Results 41 to 50 of about 19,368 (234)

Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K+ channels? [PDF]

, 2003
The regulation of ion channels by anionic phospholipids is currently very topical. An outstanding issue is whether phosphatidylinositol 4,5-diphosphate and related species act as true second messengers in signaling or behave in a manner analogous to an ...
Clapp, LH, Cui, Y, Giblin, JP, Quinn, KV, Tinker, A   +4 more
core   +1 more source

Differential polyamine sensitivity in inwardly rectifying Kir2 potassium channels [PDF]

The Journal of Physiology, 2006
Recent studies have shown that Kir2 channels display differential sensitivity to intracellular polyamines, and have raised a number of questions about several properties of inward rectification important to the understanding of their physiological roles.
Panama, Brian K., Lopatin, Anatoli N.
openaire   +3 more sources

Dynamic Modulation of the Microenvironment Promotes Functional Maturation of Engineered Tissues

Advanced Healthcare Materials, EarlyView.
Engineered tissues lack the dynamic microenvironment of native tissues. A biocompatible, diffusible small molecule to dynamically modulate tissue microenvironments during maturation is used. Timing‐dependent modulation yields distinct outcomes, producing thicker, more native‐like blood vessels, stronger and more mature cardiac tissues, and optimized ...
Eric Silberman, Hadas Oved, Itay Gil, Amgad Marzook, Ester Sapir Baruch, Yahel Shechter, Assaf Shapira, Tal Dvir   +7 more
wiley   +1 more source

G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channel Activation by the p75 Neurotrophin Receptor Is Required for Amyloid β Toxicity

Frontiers in Neuroscience, 2017
Alzheimer's disease is characterized by cognitive decline, neuronal degeneration, and the accumulation of amyloid-beta (Aβ). Although, the neurotoxic Aβ peptide is widely believed to trigger neuronal dysfunction and degeneration in Alzheimer's disease ...
Linda M. May, Victor Anggono, Victor Anggono, Helen M. Gooch, Se E. Jang, Se E. Jang, Dusan Matusica, Dusan Matusica, Georg M. Kerbler, Frederic A. Meunier, Frederic A. Meunier, Pankaj Sah, Elizabeth J. Coulson, Elizabeth J. Coulson, Elizabeth J. Coulson   +14 more
doaj   +1 more source

Sequence and function of the two P domain potassium channels: implications of an emerging superfamily. [PDF]

, 1998
A new superfamily of K+ channels has emerged in the past 2 years. Notable for possessing two pore-forming P domains in each subunit, members of the superfamily have been recognized through phylogeny from micro-organisms to humans. Four subfamilies of two
Goldstein, SA, Ilan, N, Pausch, MH, Wang, KW   +3 more
core  

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors

Advanced Science, EarlyView.
Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon, Kyungchul Noh, Minkyu Hwang, Yoon‐Jung Kim, Unjin Lee, Yeon Joo Ryu, Je‐Kyung Ryu, Sang Beom Jun, Se‐Young Choi, Woo‐Hyun Cho, Sung Joong Lee   +10 more
wiley   +1 more source

Potassium dependent regulation of astrocyte water permeability is mediated by cAMP signaling. [PDF]

PLoS ONE, 2012
Astrocytes express potassium and water channels to support dynamic regulation of potassium homeostasis. Potassium kinetics can be modulated by aquaporin-4 (AQP4), the essential water channel for astrocyte water permeability regulation.
Yutong Song, Eli Gunnarson
doaj   +1 more source

Encephalopathy-causing mutations in Gβ1 (GNB1) alter regulation of neuronal GIRK channels

iScience, 2021
Summary: Mutations in the GNB1 gene, encoding the Gβ1 subunit of heterotrimeric G proteins, cause GNB1 Encephalopathy. Patients experience seizures, pointing to abnormal activity of ion channels or neurotransmitter receptors.
Haritha P. Reddy, Daniel Yakubovich, Tal Keren-Raifman, Galit Tabak, Vladimir A. Tsemakhovich, Maria H. Pedersen, Boris Shalomov, Sophie Colombo, David B. Goldstein, Jonathan A. Javitch, Amal K. Bera, Nathan Dascal   +11 more
doaj   +1 more source

Remodelling of human atrial K+ currents but not ion channel expression by chronic β-blockade [PDF]

, 2012
Chronic β-adrenoceptor antagonist (β-blocker) treatment in patients is associated with a potentially anti-arrhythmic prolongation of the atrial action potential duration (APD), which may involve remodelling of repolarising K+ currents.
A Alday, A Maguy, AA Dawodu, AEG Raine, AJ Camm, AJ Workman, AJ Workman, AJ Workman, AJ Workman, AJ Workman, Andrew C. Rankin, Antony J. Workman, B Fermini, CA Karle, CJ Redpath, D Dobrev, D Escande, F Cao, F Lesage, G Bru-Mercier, Gillian E. Marshall, GR Li, J Lopez-Sendon, James O. Tellez, JL Greenstein, JM Nerbonne, JM Nerbonne, John Dempster, Julie A. Russell, Kathleen A. Kane, M Courtemanche, M Courtemanche, M Fink, M Greiser, Mark R. Boyett, N Gaborit, N Niwa, Pardeep S. Jhund, QY Liu, RP Xiao, S Koumi, S Nattel, Susan Currie, SV Pandit, T Christ, U Schotten, W Kong   +46 more
core   +1 more source

P2Y receptor subtypes differentially couple to inwardly‐rectifying potassium channels [PDF]

FEBS Letters, 1998
Subtypes of P2Y receptors are well characterized with respect to their agonist profile but little is known about differences in their intracellular signalling properties. When expressed in Xenopus oocytes, both P2Y2 and P2Y6 receptors effectively couple to endogenous Ca2+‐dependent Cl−‐channels.
Mosbacher, J, Maier, R, Fakler, B, Glatz, A, Crespo, J, Bilbe, G   +5 more
openaire   +2 more sources