Results 41 to 50 of about 1,466,359 (163)
Protein homeostasis in aging and cancer. [PDF]
Front Cell Dev Biol, 2023 Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis, or proteostasis, is a universal hallmark of both the aging process and cancer, a comprehensive understanding of the proteostasis system and its roles in aging and cancer will shed new light on how we can improve health and quality of life for older individuals ...
Chen XQ +5 more
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Protein folding, protein homeostasis, and cancer [PDF]
Chinese Journal of Cancer, 2011 Proteins fold into their functional 3-dimensional structures from a linear amino acid sequence. In vitro this process is spontaneous; while in vivo it is orchestrated by a specialized set of proteins, called chaperones. Protein folding is an ongoing cellular process, as cellular proteins constantly undergo synthesis and degradation. Here emerging links
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Frontiers in Oncology, 2021 Ubiquitin-Specific Peptidase 7 (USP7), or herpes virus-associated protease (HAUSP), is the largest family of the deubiquitinating enzymes (DUBs). Recent studies have shown that USP7 plays a vital role in regulating various physiological and pathological ...
Lin Zhou +6 more
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Lipid Homeostasis and Its Links With Protein Misfolding Diseases
Frontiers in Molecular Neuroscience, 2022 The maintenance of lipid homeostasis is essential for the normal functioning of living organisms. Alterations of the lipid homeostasis system remodel the composition of the lipidome, potentially leading to the formation of toxic lipid species.
Michele Vendruscolo
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Protein degradation and iron homeostasis
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012 Regulation of both systemic and cellular iron homeostasis requires the capacity to sense iron levels and appropriately modify the expression of iron metabolism genes. These responses are coordinated through the efforts of several key regulatory factors including F-box and Leucine-rich Repeat Protein 5 (FBXL5), Iron Regulatory Proteins (IRPs), Hypoxia ...
Thompson, Joel W., Bruick, Richard K.
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Cell Reports, 2016 Endophilin-A, a well-characterized endocytic adaptor essential for synaptic vesicle recycling, has recently been linked to neurodegeneration.
John D. Murdoch +12 more
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Lipid-anchored proteasomes control membrane protein homeostasis. [PDF]
Sci Adv, 2023 Protein degradation in eukaryotic cells is mainly carried out by the 26 S proteasome, a macromolecular complex not only present in the cytosol and nucleus but also associated with various membranes.
Zhang R +22 more
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Modulating protein–protein interaction networks in protein homeostasis [PDF]
Current Opinion in Chemical Biology, 2019 Protein-protein interactions (PPIs) occur in complex networks. These networks are highly dependent on cellular context and can be extensively altered in disease states such as cancer and viral infection. In recent years, there has been significant progress in developing inhibitors that target individual PPIs either orthosterically (at the interface) or
Mengqi Zhong +4 more
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Extracellular protein homeostasis in neurodegenerative diseases
Nature Reviews Neurology, 2023 The protein homeostasis (proteostasis) system encompasses the cellular processes that regulate protein synthesis, folding, concentration, trafficking and degradation. In the case of intracellular proteostasis, the identity and nature of these processes have been extensively studied and are relatively well known.
Wilson, Mark R +2 more
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Cell Reports, 2016 The balance between protein synthesis and protein breakdown is a major determinant of protein homeostasis, and loss of protein homeostasis is one of the hallmarks of aging.
Marieke Visscher +11 more
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