Results 11 to 20 of about 30,346 (255)

[Pregnenolone]. [PDF]

Nihon rinsho. Japanese journal of clinical medicine, 2020
Interpretive Information • Congenital adrenal hyperplasia • Adrenal virilizing tumor • Cushing’s disease • Normal children and adults after ACTH administration Clinical Background Normal steroid-producing cells of the adrenal glands and gonads synthesize
S. Nakamura, S. Mikami, T. Futoeda
semanticscholar   +2 more sources

Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders

Cell Metabolism, 2022
Summary Obesity and type 2 diabetes are associated with cognitive dysfunction. Because the hypothalamus is implicated in energy balance control and memory disorders, we hypothesized that specific neurons in this brain region are at the interface of ...
Sara Ramírez, Roberta Haddad-Tóvolli, Marija Radosevic, Míriam Toledo, Adriana Pané, D. Alcolea, V. Ribas, M. Milà-Guasch, Macarena Pozo, Arnaud Obri, Elena Eyre, A. Gómez-Valadés, Iñigo Chivite, Tomas Van Eeckhout, I. Zalachoras, J. Altirriba, Corinna A. Bauder, M. Imbernón, G. Garrabou, C. Garcia-Ruiz, R. Nogueiras, David Soto, X. Gasull, C. Sandi, J. Brüning, J. Fortea, Amanda Jiménez, J. Fernández-Checa, M. Claret   +28 more
semanticscholar   +1 more source

Pregnenolone Inhibits Doxorubicin-Induced Cardiac Oxidative Stress, Inflammation, and Apoptosis—Role of Matrix Metalloproteinase 2 and NADPH Oxidase 1

Pharmaceuticals, 2023
The clinical usefulness of doxorubicin (DOX) is limited by its serious adverse effects, such as cardiotoxicity. Pregnenolone demonstrated both anti-inflammatory and antioxidant activity in animal models.
Mohamed A. Morsy, Seham A. Abdel-Gaber, Sahar A. Mokhemer, Mahmoud Kandeel, Wael F. Sedik, Anroop B. Nair, Katharigatta N. Venugopala, Hany Ezzat Khalil, Bandar E. Al-Dhubiab, Mervat Z. Mohamed   +9 more
doaj   +1 more source

Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder

Biomolecules, 2022
Chronic cocaine use leads to adaptations in stress biology and in neuroactive steroid system. These adaptations are associated with high cocaine craving and increased relapse risk.
Verica Milivojevic, Lily Charron, Nia Fogelman, Gretchen Hermes, Rajita Sinha   +4 more
doaj   +1 more source

Comparison of pregnenolone sulfate, pregnanolone and estradiol levels between patients with menstrually-related migraine and controls: an exploratory study

The Journal of Headache and Pain, 2021
Background Neurosteroids affect the balance between neuroexcitation and neuroinhibition but have been little studied in migraine. We compared the serum levels of pregnenolone sulfate, pregnanolone and estradiol in women with menstrually-related migraine ...
Cecilia Rustichelli, Elisa Bellei, Stefania Bergamini, Emanuela Monari, Flavia Lo Castro, Carlo Baraldi, Aldo Tomasi, Anna Ferrari   +7 more
doaj   +1 more source

Investigation of urinary steroid metabolites in calf urine after oral and intramuscular administration of DHEA [PDF]

, 2010
DHEA (3ß-hydroxy-androst-5-en-17-one) is a natural steroid prohormone. Despite a lack of information on the effect, DHEA and other prohormones are frequently used as a food supplement by body-builders.
Becue, I., Bovee, T.F.H., Nielen, M.W.F., Peteghem, C., van, Poucke, C., Rijk, J.C.W.   +5 more
core   +5 more sources

Effect of Pregnenolone vs Placebo on Self-reported Chronic Low Back Pain Among US Military Veterans

JAMA Network Open, 2020
Key Points Question Does adjunctive treatment with pregnenolone improve chronic low back pain in Iraq- and Afghanistan-era US military veterans? Findings The use of pregnenolone in this randomized, double-blind, placebo-controlled clinical trial in 94 ...
J. Naylor, J. Naylor, J. Kilts, J. Kilts, L. Shampine, L. Shampine, Gillian J. Parke, Gillian J. Parke, H. R. Wagner, H. R. Wagner, Steven T. Szabo, Steven T. Szabo, Karen D. Smith, Karen D. Smith, Trina B. Allen, Emily G. Telford-Marx, C. Dunn, Brian T. Cuffe, Brian T. Cuffe, Susan H. O’Loughlin, Susan H. O’Loughlin, Christine E. Marx, Christine E. Marx   +22 more
semanticscholar   +1 more source

Neuroactive steroids in depression and anxiety disorders: Clinical studies [PDF]

, 2006
Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Akwa Y, Baghai TC, Baker ER, Barrett-Connor E, Bicikova M, Bitran D, Bloch M, Brambilla F, Brambilla F, Brambilla F, Cornelius Schüle, Crawley JN, Dalton K, Daniela Eser, Dennerstein L, Dong E, Elena Romeo, Eser D, Evans RM, Fabian TJ, Freeman E, Freeman EW, Friess E, George MS, Goodyer IM, Guidotti A, Heydari B, Heydary B, Kita A, Koszycki D, Lawrie TA, Maayan R, Magill PJ, Majewska MD, Majewska MD, Majewska MD, Matsumoto K, Meieran SE, Melchior CL, Melchior CL, Mensah-Nyagan AG, Mienville JM, Monnet FP, Padberg F, Papadopoulos V, Paul SM, Purdy RH, Rainer Rupprecht, Reddy DS, Reddy DS, Reddy DS, Rodgers RJ, Romeo E, Rupprecht R, Rupprecht R, Schmidt PJ, Schule C, Schule C, Semeniuk T, Serra M, Serra M, Strohle A, Strohle A, Strohle A, Strous RD, Takebayashi M, Thomas C. Baghai, Tollefson GD, Trauger JW, Urani A, Uzunov DP, Uzunova V, Uzunova V, Uzunova V, Vanselow W, Wieland S, Wolkowitz OM, Wolkowitz OM, Wu FS, Zwanzger P   +79 more
core   +1 more source

Biosynthesis and Industrial Production of Androsteroids

Plants, 2020
Steroids are a group of organic compounds that include sex hormones, adrenal cortical hormones, sterols, and phytosterols. In mammals, steroid biosynthesis starts from cholesterol via multiple steps to the final steroid and occurs in the gonads, adrenal ...
Rituraj Batth, Clément Nicolle, Ilenuta Simina Cuciurean, Henrik Toft Simonsen   +3 more
doaj   +1 more source

Analysis of salivary steroid hormones in boys with autism spectrum disorder

BMC Psychiatry, 2023
Background Autism spectrum disorders (ASD) is a neurodevelopmental disorder with high incidence rate and difficult diagnosis. The purpose of this study was to explore whether salivary cortisol, dehydroepiandrosterone (DHEA) and pregnenolone can be used ...
Qing He, Ying Wang, Zhichao Liu, Jinrong Xia, Heng Yin, Zhongqing Qiu, Hui Wang, Wenming Xu, Zhe Xu, Jiang Xie   +9 more
doaj   +1 more source