Results 1 to 10 of about 4,054 (130)

Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium. [PDF]

PLoS One, 2012
A mouse model with compromised mitochondrial fatty acid synthesis has been engineered in order to assess the role of this pathway in mitochondrial function and overall health.
Smith S, Witkowski A, Moghul A, Yoshinaga Y, Nefedov M, de Jong P, Feng D, Fong L, Tu Y, Hu Y, Young SG, Pham T, Cheung C, Katzman SM, Brand MD, Quinlan CL, Fens M, Kuypers F, Misquitta S, Griffey SM, Tran S, Gharib A, Knudsen J, Hannibal-Bach HK, Wang G, Larkin S, Thweatt J, Pasta S.   +27 more
europepmc   +20 more sources

FDX1 regulates cellular protein lipoylation through direct binding to LIAS. [PDF]

J Biol Chem, 2023
AbstractFerredoxins are a family of iron-sulfur (Fe-S) cluster proteins that serve as essential electron donors in numerous cellular processes that are conserved through evolution. The promiscuous nature of ferredoxins as electron donors enables them to participate in many metabolic processes including steroid, heme, vitamin D and Fe-S cluster ...
Dreishpoon MB, Bick NR, Petrova B, Warui DM, Cameron A, Booker SJ, Kanarek N, Golub TR, Tsvetkov P.   +8 more
europepmc   +4 more sources

Protein lipoylation in mitochondria requires Fe-S cluster assembly factors NFU4 and NFU5. [PDF]

Plant Physiol, 2022
Abstract Plants have evolutionarily conserved NifU (NFU)-domain proteins that are targeted to plastids or mitochondria. “Plastid-type” NFU1, NFU2, and NFU3 in Arabidopsis (Arabidopsis thaliana) play a role in iron–sulfur (Fe–S) cluster assembly in this organelle, whereas the type-II NFU4 and NFU5 proteins have not been subjected to ...
Przybyla-Toscano J, Maclean AE, Franceschetti M, Liebsch D, Vignols F, Keech O, Rouhier N, Balk J.   +7 more
europepmc   +9 more sources

Glycine decarboxylase maintains mitochondrial protein lipoylation to support tumor growth. [PDF]

Cell Metab, 2022
The folic acid cycle mediates the transfer of one-carbon (1C) units to support nucleotide biosynthesis. While the importance of serine as a mitochondrial and cytosolic donor of folate-mediated 1C units in cancer cells has been thoroughly investigated, a potential role of glycine oxidation remains unclear.
Mukha D, Fokra M, Feldman A, Sarvin B, Sarvin N, Nevo-Dinur K, Besser E, Hallo E, Aizenshtein E, Schug ZT, Shlomi T.   +10 more
europepmc   +3 more sources

Protein lipoylation: an evolutionarily conserved metabolic regulator of health and disease. [PDF]

Curr Opin Chem Biol, 2018
Lipoylation is a rare, but highly conserved lysine posttranslational modification. To date, it is known to occur on only four multimeric metabolic enzymes in mammals, yet these proteins are staples in the core metabolic landscape. The dysregulation of these mitochondrial proteins is linked to a range of human metabolic disorders.
Rowland EA, Snowden CK, Cristea IM.
europepmc   +4 more sources

Protein lipoylation in cancer: metabolic reprogramming and therapeutic potential. [PDF]

Cell Death Discov
Abstract Protein lipoylation, a mitochondria-specific post-translational modification (PTM) evolutionarily conserved from bacteria to mammals, plays critical role in metabolic processes. In humans, four identified lipoylated proteins serve as essential components of key enzymes involved in glycolysis, the tricarboxylic acid (TCA) cycle, and ...
Li S, Liu Y, Hu W, Deng A, Ren X, Chen L, Lu Y, Wu Y, Huang H, Cao J, Du J, Xia J, Li Y.   +12 more
europepmc   +3 more sources

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions. [PDF]

Cell Metab, 2016
Hypoxia-inducible transcription factors (HIFs) control adaptation to low oxygen environments by activating genes involved in metabolism, angiogenesis, and redox homeostasis. The finding that HIFs are also regulated by small molecule metabolites highlights the need to understand the complexity of their cellular regulation.
Burr SP, Costa AS, Grice GL, Timms RT, Lobb IT, Freisinger P, Dodd RB, Dougan G, Lehner PJ, Frezza C, Nathan JA.   +10 more
europepmc   +3 more sources

Engineered bacterial lipoate protein ligase A (lplA) restores lipoylation in cell models of lipoylation deficiency. [PDF]

J Biol Chem
Protein lipoylation, a vital lysine post-translational modification, plays a crucial role in the function of key mitochondrial tricarboxylic acid cycle enzymatic complexes. In eukaryotes, lipoyl post-translational modification synthesis occurs exclusively through de novo pathways, relying on lipoyl synthesis/transfer enzymes, dependent upon ...
Bick NR, Dreishpoon MB, Perry A, Rogachevskaya A, Bottomley SS, Fleming MD, Ducamp S, Tsvetkov P.   +7 more
europepmc   +3 more sources

Chemoselective and laser cleavable probes for <i>in situ</i> protein lipoylation detection by laser desorption/ionization mass spectrometry. [PDF]

Chem Sci
Chemoselective probe is connected with gold nanoparticles modified with laser cleavable mass tags by click chemistry for in situ protein lipoylation detection by laser desorption/ionization mass spectrometry.
Du Q, Yu X, Jia K, Qu Y, Han J, Sun J, Shen D, Liu H, Nie Z.   +8 more
europepmc   +3 more sources

Boosting energy metabolism and biosynthesis in diverse organisms by a common bacterial salvage lipoylation protein. [PDF]

Nat Commun
Yang R, Wang Y, Kong M, Hu Z, Zhang Z, Shen K, Meng J, Zeng AP.   +7 more
europepmc   +2 more sources