Results 11 to 20 of about 187,404 (263)

Significance Analysis of Prognostic Signatures

PLoS Computational Biology, 2013
A major goal in translational cancer research is to identify biological signatures driving cancer progression and metastasis. A common technique applied in genomics research is to cluster patients using gene expression data from a candidate prognostic gene set, and if the resulting clusters show statistically significant outcome stratification, to ...
Beck, Andrew, Knoblauch, Nicholas W., Hefti, Marco, Kaplan, Jennifer, Schnitt, Stuart, Culhane, Aedin, Schroeder, Markus S., Risch, Thomas, Quackenbush, John, Haibe-Kains, Benjamin   +9 more
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KRAS driven expression signature has prognostic power superior to mutation status in non-small cell lung cancer [PDF]

, 2017
KRAS is the most frequently mutated oncogene in non-small cell lung cancer (NSCLC). However, the prognostic role of KRAS mutation status in NSCLC still remains controversial.
Alamgeer, Anders, Andreyev, Belani, Ben-Neriah, Boolell, Cancer Genome Atlas, Cancer Genome Atlas Research N, Cancer Genome Atlas Research N, Cappuzzo, Cibulskis, Cingolani, Colicelli, Davies, Ettinger, Forbes, Georgoulias, Greuber, Gyorffy, Gyorffy, Gyorffy, Hunter, Janne, Karnoub, Kwak, Li, Mao, Massarelli, Meng, Meng, Mok, Ogino, Paez, Patterson, Pongor, Riely, Scoccianti, Shaw, Shigematsu, Siegel, Sos, Takahashi, Vasan, Zardavas, Zhou   +44 more
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Lost in translation—prognostic signatures for breast cancer [PDF]

Nature Clinical Practice Oncology, 2008
Lajos Pusztai
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A Novel Immune-Related Prognostic Signature for Thyroid Carcinoma [PDF]

Technology in Cancer Research & Treatment, 2020
Background: Recent studies have confirmed that immune-associated genes perform a crucial function in recurrence and metastasis of thyroid carcinoma. A reliable immune-related prognostic signature for patients with thyroid cancer is needed.
Yuanbo Xue MD, Jing Li MD, Xiubo Lu MD
doaj   +3 more sources

A Prognostic Gene Signature for Hepatocellular Carcinoma

Frontiers in Oncology, 2022
Hepatocellular carcinoma is the third most common cause of cancer-related deaths in China and immune-based therapy can improve patient outcomes. In this study, we investigated the relationship between immunity-associated genes and hepatocellular carcinoma from the prognostic perspective.
Rong Chen, Meng Zhao, Yanli An, Yanli An, Dongfang Liu, Qiusha Tang, Gaojun Teng   +6 more
openaire   +3 more sources

Establishment and Validation of a Prognostic Immune Signature in Neuroblastoma [PDF]

Cancer Control, 2021
Background Neuroblastoma (NBL) is the most common extracranial solid tumor in childhood, and patients with high-risk neuroblastoma had a relatively poor prognosis despite multimodal treatment. To improve immunotherapy efficacy in neuroblastoma, systematic profiling of the immune landscape in neuroblastoma is an urgent need.
Yunhu Yu, Yu Zeng, Xiangping Xia, Jian-Guo Zhou, Fang Cao   +4 more
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Identifying prognostic signatures in the microenvironment of prostate cancer [PDF]

Translational Andrology and Urology, 2021
An increasing number of studies has indicated that the tumor microenvironment (TME), an important component of tumor tissue, has clinicopathological significance in predicting disease outcome and therapeutic efficacy. However, little evidence in prostate cancer (PCa) is available.The cohort of TCGA-PRAD (n=477) was used in this study.
Weijing Cai, Dawei Wang, Bao-Xing Huang, Xiaojing Wang, Guoliang Lu, Yang Zhao, Yuan Shao   +6 more
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Prognostic Alternative Splicing Signatures in Esophageal Carcinoma

Cancer Management and Research, 2021
Alternative splicing (AS) is a method of increasing the number of proteins that the genome is capable of coding for, by altering the pre-mRNA during its maturation. This process provides the ability of a broad range of proteins to arise from a single gene. AS events are known to occur in up to 94% of human genes.
Herbert Yu, Herbert Yu, Zodwa Dlamini, Mohammed Alaouna, Mohammed Alaouna, Sikhumbuzo Mbatha, You-Lin Qiao, You-Lin Qiao, Rodney Hull, Aristotelis Chatziioannou, Aristotelis Chatziioannou   +10 more
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An individualized immune prognostic signature in lung adenocarcinoma [PDF]

Cancer Cell International, 2020
AbstractBackgroundTumor immune infiltration is closely associated with clinical outcome in lung cancer. We aimed to develop an immune signature to improve the prognostic predictions of lung adenocarcinoma (LUAD).MethodsWe applied “Cell type Identification by Estimating Relative Subsets of RNA Transcripts” method to quantify the fraction of 22 leukocyte
Liangdong Sun, Gening Jiang, Diego Gonzalez-Rivas, Peng Zhang   +3 more
openaire   +4 more sources

Prognostic stromal gene signatures in breast cancer [PDF]

Breast Cancer Research, 2015
Abstract Introduction Global gene expression analysis of tumor samples has been a valuable tool to subgroup tumors and has the potential to be of prognostic and predictive value. However, tumors are heterogeneous, and homogenates will consist of several different cell types.
Winslow, Sofia, Leandersson, Karin, Edsjö, Anders, Larsson, Christer   +3 more
openaire   +5 more sources