Results 61 to 70 of about 30,346 (255)

Pregnenolone sulfate normalizes schizophrenia-like behaviors in dopamine transporter knockout mice through the AKT/GSK3β pathway

Translational Psychiatry, 2015
Pregnenolone sulfate, an endogenous neurosteroid in the central nervous system, is a positive allosteric modulator of the NMDA receptor, and plays a role in the modulation of learning and memory.
Peiyan Wong, Y. Sze, Cecilia Chin Roei Chang, J. Lee, Xiaodong Zhang   +4 more
semanticscholar   +1 more source

Liver X Receptor α (LXRα) Regulates 5β‐Reductase (AKR1D1) Expression in Avian Embryos: Implications for Yolk Steroid Metabolism

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Steroid‐mediated maternal effects are well‐studied as a source of phenotypic variation. In bird eggs, the yolk contains various steroids that can influence embryonic development. However, one complicating factor in understanding how yolk steroids affect development is that the embryo metabolizes yolk steroids to regulate exposure.
Ryan T. Paitz, Sara E. Waters, Delaney K. Reynolds, Emily M. Drew, Emily P. Harders   +4 more
wiley   +1 more source

Neurosteroids Progesterone and Dehydroepiandrosterone: Molecular Mechanisms of Action in Neuroprotection and Neuroinflammation

Pharmaceuticals
Neurosteroids pregnenolone, progesterone, allopregnanolone, and dehydroepiandrosterone have been actively studied in the last years as candidates for the treatment of neurodegenerative diseases and postinjury rehabilitation.
Tatiana A. Fedotcheva, Nikolay L. Shimanovsky   +1 more
doaj   +1 more source

Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)

Phytotherapy Research, EarlyView.
ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley   +1 more source

Maternal steroids during pregnancy and their associations with ambient air pollution and temperature during preconception and early gestational periods

Environment International, 2022
Hormones play critical roles in facilitating pregnancy progression and the onset of parturition. Several classes of environmental contaminants, including fine particulate matter (PM2.5) and ambient temperature, have been shown to alter hormone ...
Elena Colicino, Whitney Cowell, Nicolo Foppa Pedretti, Anu Joshi, Oulhote Youssef, Allan C. Just, Itai Kloog, Lauren Petrick, Megan Niedzwiecki, Robert O. Wright, Rosalind J. Wright   +10 more
doaj   +1 more source

Evidence That Cytochrome \u3cem\u3eb\u3csub\u3e5\u3c/sub\u3e\u3c/em\u3e Acts as a Redox Donor in CYP17A1 Mediated Androgen Synthesis [PDF]

, 2016
Cytochrome P450 17A1 (CYP17A1) is an important drug target for castration resistant prostate cancer. It is a bi-functional enzyme, catalyzing production of glucocorticoid precursors by hydroxylation of pregnene-nucleus, and androgen biosynthesis by a ...
Denisov, Ilia G., Duggal, Ruchia, Gregory, Michael C., Kincaid, James R., Liu, Yilin, Sligar, Stephen G.   +5 more
core   +1 more source

Stress and Exercise [PDF]

, 2007
Age-related immunological and endocrinological changes may have implications for resilience to stress in older adults. We hypothesise that the combination of adrenopause and immunesenescence may leave this population particularly vulnerable to the ...
Bauer, Butcher, Butcher, Butcher, Emery, Fleshner, Globerson, Graham, Hawkley, Kemmler, Kiecolt-Glaser, Kohut, Kohut, Kohut, Leveille, O'Donnell, Ogata, Orentreich, Phillips, Segerstrom, Vedhara, Vedhara   +21 more
core   +1 more source

Evaluation of a non‐radioactive rapid test for determination of serum progesterone in South American camelids

Veterinary Record, EarlyView.
Abstract Background Determination of the serum progesterone (P4) concentration is of high importance in reproductive medicine and may be applied for diagnosing pregnancy in South American camelids. P4 measurements in alpacas and llamas are usually performed using immunoassays, which are time consuming and require appropriate expertise of laboratory ...
Lina Längerer, Gerhard Schuler, Philipp Pohlscheid, Henrik Wagner, Kathrin Büttner, Axel Wehrend   +5 more
wiley   +1 more source

Evaluation of cortisol precursors for the diagnosis of pituitary-dependent hypercortisolism in dogs [PDF]

, 2008
The serum concentrations of cortisol, 17alpha-hydroxypregnenolone, 17alpha-hydroxyprogesterone, 21-deoxycortisol and 11-deoxycortisol were measured in 19 healthy dogs, 15 dogs with pituitary-dependent hypercortisolism (pdh) and eight dogs with other ...
Boretti, Felicitas S, Maser-Gluth, C, Reusch, Claudia E, Sieber-Ruckstuhl, Nadja S, Wenger, M   +4 more
core   +1 more source

Pharmacological and Mechanistic Interventions for Cognitive Impairment Associated With Schizophrenia: A Review of Registered Clinical Trials

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian, Lena Palaniyappan, Theodore T. Kolivakis, Howard C. Margolese   +3 more
wiley   +1 more source