Results 81 to 90 of about 16,662 (259)

Enhanced Sensitivity of a Modified Quaking‐Induced Conversion Diagnostic Test for the Broad Detection of Sporadic and Inherited Prion Diseases: A Retrospective Study

Annals of Neurology, EarlyView.
Objective Quaking‐induced conversion (QuIC) tests, which detect prion‐seeding activity in cerebrospinal fluid (CSF), have markedly advanced the antemortem diagnosis of prion diseases such as Creutzfeldt‐Jakob disease (CJD). These tests provide high diagnostic accuracy and enable timely differentiation from other rapidly progressive neurodegenerative ...
Jennifer Myskiw, Rebecca Fox, Dominic M.S. Kielich, Lise Lamoureux, Melanie Leonhardt, Olivia Nykvist, Jessy A. Slota, Kristen Avery, Clark Phillipson, Kathy Frost, Sharon Simon, Brian S. Appleby, Ben A. Bailey‐Elkin, Stephanie A. Booth   +13 more
wiley   +1 more source

Cadaveric Human Growth Hormone–Associated Creutzfeldt-Jakob Disease with Long Latency Period, United States

Emerging Infectious Diseases
We report a case of iatrogenic Creutzfeldt-Jakob disease (iCJD) after a 48.3-year incubation period in a patient treated with cadaveric human growth hormone.
Anatevka S. Ribeiro, Andrew B. Wolf, Ellen W. Leschek, Lawrence B. Schonberger, Joseph Y. Abrams, Ryan A. Maddox, Brian S. Appleby, Katie Glisic, Aaron Carlson, Elizabeth Matthews   +9 more
doaj   +1 more source

Diagnosis of Methionine/Valine Variant Creutzfeldt-Jakob Disease by Protein Misfolding Cyclic Amplification

Emerging Infectious Diseases, 2018
A patient with a heterozygous variant of Creutzfeldt-Jakob disease (CJD) with a methionine/valine genotype at codon 129 of the prion protein gene was recently reported.
Daisy Bougard, Maxime Bélondrade, Charly Mayran, Lilian Bruyère-Ostells, Sylvain Lehmann, Chantal Fournier-Wirth, Richard S. Knight, Robert G. Will, Alison J.E. Green   +8 more
doaj   +1 more source

Emerging and emerging common diseases in Iraq [PDF]

Iraqi Journal of Veterinary Sciences, 2009
Zoonoses are among the most common forms of disease in nature. Surveys have shown that 816 of 1,407 (58%) human pathogens, including 208 viruses and prions, 538 bacteria and worms, and 317 helminthes, were zoonotic in origin, meaning they could be ...
Dhia Muhammad Taher1 and Darem Tabbaa2
doaj   +1 more source

"Alternative" endocytic mechanisms exploited by pathogens: new avenues for therapeutic delivery? [PDF]

, 2007
Some pathogens utilize unique routes to enter cells that may evade the intracellular barriers encountered by the typical clathrin-mediated endocytic pathway.
Medina-Kauwe, LK
core   +1 more source

ER stress signaling and neurodegeneration: At the intersection between Alzheimer's disease and Prion-related disorders

Virus Research, 2015
Alzheimer's and Prion diseases are two neurodegenerative conditions sharing different pathophysiological characteristics. Disease symptoms are associated with the abnormal accumulation of protein aggregates, which are generated by the misfolding and oligomerization of specific proteins.
Torres, Mauricio, Matamala, José Manuel, Durán Aniotz, Claudia, Cornejo, Víctor Hugo, Foley, Andrew, Hetz Flores, Claudio   +5 more
openaire   +3 more sources

Analysis of Single Particles of Amyloid Beta and α‐Synuclein With Seeded Amplification for the Diagnosis of Alzheimer's and Parkinson's Disease

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by the pathological aggregation of specific proteins such as amyloid beta (Aβ) and α‐synuclein, respectively. Early detection of these protein aggregates in biological fluids could facilitate timely diagnosis and therapeutic ...
Alexandra Dybala, Marlene Pils, Oliver Bannach, Gültekin Tamgüney, Detlev Riesner   +4 more
wiley   +1 more source

Dysregulation of neuroprotective astrocytes, a spectrum of microglial activation states, and altered hippocampal neurogenesis are revealed by single-cell RNA sequencing in prion disease

Acta Neuropathologica Communications, 2022
Prion diseases are neurodegenerative disorders with long asymptomatic incubation periods, followed by a rapid progression of cognitive and functional decline culminating in death.
Jessy A. Slota, Babu V. Sajesh, Kathy F. Frost, Sarah J. Medina, Stephanie A. Booth   +4 more
doaj   +1 more source

On the statistical mechanics of prion diseases

, 2001
We simulate a two-dimensional, lattice based, protein-level statistical mechanical model for prion diseases (e.g., Mad Cow disease) with concommitant prion protein misfolding and aggregation.
A. Coghlan, A. Slepoy, C. I. Lasmézas, D. J. Stekel, D. L. Cox, D. O. V. Alonso, F. Pázmándi, H. Rudyk, J. H. Come, J. Masel, J. N. Onuchic, J. S. Griffith, K. Post, M. A. Nowak, M. Beekes, M. Eigen, M. Horiuchi, M. Horiuchi, M. Laurent, R. Demaimay, R. M. Anderson, R. R. P. Singh, R. V. Kulkarni, S. B. Prusiner, T. R. Serio, W. Swietnicki   +25 more
core   +1 more source

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, EarlyView.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source