Development and application of an UHPLC-MS/MS method for the simultaneous determination of 17 steroidal hormones in equine serum [PDF]
, 2017 A new, fast and simple analytical method that is able to identify and quantify simultaneously 17 steroid hormones and metabolites (Pregnenolone, 17-OH-Pregnenolone, Progesterone, 17-OH Progesterone, Androsterone, Androstenedione, DHEA, DHEAS ...
Allis +20 more
core +1 more source
The Ability of Pregnenolone in Proliferation of Mouse Neural Stem Cells and Reduction of Inflammatory and Oxidant Markers after Induction of Inflammation with Lipopolysaccharide in Vitro [PDF]
Armaghane Danesh Bimonthly Journal, 2023 Background & aim: Pregnenolone acts as a precursor to other steroid hormones and exerts its effect as an anti-inflammatory molecule to maintain immune homeostasis in various inflammatory conditions. In these diseases, a decrease in the level ofP has been
K Negintaji +3 more
doaj
Biomolecules, 2022 The treatment with finasteride (i.e., an inhibitor of 5α-reductase) may be associated with different side effects (i.e., depression, anxiety, cognitive impairment and sexual dysfunction) inducing the so-called post finasteride syndrome (PFS).
Silvia Diviccaro +6 more
doaj +1 more source
Metabolic profiling of human plasma and urine in chronic kidney disease by hydrophilic interaction liquid chromatography coupled with time-of-flight mass spectrometry : a pilot study [PDF]
, 2017 A typical characteristic of chronic kidney disease (CKD) is the progressive loss in renal function over a period of months or years with the concomitant accumulation of uremic retention solutes in the body.
Boelaert, Jente +5 more
core +1 more source
The endogenic neurosteroid system and its role in the pathogenesis and therapy of mental disorders
Research Results in Pharmacology, 2023 Introduction: Although neurosteroids have been relatively recently discovered, their significant role in the neurochemical processes and pathogenesis of a number of psychiatric and neurological disorders is now quite clear.
Sakeena P. Bairamova +7 more
doaj +1 more source
Frontiers in Immunology, 2023 Pregnenolone (P5) is synthesized as the first bioactive steroid in the mitochondria from cholesterol. Clusters of differentiation 4 (CD4+) and Clusters of differentiation 8 (CD8+) immune cells synthesize P5 de novo; P5, in turn, play important role in ...
Sougata Roy +9 more
doaj +1 more source
Resonance Raman Spectroscopy Reveals that Substrate Structure Selectively Impacts the Heme-Bound Diatomic Ligands of CYP17 [PDF]
, 2013 An important function of steroidogenic cytochromes P450 is the transformation of cholesterol to produce androgens, estrogens, and the corticosteroids.
Gregory, Michael C. +3 more
core +2 more sources
Prenatal THC exposure produces a hyperdopaminergic phenotype rescued by pregnenolone
Nature Neuroscience, 2019 The increased legal availability of cannabis has led to a common misconception that it is a safe natural remedy for, among others, pregnancy-related ailments such as morning sickness.
R. Frau +13 more
semanticscholar +1 more source
Impact of Intraventricular Human Adipose-Derived Stem Cells Transplantation with Pregnenolone Treatment on Remyelination of Corpus Callosum in A Rat Model of Multiple Sclerosis [PDF]
Cell Journal, 2022 ObjectiveMultiple sclerosis (MS) is known as a nerve tissue disorder, which causes demyelination of central nervoussystem (CNS) fibers. Cell-based treatment is a novel strategy for the treatment of demyelinating diseases such asMS.
Mohammad Mardani +4 more
doaj
The "backdoor pathway" of androgen synthesis in human male sexual development. [PDF]
, 2019 Mammalian sex determination (male versus female) is largely controlled by genes, whereas sex differentiation (development of reproductive structures) is largely controlled by hormones. Work in the 20th century indicated that female external anatomy was a
Auchus, Richard J, Miller, Walter L
core +2 more sources