Results 31 to 40 of about 2,389 (154)

NICE: A Two‐Step Non‐Invasive Framework for Embryo cfDNA Read Enrichment and Quality Assessment

Advanced Science, EarlyView.
The non‐invasive NICE framework, built on an ensemble stacking machine learning model, prioritizes embryos by analyzing cell‐free DNA from spent culture medium. By integrating multimodal signals, including genomic and epigenetic profiles, this automated approach standardizes morphological assessment without human bias, paving the way for more precise ...
Xueya Zhou, Shu Ding, Zhenyi Zhang, Qiaoling Shangguan, Jie Qiao, Peijie Zhou, Yidong Chen   +6 more
wiley   +1 more source

PREIMPLANTATION GENETIC TESTING: Clinical experience of preimplantation genetic testing [PDF]

Reproduction, 2020
Abstract Thirty years of rapid technological advances in the field of genetic testing and assisted reproduction have reshaped the procedure of preimplantation genetic testing (PGT). The development of whole genome amplification and genome-wide testing tools together with the implementation of optimal hormonal stimulation protocols and
Martine, De Rycke, Veerle, Berckmoes, Anick, De Vos, Stefanie, Van De Voorde, Pieter, Verdyck, Willem, Verpoest, Kathelijn, Keymolen   +6 more
openaire   +2 more sources

Temporal Evaluation of a Minimally Invasive Method of Preimplantation Genetic Testing for Aneuploidy (mi-PGT-A) in Human Embryos

Reproductive Medicine
Preimplantation genetic testing for aneuploidy (PGT-A) has become a useful approach for embryo selection following IVF and ICSI. However, the biopsy process associated with PGT-A is expensive, prone to errors in embryo ploidy determination, and ...
Katharine R. B. Phillips, Alexander G. Kuzma-Hunt, Michael S. Neal, Connie Lisle, Hariharan Sribalachandran, Ronald F. Carter, Shilpa Amin, Megan F. Karnis, Mehrnoosh Faghih   +8 more
doaj   +1 more source

Transcriptome profiling of human pre-implantation development. [PDF]

PLoS ONE, 2009
BACKGROUND: Preimplantation development is a crucial step in early human development. However, the molecular basis of human preimplantation development is not well known.
Pu Zhang, Marco Zucchelli, Sara Bruce, Fredwell Hambiliki, Anneli Stavreus-Evers, Lev Levkov, Heli Skottman, Erja Kerkelä, Juha Kere, Outi Hovatta   +9 more
doaj   +1 more source

A rhesus macaque model of α‐dystroglycanopathy caused by a POMT1 splice altering variant

Animal Models and Experimental Medicine, EarlyView.
Rhesus macaques homozygous for a naturally occurring spice altering variant in the POMT1 gene develop lissencephaly, microphthalmia, and muscular contracture. The presentation models severe presentation of the human Walker‐Warburg syndrome. Abstract Background Biallelic mutations in genes associated with α‐dystroglycan glycosylation manifest in a ...
Anya Nordlund, Brian LaMendola, Nathan P. Crilly, Seth Kittle, Betsy M. Ferguson, Anne D. Lewis, Jeff Wall, Samuel M. Peterson   +7 more
wiley   +1 more source

Research progress on the role of histone acetylation regulatory factors during the early embryonic development in animals

浙江大学学报. 农业与生命科学版
Following sperm-egg fusion, animal embryos undergo severe epigenetic reprogramming during the early development, encompassing DNA methylation, histone modification, as well as chromatin remodeling, to ensure that highly differentiated gametes form ...
LI Xiaoteng, ZHAO Panpan, ZHANG Kun
doaj   +1 more source

Does stereoelectroencephalographic depth electrode insertion alter seizure frequency? A baseline versus endpoint analysis

Epilepsia, EarlyView.
Abstract The implantation effect refers to a transient reduction in seizure frequency following intracranial electrode insertion in patients with epilepsy, independent of therapeutic intervention. This retrospective study examined potential clinical and demographic predictors of the implantation effect in 51 patients who underwent ...
Shreyashish Roy‐Chowdhury, Jorge G. Burneo, Juan Toro‐Perez, David A. Steven, Michelle Lee‐Jones, Keith MacDougall, Jonathan Lau, Richard S. McLachlan, Ana Suller Marti   +8 more
wiley   +1 more source

Preimplantation Diagnosis of Thalassemias [PDF]

Journal of Assisted Reproduction and Genetics, 1998
Preimplantation genetic diagnosis (PGD) is an important option for couples at risk of having children with beta-globin mutations to avoid selective abortions of affected fetuses following prenatal diagnosis.We performed PGD for thalassemia in 12 clinical cycles (IVS1-110, and IVS-745 mutations) using biopsy of the first and second polar bodies (PBs ...
A, Kuliev, S, Rechitsky, O, Verlinsky, V, Ivakhnenko, S, Evsikov, G, Wolf, M, Angastiniotis, D, Georghiou, V, Kukharenko, C, Strom, Y, Verlinsky   +10 more
openaire   +2 more sources

Comparative multicenter evaluation of thalamic neuromodulation for treatment‐resistant epilepsy in children

Epilepsia, EarlyView.
Abstract Objective Use of neuromodulation strategies targeting thalamic nuclei, including deep brain stimulation (DBS) and responsive neurostimulation (RNS), for treatment of pediatric drug‐resistant epilepsy (DRE) is increasing, despite limited evidence for efficacy and safety. We present the initial results from the Comparative Multicenter Evaluation
Samuel A. Tenhoeve, Nebras M. Warsi, Allison M. Ludwick, Adam C. Glaser, Marcella R. Ruppert‐Gomez, Scellig S. Stone, Megan Votoupal, Jeffrey S. Raskin, Shanique Doyle, Benjamin Kennedy, Deborah Grenard, Dominic Nistal, Hannah E. Goldstein, Jason S. Hauptman, Gavin Yoon, Kurtis I. Auguste, David D. Gonda, Alon Kashanian, Shaun D. Rodgers, Janette Coble, Jarod L. Roland, Nunthasiri Wittayanakorn, Chima O. Oluigbo, Somnath Das, Jasmine A. Thum, Carolina Gorodetsky, MyLoi Huynh, George M. Ibrahim, Robert J. Bollo   +28 more
wiley   +1 more source

Ethical attitudes of German specialists in reproductive medicine and legal regulation of preimplantation sex selection in Germany. [PDF]

PLoS ONE, 2013
BACKGROUND: Because of its ethical and social implications, preimplantation sex selection is frequently the subject of debates. METHODS: In 2006, we surveyed specialists in reproductive medicine in Germany using an anonymous questionnaire, including ...
Miriam Wilhelm, Edgar Dahl, Henry Alexander, Elmar Brähler, Yve Stöbel-Richter   +4 more
doaj   +1 more source