Results 11 to 20 of about 188,968 (306)

A Prognostic Gene Signature for Hepatocellular Carcinoma

Frontiers in Oncology, 2022
Hepatocellular carcinoma is the third most common cause of cancer-related deaths in China and immune-based therapy can improve patient outcomes. In this study, we investigated the relationship between immunity-associated genes and hepatocellular carcinoma from the prognostic perspective.
Rong Chen, Meng Zhao, Yanli An, Yanli An, Dongfang Liu, Qiusha Tang, Gaojun Teng   +6 more
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Prognostic Alternative Splicing Signatures in Esophageal Carcinoma

Cancer Management and Research, 2021
Alternative splicing (AS) is a method of increasing the number of proteins that the genome is capable of coding for, by altering the pre-mRNA during its maturation. This process provides the ability of a broad range of proteins to arise from a single gene. AS events are known to occur in up to 94% of human genes.
Zodwa Dlamini, Rodney Hull, Sikhumbuzo Z Mbatha, Mohammed Alaouna, You-Lin Qiao, Herbert Yu, Aristotelis Chatziioannou   +6 more
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Development of Autophagy Signature‐Based Prognostic Nomogram for Refined Glioma Survival Prognostication [PDF]

BioMed Research International, 2020
The current glioma classification could be optimized to cover such a separate and individualized prognosis ranging from a few months to over ten years. Considering its highly conserved role and potential in therapies, autophagy might be a promising element to be incorporated as a refinement for improved survival prognostication.
Yuxiang Fan, Xinyu Peng, Baoqin Li, Gang Zhao   +3 more
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Prostate cancer genomic signature offers prognostic value [PDF]

Cancer Biology & Therapy, 2010
Previous attempts to link prostate cancer progression to genetic alterations have been unsuccessful, and consequently, there is still no reliable predictor of prognosis for men with this disease. A recent study by Taylor et al., published in Cancer Cell, assesses copy number alterations, mutations, and transcriptomes in 218 tumors and 12 prostate ...
Sarah M, Troutman, Douglas K, Price, William D, Figg   +2 more
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Prognostic stromal gene signatures in breast cancer [PDF]

Breast Cancer Research, 2015
Abstract Introduction Global gene expression analysis of tumor samples has been a valuable tool to subgroup tumors and has the potential to be of prognostic and predictive value. However, tumors are heterogeneous, and homogenates will consist of several different cell types.
Winslow, Sofia, Leandersson, Karin, Edsjö, Anders, Larsson, Christer   +3 more
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Macrophages M1-Related Prognostic Signature in Hepatocellular Carcinoma [PDF]

Journal of Oncology, 2021
A large number of studies have found that macrophages M1 play an important role in the occurrence and development of tumors. The aim of our study is to explore the causes of differential infiltration of macrophages M1 in hepatocellular carcinoma from the perspective of transcriptome and establish a prognostic model of hepatocellular carcinoma.
Hao Zhang, Lin Sun, Xiao Hu
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A novel prognostic six‐CpG signature in glioblastomas [PDF]

CNS Neuroscience & Therapeutics, 2018
SummaryAimsWe aimed to identify a clinically useful biomarker using DNA methylation‐based information to optimize individual treatment of patients with glioblastoma (GBM).MethodsA six‐CpG panel was identified by incorporating genome‐wide DNA methylation data and clinical information of three distinct discovery sets and was combined using a risk‐score ...
Yin, An-An, Lu, Nan, Etcheverry, Amandine, Aubry, Marc, Barnholtz-Sloan, Jill, Zhang, Lu-Hua, Mosser, Jean, Zhang, Wei, Zhang, Xiang, Liu, Yu-He, He, Ya-Long   +10 more
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Significance Analysis of Prognostic Signatures

PLoS Computational Biology, 2013
A major goal in translational cancer research is to identify biological signatures driving cancer progression and metastasis. A common technique applied in genomics research is to cluster patients using gene expression data from a candidate prognostic gene set, and if the resulting clusters show statistically significant outcome stratification, to ...
Beck, Andrew, Knoblauch, Nicholas W., Hefti, Marco, Kaplan, Jennifer, Schnitt, Stuart, Culhane, Aedin, Schroeder, Markus S., Risch, Thomas, Quackenbush, John, Haibe-Kains, Benjamin   +9 more
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Whole transcriptome signature for prognostic prediction (WTSPP): application of whole transcriptome signature for prognostic prediction in cancer

Laboratory Investigation, 2020
Developing prognostic biomarkers for specific cancer types that accurately predict patient survival is increasingly important in clinical research and practice. Despite the enormous potential of prognostic signatures, proposed models have found limited implementations in routine clinical practice.
Schaafsma, Evelien, Zhao, Yanding, Wang, Yue, Varn, Frederick S., Zhu, Kenneth, Yang, Huan, Cheng, Chao   +6 more
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Apoptosis-related genes-based prognostic signature for osteosarcoma

Aging, 2022
Osteosarcoma (OS) is a common malignant primary tumor of skeleton, especially in children and adolescents, characterized by high lung metastasis rate. Apoptosis has been studied in various tumors, while the prognostic role of apoptosis-related genes in OS has been seldom studied.
Yang, Fei, Zhang, Yi
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