Results 41 to 50 of about 30,346 (255)

Effects of Oestrogens and FSH on LH Stimulation of Steroid Production by Testis Leydig Cells from Immature Rats [PDF]

, 1978
Hypophysectomy of immature male rats results after 5 days in a decreased production of testosterone by isolated testis Leydig cells in response to LH. The LH responsiveness of the Leydig cells can be partly restored by treatment of the hypophysectomized ...
Beurden-Lamers, W.M.O. (Wilma) van, Roodnat, B. (Bep), van der Molen, H.J. (Henk J.)   +2 more
core   +8 more sources

Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202 [PDF]

, 2018
CYP17A1 is a key steroidogenic enzyme known to conduct several distinct chemical transformations on multiple substrates. In its hydroxylase activity, this enzyme adds a hydroxyl group at the 17α position of both pregnenolone and progesterone at ...
Bangcharoenpaurpong O., James R. Kincaid, Mak P. J., Michael C. Gregory, Nakajin S., Piotr J. Mak, Shen A. L., Stephen G. Sligar, Yogan Khatri   +8 more
core   +2 more sources

Stress and drug abuse-related disorders: the promising therapeutic value of neurosteroids Focus on Pregnenolone-Progesterone-Allopregnanolone pathway.

Frontiers in neuroendocrinology (Print), 2019
The pregnenolone-progesterone-allopregnanolone pathway is receiving increasing attention in research on the role of neurosteroids in pathophysiology, particularly in stress-related and drug use disorders. These disorders involve an allostatic change that
G. Tomaselli, M. Vallée
semanticscholar   +1 more source

The effect of progesterone and pregnenolone on diabetes status in Chinese rural population: a dose-response analysis from Henan Rural Cohort.

European Journal of Endocrinology, 2019
OBJECTIVE Previous studies have uncovered a progestin-only contraceptive association with an increased risk of diabetes, but limited study has explored the relationship of endogenous progesterone and pregnenolone level with diabetes status.
Jingjing Jiang, Xue Liu, Xiaotian Liu, Z. Tian, Haiqing Zhang, Xinling Qian, Zhicheng Luo, D. Wei, Shuna Jin, Chongjian Wang, Z. Mao   +10 more
semanticscholar   +1 more source

Pregnenolone blocks cannabinoid-induced acute psychotic-like states in mice

Molecular Psychiatry, 2017
Cannabis-induced acute psychotic-like states (CIAPS) represent a growing health issue, but their underlying neurobiological mechanisms are poorly understood. The use of antipsychotics and benzodiazepines against CIAPS is limited by side effects and/or by
A. Busquets-García, E. Soria‐Gomez, B. Redon, Yarmo Mackenbach, F. Chaouloff, Marjorie Varilh, G. Ferreira, P. Piazza, G. Marsicano   +8 more
semanticscholar   +1 more source

Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1

Journal of Biological Chemistry, 2017
Cytochrome P450 (P450, CYP) 17A1 plays a critical role in steroid metabolism, catalyzing both the 17α-hydroxylation of pregnenolone and progesterone and the subsequent 17α,20-lyase reactions to form dehydroepiandrosterone (DHEA) and androstenedione ...
E. Gonzalez, F. Guengerich
semanticscholar   +1 more source

Mapping molluscan endocrinology: a systematic and critical appraisal. [PDF]

Biol Rev Camb Philos Soc
ABSTRACT Historically, a vertebrate‐centric paradigm has framed our interpretation of molluscan endocrinology, with considerable research focusing on vertebrate‐type steroid hormones (e.g. oestrogens, testosterone). However, contradictory evidence on the occurrence of vertebrate‐type steroid hormones in molluscan tissues, and a lack of the specific ...
Panagiotidis K, Miller TH, Martin OV, Baynes A.   +3 more
europepmc   +2 more sources

TSPO: kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria [PDF]

