Results 31 to 40 of about 30,346 (255)
Pregnenolone and pregnenolone sulfate metabolism by human fetal testes in vitro [PDF]
Steroids, 1970 Abstract Homogenates of testes from human fetuses of 12–16 weeks gestation were incubated in vitro with pregnenolone-4- 14 C and pregnenolone-7- 3 H-sulfate. Dehydroepiandrosterone sulfate and pregnenediol sulfate, each bearing the tritium label only, were identified in the conjugated fraction.
Lamont, Kenneth G. +3 more
openaire +2 more sources
Journal of Biological Chemistry, 2019 Pregnenolone is a steroid hormone precursor that is synthesized in various steroidogenic tissues, in the brain, and in lymphocytes. In addition to serving as the precursor for other steroid hormones, pregnenolone exerts its own effect as an anti ...
Subathra Murugan +4 more
semanticscholar +1 more source
Gut Steroids and Microbiota: Effect of Gonadectomy and Sex
Biomolecules, 2022 Sex steroids, derived mainly from gonads, can shape microbiota composition; however, the impact of gonadectomy and sex on steroid production in the gut (i.e., gut steroids), and its interaction with microbiota composition, needs to be clarified.
Silvia Diviccaro +9 more
doaj +1 more source
Steroids and Brain, a Rising Bio-Medical Domain: a Perspective
Frontiers in Endocrinology, 2018 Some newly described steroid-related compounds, also found in the rest of the body, are formed and active in the central nervous system, particularly in the brain. Some are of pharmacological and physiopathological interest. We specifically report on two
Etienne-Emile Baulieu
doaj +1 more source
Homozygous disruption of P450 side-chain cleavage (CYP11A1) is associated with prematurity, complete 46,XY sex reversal, and severe adrenal failure [PDF]
, 2005 Disruption of the P450 side-chain cleavage cytochrome (P450scc) enzyme due to deleterious mutations of the CYP11A1 gene is thought to be incompatible with fetal survival because of impaired progesterone production by the fetoplacental unit.
Achermann, JC +8 more
core +1 more source
Analysis of Corticosterone and Testosterone Synthesis in Rat Salivary Gland Homogenates
Frontiers in Endocrinology, 2019 Extra-adrenal steroid hormone production has been reported in several tissues, the biological role of which is interesting in terms of hormonal regulation of metabolism, growth, and behavior. In this report, we describe for the first time steroidogenesis
Takahiro Ieko +5 more
doaj +1 more source
eLife, 2020 The glucose-sensing Mondo pathway regulates expression of metabolic genes in mammals. Here, we characterized its function in the zebrafish and revealed an unexpected role of this pathway in vertebrate embryonic development.
Meltem Weger +15 more
doaj +1 more source
Applied Sciences, 2021 The response of synthetic substrates of sex steroid hormones—cholesterol (CHO), pregnenolone (PREG), and progesterone (PROG)—in the serum and testes of male tilapia (Oreochromis niloticus) to the environmental estrogen pesticide methomyl (0.2, 2, 20, and
Shunlong Meng +7 more
doaj +1 more source
A pilot study comparing the metabolic profiles of elite-level athletes from different sporting disciplines [PDF]
, 2018 Background: The outstanding performance of an elite athlete might be associated with changes in their blood metabolic profile. The aims of this study were to compare the blood metabolic profiles between moderate- and high-power and endurance elite ...
A Boldyrev +51 more
core +1 more source
TSPO Ligands Boost Mitochondrial Function and Pregnenolone Synthesis
Journal of Alzheimer's Disease, 2019 Translocator protein 18 kDa (TSPO) is located in the mitochondrial outer membrane and plays an important role in steroidogenesis and cell survival. In the central nervous system (CNS), its expression is upregulated in neuropathologies such as Alzheimer’s
I. Lejri +10 more
semanticscholar +1 more source