Results 1 to 10 of about 30,277 (190)

Pregnenolone Sulfate: From Steroid Metabolite to TRP Channel Ligand

Molecules, 2013
Pregnenolone sulfate is a steroid metabolite with a plethora of actions and functions. As a neurosteroid, pregnenolone sulfate modulates a variety of ion channels, transporters, and enzymes.
Christian Harteneck
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Pregnenolone rescues schizophrenia-like behavior in dopamine transporter knockout mice.

PLoS ONE, 2012
Pregnenolone belongs to a class of endogenous neurosteroids in the central nervous system (CNS), which has been suggested to enhance cognitive functions through GABA(A) receptor signaling by its metabolites.
Peiyan Wong, Cecilia Chin Roei Chang, Christine E Marx, Marc G Caron, William C Wetsel, Xiaodong Zhang   +5 more
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Inhibition by Pregnenolone Sulphate, a Metabolite of the Neurosteroid Pregnenolone, of Voltage-Gated Sodium Channels Expressed in Xenopus Oocytes

Journal of Pharmacological Sciences, 2012
Neurosteroids are known as allosteric modulators of the ligand-gated ion channel superfamily. Voltage-gated sodium channels (Nav) play an important role in mediating excitotoxic damages. Here we report the effects of neurosteroids on the function of Nav,
Takafumi Horishita, Susumu Ueno, Nobuyuki Yanagihara, Yuka Sudo, Yasuhito Uezono, Dan Okura, Takeyoshi Sata   +6 more
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A growth-coupled progesterone-responsive biosensor for high-throughput microfluidic screening in Saccharomyces cerevisiae [PDF]

Synthetic and Systems Biotechnology
Poor aqueous solubility of steroid precursors, such as pregnenolone and progesterone, limits microbial biotransformation and high-throughput strain screening, representing a bottleneck for strain improvement and potential industrial applications.To ...
Yucheng Hu, Jinde Chen, Shaofang Tian, Yang Zhang, Zhiqian Zhang, Ao Jiang, Yi-Rui Wu, Baoshun Zhang   +7 more
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Guanine and pregnenolone sulfate are associated with incident type 2 diabetes in two independent populations [PDF]

Frontiers in Endocrinology
BackgroundType 2 diabetes (T2D) is increasing its burden worldwide; therefore, research focused on its prediction and prevention is essential.MethodsWe performed an untargeted metabolomics analysis using ultra high-performance liquid chromatography-mass ...
Maria Barranco-Altirriba, Maria Barranco-Altirriba, Maria Barranco-Altirriba, Maria Barranco-Altirriba, Minerva Granado-Casas, Minerva Granado-Casas, Minerva Granado-Casas, Minerva Granado-Casas, Oscar Yanes, Oscar Yanes, Jordi Capellades, Jordi Capellades, Alexandra Junza, Alexandra Junza, Josep Franch-Nadal, Josep Franch-Nadal, Joan Vendrell, Joan Vendrell, Gemma Llauradó, Gemma Llauradó, Sergio Valdés, Sergio Valdés, Eva García-Escobar, Eva García-Escobar, Marcelino Bermúdez-López, Marcelino Bermúdez-López, José Manuel Valdivielso, Victor-Miguel López-Lifante, Victor-Miguel López-Lifante, Victor-Miguel López-Lifante, Cecilia Herrero-Alonso, Mireia Falguera, Mireia Falguera, Maria Belén Vilanova, Maria Belén Vilanova, Ingrid Arteaga, Ingrid Arteaga, Pere Torán-Monserrat, Pere Torán-Monserrat, Pere Torán-Monserrat, Alexandre Perera-Lluna, Alexandre Perera-Lluna, Alexandre Perera-Lluna, Esmeralda Castelblanco, Didac Mauricio, Didac Mauricio, Didac Mauricio, Didac Mauricio   +47 more
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Epigenetic dysregulation of steroidogenesis and neuroactive steroid deficiency in premature ovarian insufficiency: implications for neurodegenerative risk [PDF]

Biomarker Research
Premature ovarian insufficiency (POI) is associated with an increased risk of neurodegenerative diseases, but the underlying mechanisms remain unclear.
Qian Wang, Junyan Sun, Lulu Wang, Xuefeng Lin, Liutong Wei, Qiuwan Zhang, Shuang Yuan, Dedong Xin, Dongmei Lai   +8 more
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Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells

Journal of Biological Chemistry, 2023
Neurosteroids, which are steroids synthesized by the nervous system, can exert neuromodulatory and neuroprotective effects via genomic and nongenomic pathways.
Yiqi Christina Lin, Garett Cheung, Zeyu Zhang, V. Papadopoulos   +3 more
semanticscholar   +1 more source

Pregnenolone for the treatment of L-DOPA-induced dyskinesia in Parkinson's disease.

Experimental Neurology, 2023
Growing preclinical and clinical evidence highlights neurosteroid pathway imbalances in Parkinson's Disease (PD) and L-DOPA-induced dyskinesias (LIDs).
Corsi Sara, Scheggi Simona, Pardu Alessandra, Braccagni Giulia, Caruso Donatella, Cioffi Lucia, Diviccaro Silvia, G. Mauro, Fanni Silvia, Stancampiano Roberto, Gambarana Carla, Melcangi Roberto Cosimo, Frau Roberto, Carta Manolo   +13 more
semanticscholar   +1 more source

The neurosteroid pregnenolone is synthesized by a mitochondrial P450 enzyme other than CYP11A1 in human glial cells

Journal of Biological Chemistry, 2022
Neurosteroids, modulators of neuronal and glial cell functions, are synthesized in the nervous system from cholesterol. In peripheral steroidogenic tissues, cholesterol is converted to the major steroid precursor pregnenolone by the CYP11A1 enzyme ...
Yiqi Christina Lin, Garett Cheung, E. Porter, V. Papadopoulos   +3 more
semanticscholar   +1 more source

Alcohol and pregnenolone interaction on cerebral arteries through targeting of vascular smooth muscle Ca2+- and voltage-gated K+ channels of big conductance

Advances in Drug and Alcohol Research, 2023
Despite the significant number of people who may be taking pregnenolone supplements while drinking alcohol (ethanol), the widely documented cerebrovascular actions of pregnenolone and ethanol, and the critical dependence of cerebrovascular function on ...
Kelsey C. North, Andrew A. Shaw, Luiz Moreira, Anna N. Bukiya, Alex M. Dopico   +4 more
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