Results 141 to 150 of about 16,662 (259)

NOTCH3 CADASIL Variant Receptor Aggregation Requires NOTCH3 Wild‐Type Receptors: Identification of Highly Selective Inhibitors That Block the Process

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
CADASIL is the major cause of early‐onset stroke and cognitive dysfunction, including dementia. It is caused by mutations in the NOTCH3 receptor that result in the formation of protein aggregates in the small vessel walls of the brain. We demonstrated that NOTCH3 CADASIL variant receptor aggregation is strictly dependent on interactions with NOTCH3 ...
Haijiang Wang, Xinxin Liu, Gido Gravesteijn, Alessia Atella, Jin Liu, Julie W. Rutten, Peter ten Dijke, Manuel A. F. V. Gonçalves, Saskia A. J. Lesnik Oberstein, David A. Baker   +9 more
wiley   +1 more source

Doppel as an early‐stage biomarker promoting EMT and dissemination in ovarian cancers

International Journal of Cancer, Volume 158, Issue 6, Page 1755-1768, 15 March 2026.
What's new? Existing biomarkers for ovarian cancer (OC) lack the sensitivity and specificity needed to consistently distinguish the malignancy from non‐ovarian influences and other cancers. Here, the authors explored the ability of the prion‐like protein Doppel, normally found in the male testes, to detect OC.
Zulfikar Azam, Xiaojun Zhang, Riajul Wahab, Md Mahedi Hasan, Shivaniben Dhadhal, Bowon Kang, Md Mynul Hassan, Mazharul Karim, Jeong Uk Choi, Muhit Rana, Jian‐Ying Zhang, Sourav Roy, Youngro Byun, In‐San Kim, Jae Yun Song, Eugene P. Toy, Sireesha Y. Reddy, Farzana Alam, Taslim A. Al‐Hilal   +18 more
wiley   +1 more source

Antimicrobial and Cytotoxic Activities of Biogenic Nanoparticles Produced by Cyanobacteria

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
The article reviews the green synthesis of biogenic nanoparticles produced by cyanobacteria, highlighting their antimicrobial and cytotoxic properties. These nanoparticles, formed intra‐ or extracellularly, show activity against Gram‐positive and Gram‐negative bacteria as well as fungi and can induce apoptosis in tumor cells.
Laíne Santos Ribeiro, Rhuana Valdetário Médice, Janaína Morone Bavini, Camila Manoel Crnkovic, Samuel Cavalcante do Amaral   +4 more
wiley   +1 more source

Clinical perspectives of emerging pathogens in bleeding disorders. [PDF]

, 2006
As a result of immunological and nucleic-acid screening of plasma donations for transfusion-transmissible viruses, and the incorporation of viral reduction processes during plasma fractionation, coagulation-factor concentrates (CFC) are now judged safe ...
Bozzette, Samuel, Diamond, Michael, Koerper, Marion A, Kulkarni, Roshni, Ludlam, Christopher A, Powderly, William G, Ritchie, Bruce, Siegel, Jamie, Simmonds, Peter, Stanley, Samuel, Tapper, Michael L, von Depka, Mario   +11 more
core   +1 more source

Catalytic Amyloids: Turning Fibrils Into Biocatalysts

Chemistry – A European Journal, Volume 32, Issue 10, 9 March 2026.
Amyloids, traditionally associated with diseases, have emerged as versatile catalytic scaffolds. From natural amyloid sequences to bioinspired and de novo designs, we highlight strategies to construct catalytic active sites and anchor enzymes onto fibrils, creating versatile nanomaterials with tunable activities. ABSTRACT Amyloids have been regarded as
Alessandra Esposito, Linda Leone, Flavia Nastri, Angela Lombardi   +3 more
wiley   +1 more source

Desmin forms toxic, seeding-competent amyloid aggregates that persist in muscle fibers [PDF]

, 2019
Desmin-associated myofibrillar myopathy (MFM) has pathologic similarities to neurodegeneration-associated protein aggregate diseases. Desmin is an abundant muscle-specific intermediate filament, and disease mutations lead to its aggregation in cells ...
Arhzaouy, Khalid, Batchelor, Mark, Bieschke, Jan, Kedia, Niraja, Pittman, Sara K., Sun, Yuanzi, Weihl, Conrad C.   +6 more
core   +1 more source

Increased incidence of mild cognitive impairment in long COVID patients

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Though brain fog is common in Long‐coronavirus disease 2019 (Long‐COVID), the incidence of mild cognitive impairment (MCI) is unknown. METHODS In an observational cohort study, recovered COVID‐positive, Long‐COVID, and COVID‐negative subjects underwent blinded evaluation using National Alzheimer's Coordinating Center (NACC) and ...
Jennifer A. Frontera, Arjun V. Masurkar, Rebecca A. Betensky, Zariya Alvarez, Allal Boutajangout, Joshua Chodosh, Salma Hammam, Jessica Hunter, Li Jiang, Melanie Li, Jon Links, Karyn Marsh, Huize Pang, Floyd Silva, Sujata Thawani, Daria Vasilchenko, Alok Vedvyas, Amin Yakubov, Yulin Ge, Thomas Wisniewski   +19 more
wiley   +1 more source

Fractional Order Epidemic System of Saturated Rate of Incidence: A Neural Network Approach

Engineering Reports, Volume 8, Issue 3, March 2026.
The workflow depictions of the mathematical fractional order saturated rate of incidence model using the process of Levenberg–Marquardt Backpropagation neural network. The designed neural network contains 20 numbers of neurons, a sigmoid activation function, and a single hidden layer structure.
Zulqurnain Sabir, M. A. Abdelkawy, Muhammad Umar, Soheil Salahshour   +3 more
wiley   +1 more source

Repeated Episodes of GPP Induced by Respiratory Infections Are Mediated by Loss‐of‐Function IFIH1

Immunity, Inflammation and Disease, Volume 14, Issue 3, March 2026.
ABSTRACT Background Generalized pustular psoriasis (GPP) is a severe and recurrent autoinflammatory disease that can be induced by a variety of factors. At present, its etiology and pathogenesis have not yet been fully elucidated. Upper respiratory tract infections are the main predisposing factor in children with GPP, and the MDA5 protein encoded by ...
Yaqin Liu, Yanan Sun, Juan Yang, Hongmei Li, Weihui Zhou, Shasha Meng   +5 more
wiley   +1 more source

Plasmonics‐Enhanced Characterization of Cervid PrP (87–114) Fragment Aggregates in Solution

Journal of Biophotonics, Volume 19, Issue 3, March 2026.
Multimodal nanophotonics platform combining plasmon‐enhanced imaging, label‐free SERS, and optical staining reveals new insights into the aggregation of the cervid PrP (87–114) fragment, an amyloidogenic sequence linked to chronic wasting disease susceptibility.ABSTRACTWe performed a multimodal characterisation of self‐assembled fibrillar aggregates ...
Shinki Midha, Aishwarya Sriraman, Lyudmyla Dorosh, Holger Wille, Maria Stepanova   +4 more
wiley   +1 more source