, 2016
The 18-kDa translocator protein (TSPO) localizes in the outer mitochondrial membrane (OMM) of cells and is readily up-regulated under various pathological conditions such as cancer, inflammation, mechanical lesions and neurological diseases. Able to bind
Aghazadeh, Aghazadeh, Alho, Amitani, Anholt, Anholt, Anholt, Anholt, Antkiewicz-Michaluk, Arbo, Banati, Banati, Bar-Ami, Barron, Basile, Batarseh, Batarseh, Batarseh, Batarseh, Batra, Beinlich, Benavides, Bernassau, Besman, Bird, Bitran, Bose, Boujrad, Boujrad, Braestrup, Bribes, Bribes, Brunette, Cagnin, Campanella, Campioli, Casellas, Chauveau, Chen, Chen, Cho, Clark, Colasanti, Corcia, Costa, Costa, Costa, Cuhlmann, Daugherty, De Souza, Decaudin, Decker, Delavoie, Delerive, Doperalski, Enders, Epstein, Fafalios, Fan, Fan, Fan, Fur, Fur, Galiegue, Gastaldello, Gatliff, Gatliff, Gavish, Gavish, Gazouli, Gehlert, Gerhard, Gervois, Giatti, Giatzakis, Giatzakis, Golani, Gonzalez-Polo, Guillon, Gulyas, Guo, Guo, Gut, Hardwick, Hardwick, Hauet, Hauet, Jamin, Jaremko, Jaremko, Jemma Gatliff, Joo, Joseph-Liauzun, Karlstetter, Kita, Kondo, Konigsrainer, Korkhov, Kreisl, Kruczek, Kumar, Lacapere, Lacapere, Lavisse, Li, Li, Li, Li, Li, Li, Libby, Liu, Liu, Maia, Maury, Mazurika, McEnery, Miao, Michelangelo Campanella, Midzak, Midzak, Miettinen, Miller, Mills, Mizrahi, Morohaku, Murail, Nagler, Obame, Oberto, Olson, Ostuni, Ouchi, Owen, Owen, Owen, Papadopoulos, Papadopoulos, Papadopoulos, Papadopoulos, Papadopoulos, Papadopoulos, Papadopoulos, Paradis, Pastorino, Pelechano, Petrescu, Poynter, Raghavan, Rey, Romeo, Rone, Rosenberg, Rosenberg, Rosenberg, Rupprecht, Rupprecht, Scarf, Schaller, Selvaraj, Shoukrun, Sileikyte, Soustiel, Sutter, Tang, Taylor, Teboul, Thompson, Trincavelli, Tu, Tu, Tu, Vanhee, Varrone, Vega, Verma, Wang, Wang, Wei, Whalin, Xiao, Yang, Yang, Yasuno, Yeliseev, Yoder, Zhang, Zhang, Zhao, Zhou   +189 more
core   +1 more source

Clock-Controlled Mitochondrial Dynamics Correlates with Cyclic Pregnenolone Synthesis

Cells, 2020
Neurosteroids are steroids synthetized in the nervous system, with the first step of steroidogenesis taking place within mitochondria with the synthesis of pregnenolone. They exert important brain-specific functions by playing a role in neurotransmission,
Melissa Witzig, Amandine Grimm, Karen Schmitt, Imane Lejri, Stephan Frank, Steven A. Brown, Anne Eckert   +6 more
doaj   +1 more source

Single-Cell RNA Sequencing Reveals T Helper Cells Synthesizing Steroids De Novo to Contribute to Immune Homeostasis

Cell Reports, 2014
T helper 2 (Th2) cells regulate helminth infections, allergic disorders, tumor immunity, and pregnancy by secreting various cytokines. It is likely that there are undiscovered Th2 signaling molecules.
Bidesh Mahata, Xiuwei Zhang, Aleksandra A. Kolodziejczyk, Valentina Proserpio, Liora Haim-Vilmovsky, Angela E. Taylor, Daniel Hebenstreit, Felix A. Dingler, Victoria Moignard, Berthold Göttgens, Wiebke Arlt, Andrew N.J. McKenzie, Sarah A. Teichmann   +12 more
doaj   +1 more source