Results 1 to 10 of about 74,435 (263)
Primary cilia in neurodevelopmental disorders [PDF]
Nature Reviews Neurology, 2013 Primary cilia are generally solitary organelles that emanate from the surface of almost all vertebrate cell types. Until recently, details regarding the function of these structures were lacking; however, extensive evidence now suggests that primary cilia have critical roles in sensing the extracellular environment, and in coordinating developmental ...
Enza Maria Valente, Joseph G Gleeson
exaly +5 more sources
Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd2 [PDF]
Science, 2012 Unidirectional fluid flow plays an essential role in the breaking of left-right (L-R) symmetry in mouse embryos, but it has remained unclear how the flow is sensed by the embryo.
Kyosuke Shinohara +2 more
exaly +3 more sources
Primary Cilia and Atherosclerosis [PDF]
Frontiers in Physiology, 2021 In artery tree, endothelial function correlates with the distribution of shear stress, a dragging force generated by flowing blood. In laminar shear stress areas, endothelial cells (ECs) are available to prevent atherosclerosis, however, ECs in disturbed shear stress sites are featured with proinflammation and atherogenesis.
Zhi-Mei Wang +3 more
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Current Osteoporosis Reports, 2023 Abstract Purpose of Review The purpose of this review is to provide a background on osteocytes and the primary cilium, discussing the role it plays in osteocyte mechanosensing. Recent Findings Osteocytes are thought to be the primary mechanosensing cells in bone tissue ...
Verbruggen, S.W. +2 more
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Assembly of primary cilia [PDF]
Developmental Dynamics, 2008 AbstractPrimary cilia are microtubule‐based, hair‐like sensory organelles present on the surface of most growth‐arrested cells in our body. Recent research has demonstrated a crucial role for primary cilia in regulating vertebrate developmental pathways and tissue homeostasis, and defects in genes involved in primary cilia assembly or function have ...
Pedersen, Lotte B +3 more
openaire +4 more sources
Visualizing renal primary cilia [PDF]
Nephrology, 2013 AbstractRenal primary cilia are microscopic sensory organelles found on the apical surface of epithelial cells of the nephron and collecting duct. They are based upon a microtubular cytoskeleton, bounded by a specialized membrane, and contain an array of proteins that facilitate their assembly, maintenance and function.
Deane, James +7 more
openaire +3 more sources
Rab7 regulates primary cilia disassembly through cilia excision [PDF]
Journal of Cell Biology, 2019 The primary cilium is a sensory organelle that protrudes from the cell surface. Primary cilia undergo dynamic transitions between assembly and disassembly to exert their function in cell signaling. In this study, we identify the small GTPase Rab7 as a novel regulator of cilia disassembly.
Guang Wang +17 more
openaire +2 more sources
Calcium channels in primary cilia [PDF]
Current Opinion in Nephrology and Hypertension, 2016 Primary cilia have become important organelles implicated in embryonic development, organogenesis, health, and diseases. Although many studies in cell biology have focused on changes in ciliary length or ciliogenesis, the most common readout for evaluating ciliary function is intracellular calcium.Recent tools have allowed us to examine intracellular ...
Surya M, Nauli +2 more
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Primary cilia and lipid raft dynamics [PDF]
Open Biology, 2021 Primary cilia, antenna-like structures of the plasma membrane, detect various extracellular cues and transduce signals into the cell to regulate a wide range of functions. Lipid rafts, plasma membrane microdomains enriched in cholesterol, sphingolipids and specific proteins, are also signalling hubs involved in a myriad of physiological functions ...
Yuhei Nishimura +5 more
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Quiescent melanocytes form primary cilia [PDF]
Experimental Dermatology, 2014 AbstractWe show, for the first time, that melanocytes can form a primary cilium in vitro, corresponding to an immotile or sensory cilium. Such cilia are observed when melanocytes reach confluence or when medium nutrient levels are insufficient. This observation should greatly improve our understanding of the signal transduction processes potentially ...
Madeleine, Le Coz +2 more
openaire +2 more sources