Results 81 to 90 of about 30,346 (255)

Neuroactive Steroids, Toll-like Receptors, and Neuroimmune Regulation: Insights into Their Impact on Neuropsychiatric Disorders

Life
Pregnane neuroactive steroids, notably allopregnanolone and pregnenolone, exhibit efficacy in mitigating inflammatory signals triggered by toll-like receptor (TLR) activation, thus attenuating the production of inflammatory factors.
Irina Balan, Giorgia Boero, Samantha Lucenell Chéry, Minna H. McFarland, Alejandro G. Lopez, A. Leslie Morrow   +5 more
doaj   +1 more source

Microbial Hydroxylation of Pregnenolone Derivatives

Chemical and Pharmaceutical Bulletin, 2005
Pregnenolone and pregnenolone acetate were incubated with the fungi Cunninghamella elegans, Rhizopus stolonifer and Gibberella fujikuroi. Incubation of with C. elegans yielded metabolites, 3beta,7beta,11alpha-trihydroxypreg-5-en-20-one, 3beta,6alpha,11alpha,12beta,15beta-pentahydroxypreg-4-en-20-one and 3beta,6beta,11alpha-trihydroxypreg-4-en-20-one ...
Muhammad Iqbal, Choudhary, Iffat, Batool, Syed Adnan Ali, Shah, Sarfraz Ahmad, Nawaz, , Atta-ur-Rahman   +4 more
openaire   +3 more sources

Opening closed inward rectifier potassium channel doors

British Journal of Pharmacology, EarlyView.
Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger, Fabian Kaiser, Marcel A. G. van der Heyden, Saïd Bendahhou   +3 more
wiley   +1 more source

Pharmacological effect of one icv dose of Allopregnanolone in female rat: behavioural profile [PDF]

, 2015
We have previously observed that intracerebroventricular allopregnanolone (ALLO) injection produced an anxiolytic effect and inhibited sexual receptivity when the test was performed in a separate manner. Also, ALLO reverts learning deficit in female rats
Cabrera Kreiker, Ricardo Jorge, Escudero, Carla Gimena, García Menéndez, Sebastián Marcelo Manuel, Giuliani, Fernando Alfredo, Laconi, Myriam Raquel, Pelegrina, Laura Tatiana   +5 more
core  

Probing GABAA receptors with inhibitory neurosteroids [PDF]

, 2018
γ-aminobutyric acid type A receptors (GABAARs) are important components of the central nervous system and they are functionally tasked with controlling neuronal excitability.
Bright, DP, Seljeset, S, Smart, TG, Thomas, P   +3 more
core   +1 more source

Pregnenolone, a cholesterol metabolite, induces glioma cell apoptosis via activating extrinsic and intrinsic apoptotic pathways

Oncology Letters, 2014
Gliomas are one of the most common types of malignant tumors worldwide, however, an effective therapeutic strategy not yet been fully determined. The present study aimed to investigate the anti-glioma activity and underlying mechanisms of pregnenolone ...
Xiao Xiao, Lijun Chen, Y. Ouyang, Wenbo Zhu, P. Qiu, Xinwen Su, Yun-ling Dou, Lipeng Tang, Min Yan, Haipeng Zhang, Xiaoxiao Yang, Dong-Hui Xu, Guangmei Yan   +12 more
semanticscholar   +1 more source

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, EarlyView.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

Mechanism of the Dual Activities of Human CYP17A1 and Binding to Anti-Prostate Cancer Drug Abiraterone Revealed by a Novel V366M Mutation Causing 17,20 Lyase Deficiency

Pharmaceuticals, 2018
The CYP17A1 gene regulates sex steroid biosynthesis in humans through 17α-hydroxylase/17,20 lyase activities and is a target of anti-prostate cancer drug abiraterone.
Mónica Fernández-Cancio, Núria Camats, Christa E. Flück, Adam Zalewski, Bernhard Dick, Brigitte M. Frey, Raquel Monné, Núria Torán, Laura Audí, Amit V. Pandey   +9 more
doaj   +1 more source

Aminoglutethimide prevents excitotoxic and ischemic injuries in cortical neurons [PDF]

, 2006
Aminoglutethimide is a clinically available drug that suppresses steroid biosynthesis by inhibiting enzymes such as cytochrome P450scc and aromatase. Because several members of neurosteroids regulate glutamate receptors, we investigated the effect of ...
Hisashi Shirakawa, Hiroshi Katsuki, Toshiaki Kume, Shuji Kaneko, Akinori Akaike, ALSHOWAIER, BASTIDA, COIRINI, DI SALLE, FOSTER, FUJIMOTO, GUARNERI, HOLMES, IRWIN, KATSUKI, KIMONIDES, KURATA, MARAGAKIS, MATTSON, MELDRUM, MELLON, MILLER, MILLER, NEDERGAARD, NISHIZAWA, PARK-CHUNG, REDDY, ROBEL, SALHANICK, SHIRAKAWA, SHIRAKAWA, UNGER, VEIGA, WEAVER, WEAVER, WEAVER, WU, YAGHOUBI, ZWAIN   +38 more
core   +2 more sources

Identification of Compound Heterozygous CYP11A1 Variants via Reanalysis of Clinical Sequencing Data

American Journal of Medical Genetics Part A, Volume 200, Issue 4, Page 923-928, April 2026.
ABSTRACT A molecular diagnosis is currently achievable in approximately 50% of patients assessed by clinical geneticists at tertiary care centres. Next‐Generation Sequencing Panels contain a defined group of genes associated with a clinically defined set of phenotypes.
Ana Acosta Bedón, Vahid Akbari, Ralph Rothstein, Alexandra Inman, Sanjiv Bhalla, Jianghong An, Jan M. Friedman, Rosanna Weksberg, Cornelius Boerkoel, Steven J. M. Jones, William T. Gibson   +10 more
wiley   +1 more source