Results 11 to 20 of about 1,264,892 (364)

A Prognostic Gene Signature for Hepatocellular Carcinoma

Frontiers in Oncology, 2022
Hepatocellular carcinoma is the third most common cause of cancer-related deaths in China and immune-based therapy can improve patient outcomes. In this study, we investigated the relationship between immunity-associated genes and hepatocellular carcinoma from the prognostic perspective.
Rong Chen, Meng Zhao, Yanli An, Yanli An, Dongfang Liu, Qiusha Tang, Gaojun Teng   +6 more
openaire   +3 more sources

Integrated analysis of gene expression and DNA methylation datasets identified key genes and a 6-gene prognostic signature for primary lung adenocarcinoma

Genetics and Molecular Biology, 2021
Lung adenocarcinoma (LUAD) is the main subtype of non-small cell lung cancer with a poor survival prognosis. In our study, gene expression, DNA methylation, and clinicopathological data of primary LUAD were utilized to identify potential prognostic ...
Jing Meng, Lei Cao, Huifang Song, Lichun Chen, Zhiguo Qu   +4 more
semanticscholar   +1 more source

M2-like tumor-associated macrophage-related biomarkers to construct a novel prognostic signature, reveal the immune landscape, and screen drugs in hepatocellular carcinoma

Frontiers in Immunology, 2022
Background M2-like tumor-associated macrophages (M2-like TAMs) have important roles in the progression and therapeutics of cancers. We aimed to detect novel M2-like TAM-related biomarkers in hepatocellular carcinoma (HCC) via integrative analysis of ...
Xiao-Yu Qu, Xingyu Zhao, Kexin Lin, Na Wang, Xuezhi Li, Songbo Li, Luyao Zhang, Yongquan Shi   +7 more
semanticscholar   +1 more source

Identification of cuproptosis-related subtypes and development of a prognostic signature in colorectal cancer

Scientific Reports, 2022
Cuproptosis, a novel form of copper-mediated regulated cell death, participates in tumor progression. However, the role of cuproptosis-related genes (CRGs) in colorectal cancer (CRC) remains unclear.
Yan-Fei Huang, Dongzhi Yin, Lina Wu
semanticscholar   +1 more source

Identification of a novel signature based on unfolded protein response-related gene for predicting prognosis in bladder cancer

Human Genomics, 2021
Highlights 1. We first comprehensive investigated the expression, protein–protein interaction, and prognostic value of unfolded protein response-related gene in bladder cancer. 2.
Ke Zhu, Liu Xiaoqiang, Wen Deng, Gongxian Wang, Bin Fu   +4 more
doaj   +1 more source

Integrative Analysis Constructs an Extracellular Matrix-Associated Gene Signature for the Prediction of Survival and Tumor Immunity in Lung Adenocarcinoma

Frontiers in Cell and Developmental Biology, 2022
Background: Lung adenocarcinoma (LUAD) accounts for the majority of lung cancers, and the survival of patients with advanced LUAD is poor. The extracellular matrix (ECM) is a fundamental component of the tumor microenvironment (TME) that determines the ...
Lingyan Xiao, Qian Li, Yongbiao Huang, Zhijie Fan, Wan Qin, Bo Liu, Xianglin Yuan   +6 more
doaj   +1 more source

Construction and Validation of a Novel Pyroptosis-Related Four-lncRNA Prognostic Signature Related to Gastric Cancer and Immune Infiltration

Frontiers in Immunology, 2022
Increasing evidence has demonstrated that pyroptosis, a type of inflammatory programmed cell death, plays an important role in the pathogenesis and progression of gastric cancer. However, it remains unclear whether pyroptosis-related long non-coding RNAs
Zhengguang Wang, Lei Cao, Sitong Zhou, Jin Lyu, Yang Gao, Ronghua Yang   +5 more
semanticscholar   +1 more source

Prognostic Alternative Splicing Signatures in Esophageal Carcinoma

Cancer Management and Research, 2021
Alternative splicing (AS) is a method of increasing the number of proteins that the genome is capable of coding for, by altering the pre-mRNA during its maturation. This process provides the ability of a broad range of proteins to arise from a single gene. AS events are known to occur in up to 94% of human genes.
Zodwa Dlamini, Rodney Hull, Sikhumbuzo Z Mbatha, Mohammed Alaouna, You-Lin Qiao, Herbert Yu, Aristotelis Chatziioannou   +6 more
openaire   +5 more sources

Construction and Validation of Novel Diagnostic and Prognostic DNA Methylation Signatures for Hepatocellular Carcinoma

Frontiers in Genetics, 2020
Hepatocellular carcinoma (HCC) is one of the most prevalent life-threatening human cancers and the leading cause of cancer-related mortality, with increased global incidence within the last decade.
Ran Li, Liyan Shui, Junling Jia, Junling Jia, Chao Wu   +4 more
doaj   +1 more source

A novel pyroptosis-related prognostic signature for lung adenocarcinoma: Identification and multi-angle verification

Frontiers in Genetics, 2023
Background: Lung adenocarcinoma (LUAD) is an aggressive disease of heterogeneous characteristics with poor prognosis and high mortality. Pyroptosis, a newly uncovered type of programmed cell death with an inflammatory nature, has been determined to hold ...
Xinyue Wang, Xinyue Wang, Xinyue Wang, Jing Zhou, Jing Zhou, Jing Zhou, Zhaona Li, Zhaona Li, Zhaona Li, Xiuqiong Chen, Xiuqiong Chen, Xiuqiong Chen, Qianhui Wei, Qianhui Wei, Qianhui Wei, Kaidi Chen, Kaidi Chen, Kaidi Chen, Richeng Jiang, Richeng Jiang, Richeng Jiang   +20 more
doaj   +1 more source