Results 11 to 20 of about 125,185 (173)

Construction and Validation of Novel Diagnostic and Prognostic DNA Methylation Signatures for Hepatocellular Carcinoma

Frontiers in Genetics, 2020
Hepatocellular carcinoma (HCC) is one of the most prevalent life-threatening human cancers and the leading cause of cancer-related mortality, with increased global incidence within the last decade.
Ran Li, Liyan Shui, Junling Jia, Junling Jia, Chao Wu   +4 more
doaj   +1 more source

Prognostic Alternative Splicing Signatures in Esophageal Carcinoma

Cancer Management and Research, 2021
Alternative splicing (AS) is a method of increasing the number of proteins that the genome is capable of coding for, by altering the pre-mRNA during its maturation. This process provides the ability of a broad range of proteins to arise from a single gene. AS events are known to occur in up to 94% of human genes.
Herbert Yu, Herbert Yu, Zodwa Dlamini, Mohammed Alaouna, Mohammed Alaouna, Sikhumbuzo Mbatha, You-Lin Qiao, You-Lin Qiao, Rodney Hull, Aristotelis Chatziioannou, Aristotelis Chatziioannou   +10 more
openaire   +6 more sources

An individualized immune prognostic signature in lung adenocarcinoma [PDF]

Cancer Cell International, 2020
AbstractBackgroundTumor immune infiltration is closely associated with clinical outcome in lung cancer. We aimed to develop an immune signature to improve the prognostic predictions of lung adenocarcinoma (LUAD).MethodsWe applied “Cell type Identification by Estimating Relative Subsets of RNA Transcripts” method to quantify the fraction of 22 leukocyte
Liangdong Sun, Gening Jiang, Diego Gonzalez-Rivas, Peng Zhang   +3 more
openaire   +4 more sources

A seven-gene prognostic signature predicts overall survival of patients with lung adenocarcinoma (LUAD)

Cancer Cell International, 2021
Background Lung adenocarcinoma (LUAD) is one of the most common types in the world with a high mortality rate. Despite advances in treatment strategies, the overall survival (OS) remains short.
Aisha Al-Dherasi, Qi-Tian Huang, Yuwei Liao, Sultan Al-Mosaib, Rulin Hua, Yichen Wang, Ying Yu, Yu Zhang, Xuehong Zhang, Chao Huang, Haithm Mousa, Dongcen Ge, Sufiyan Sufiyan, Wanting Bai, Ruimei Liu, Yanyan Shao, Yulong Li, Jingkai Zhang, Leming Shi, Dekang Lv, Zhiguang Li, Quentin Liu   +21 more
doaj   +1 more source

Development of a novel glycolysis-related genes signature for isocitrate dehydrogenase 1-associated glioblastoma multiforme

Frontiers in Immunology, 2022
BackgroundThe significant difference in prognosis between IDH1 wild-type and IDH1 mutant glioblastoma multiforme (GBM) may be attributed to their metabolic discrepancies. Hence, we try to construct a prognostic signature based on glycolysis-related genes
Xiaomin Cai, Zheng Chen, Caiquan Huang, Jie Shen, Wenxian Zeng, Shuang Feng, Yu Liu, Shiting Li, Ming Chen   +8 more
doaj   +1 more source

Prediction of 5-year Progression-Free Survival in Advanced Nasopharyngeal Carcinoma with Pretreatment PET/CT using Multi-Modality Deep Learning-based Radiomics [PDF]

Frontiers in Oncology, vol. 12, pp. 899352, 2022, 2021
Objective: Deep Learning-based Radiomics (DLR) has achieved great success in medical image analysis and has been considered a replacement for conventional radiomics that relies on handcrafted features. In this study, we aimed to explore the capability of DLR for the prediction of 5-year Progression-Free Survival (PFS) in Nasopharyngeal Carcinoma (NPC ...
arxiv   +1 more source

Prognostic stromal gene signatures in breast cancer [PDF]

Breast Cancer Research, 2015
Abstract Introduction Global gene expression analysis of tumor samples has been a valuable tool to subgroup tumors and has the potential to be of prognostic and predictive value. However, tumors are heterogeneous, and homogenates will consist of several different cell types.
Winslow, Sofia, Leandersson, Karin, Edsjö, Anders, Larsson, Christer   +3 more
openaire   +5 more sources

Identification of a Four-Gene-Based SERM Signature for Prognostic and Drug Sensitivity Prediction in Gastric Cancer

Frontiers in Oncology, 2022
BackgroundGastric cancer (GC) is a highly molecular heterogeneous tumor with poor prognosis. Epithelial-mesenchymal transition (EMT) process and cancer stem cells (CSCs) are reported to share common signaling pathways and cause poor prognosis in GC ...
Xiya Jia, Xiya Jia, Bing Chen, Bing Chen, Ziteng Li, Ziteng Li, Shenglin Huang, Shenglin Huang, Siyuan Chen, Siyuan Chen, Runye Zhou, Runye Zhou, Wanjing Feng, Wanjing Feng, Hui Zhu, Hui Zhu, Xiaodong Zhu, Xiaodong Zhu   +17 more
doaj   +1 more source

A novel prognostic six‐CpG signature in glioblastomas [PDF]

CNS Neuroscience & Therapeutics, 2018
SummaryAimsWe aimed to identify a clinically useful biomarker using DNA methylation‐based information to optimize individual treatment of patients with glioblastoma (GBM).MethodsA six‐CpG panel was identified by incorporating genome‐wide DNA methylation data and clinical information of three distinct discovery sets and was combined using a risk‐score ...
Xiang Zhang, Marc Aubry, An An Yin, Lu Hua Zhang, Wei Zhang, Yu He Liu, Amandine Etcheverry, Amandine Etcheverry, Ya Long He, Jean Mosser, Nan Lu, Jill S. Barnholtz-Sloan   +11 more
openaire   +5 more sources

A Novel Gene Prognostic Signature Based on Differential DNA Methylation in Breast Cancer

Frontiers in Genetics, 2021
Background: DNA methylation played essential roles in regulating gene expression. The impact of DNA methylation status on the occurrence and development of cancers has been well demonstrated.
Chunmei Zhu, Shuyuan Zhang, Di Liu, Qingqing Wang, Qingqing Wang, Ningning Yang, Ningning Yang, Zhewen Zheng, Zhewen Zheng, Qiuji Wu, Qiuji Wu, Qiuji Wu, Yunfeng Zhou, Yunfeng Zhou, Yunfeng Zhou   +14 more
doaj   +1 more source