Primary cilia and lipid raft dynamics [PDF]
Open Biology, 2021 Primary cilia, antenna-like structures of the plasma membrane, detect various extracellular cues and transduce signals into the cell to regulate a wide range of functions.
Yuhei Nishimura +5 more
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Primary cilia in the mature brain: emerging roles in Alzheimer’s disease pathogenesis [PDF]
Frontiers in Cell and Developmental BiologyPrimary cilia are microtubule-based structures that resemble antennae and function as sensory organelles. Dysfunction of primary cilia has been linked to various age-related conditions.
Alexis Shiying Huang +3 more
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Rediscovering Primary Cilia in Pancreatic Islets [PDF]
Diabetes & Metabolism Journal, 2023 Primary cilia are microtubule-based sensory and signaling organelles on the surfaces of most eukaryotic cells. Despite their early description by microscopy studies, islet cilia had not been examined in the functional context until recent decades.
Eun Young Lee, Jing W. Hughes
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Primary cilia in neurodevelopmental disorders [PDF]
Nature Reviews Neurology, 2013 Primary cilia are generally solitary organelles that emanate from the surface of almost all vertebrate cell types. Until recently, details regarding the function of these structures were lacking; however, extensive evidence now suggests that primary cilia have critical roles in sensing the extracellular environment, and in coordinating developmental ...
Enza Maria Valente, Joseph G Gleeson
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Lengthening primary cilia enhances cellular mechanosensitivity [PDF]
European Cells & Materials, 2017 The primary cilium is a mechanosensor in a variety of mammalian cell types, initiating and directing intracellular signalling cascades in response to external stimuli.
M Spasic, CR Jacobs
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Primary cilia in cancer: structures, functions, mechanisms, and therapeutic implications [PDF]
Cancer Biology & MedicinePrimary cilia, microtubule-based organelles protruding from the surfaces of most eukaryotic cells, have critical roles in maintaining cellular homeostasis, by sensing, transducing, and transmitting diverse extracellular and intracellular signals through ...
Miaomiao Zheng, Jun Zhou, Yijie Wang
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CU Cilia – an application for image analysis by machine learning – reveals significance of cysteine cathepsin K activity for primary cilia of human thyroid epithelial cells [PDF]
Frontiers in EndocrinologyIntroductionCysteine cathepsins K and L are crucial for proper thyroid function in mice. Inhibition of cysteine peptidases in rodent thyroid epithelial cells in vitro results in loss of primary cilia, highlighting the significance of proteolysis for ...
Maren Rehders +8 more
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Application of bioactive materials primary cilia as a novel delivery vehicle [PDF]
Bioactive MaterialsPrimary cilia are hair-like structured cell organelles functioning as cellular antennae with chemosensory and mechanosensory roles. Dysfunction of cilia results in ciliopathies, including renovascular diseases (polycystic kidneys, hypertension, aneurysm),
Ayan K. Barui +7 more
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Growth factor-independent mTORC1 signaling promotes primary cilia length via suppression of autophagy [PDF]
iScienceSummary: The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1), a sensor of growth signals that control cell growth, has been studied mainly in proliferating cells.
Jong Shin +9 more
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Primary cilia in growth plates orchestrate long bone development [PDF]
Fundamental ResearchThe growth plate plays a crucial role in long bone development and elongation, housing stem cells that contribute to bone formation. This study investigates the role of primary cilia, specialized organelles that regulate stem cell fate, in the ...
Lei Zhang +8 more
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