blockade of inwardly rectifying potassium (Kir) channels underlies their steep voltage--dependence observed in native cells. The structural determinants of polyamine blockade and the structure-activity profile of endogenous polyamines requires specialized methodology for characterizing polyamine interactions with Kir channels.
Harley T, Kurata +2 more
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The therapeutic agents that target ATP-sensitive potassium channels
Acta Pharmaceutica, 2016 ATP-sensitive potassium (KATP) channels are a major drug target for the treatment of type-2 diabetes. KATP channels are ubiquitously expressed and link the metabolic state to electrical excitability.
Rubaiy Hussein N.
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Journal of Lipid Research, 2019 Cholesterol, a critical component of the cellular plasma membrane, is essential for normal neuronal function. Cholesterol content is highest in the brain, where most cholesterol is synthesized de novo; HMG-CoA reductase controls the synthesis rate ...
Anna N. Bukiya +2 more
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Subunit gating resulting from individual protonation events in Kir2 channels
Nature Communications, 2023 Inwardly rectifying potassium (Kir) channels open at the ‘helix bundle crossing’ (HBC), formed by the M2 helices at the cytoplasmic end of the transmembrane pore.
Grigory Maksaev +5 more
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Frontiers in Cell and Developmental Biology, 2022 Potassium (K+) homeostasis is tightly regulated for optimal cell and organismal health. Failure to control potassium balance results in disease, including cardiac arrythmias and developmental disorders.
Natalie A. Hager +3 more
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Revisit of the Cardiac Inward Rectifier Potassium Current IK1 [PDF]
, 2010 Inward rectifier potassium currents are present in different types of cells. In the heart, the inward rectifier potassium current IK1 plays a crucial role in maintaining cardiac resting membrane potential and excitability. It is generally believed that
Dong, MQ, Li, GR
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Direct modulation of G protein-gated inwardly rectifying potassium (GIRK) channels
Frontiers in PhysiologyIon channels play a pivotal role in regulating cellular excitability and signal transduction processes. Among the various ion channels, G-protein-coupled inwardly rectifying potassium (GIRK) channels serve as key mediators of neurotransmission and ...
Ha Nguyen +2 more
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Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines
BMC Cancer, 2005 Background Previous data from our laboratory has indicated that there is a functional link between the β-adrenergic receptor signaling pathway and the G-protein inwardly rectifying potassium channel (GIRK1) in human breast cancer cell lines. We wanted to
Schuller Hildegard M +3 more
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Voltage‐gated and inwardly rectifying potassium channels [PDF]
The Journal of Physiology, 1997 This lecture is dedicated to Max Delbrück and Seymour Benzer. Max Delbrück was our graduate advisor. He introduced us to a variety of biophysical problems, and taught us ways of thinking about these problems by example. Potassium channels was one of the topics included in his journal club in the early seventies; Max also carefully considered the ...
Lily Yeh Jan, Yuh Nung Jan
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Journal of Pharmacological Sciences, 2014 .: G-protein–activated inwardly rectifying potassium (GIRK) channels are expressed in many tissues and activated by several Gi/o protein–coupled receptors, such as opioid and dopamine receptors, and thus are known to be involved in the modulation of ...
Daisuke Nishizawa +10 more
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