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Inhibitors of protein prenylation 2000
Expert Opinion on Therapeutic Patents, 2000The development of farnesyltransferase inhibitors (FTIs) was conceived of as a rational approach to the design of new cancer chemotherapeutics and the first examples of this class are currently being evaluated in Phase II and Phase III clinical trials.
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Structural analysis of prenylated proteins
1992Abstract The post-translational attachment of prenyl groups to proteins in eukaryotic cells has been recently reported (1-4). To date, two isoprenoid products derived from mevalonic acid (MVA), 15-carbon farnesyl groups or 20-carbon geranylgeranyl groups, have been detected.
Michael H Gelb +2 more
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Puzzling Promise Of Protein Prenylation
Chemical & Engineering News Archive, 1998From the ACS meeting Sometimes, you just get lucky, says Patrick J. Casey, associate professor of pharmacology and cancer biology at Duke University Medical Center. A case in point is the class of compounds that inhibits the enzyme farnesyltransferase. Designed to be anticancer drugs, the first of these compounds are entering trials in cancer patients.
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Prenylated Proteins in Peroxisome Biogenesis
2011Publisher Summary This chapter discusses the role of prenylated proteins in peroxisome biogenesis. Peroxisomes or microbodies are a family of functionally and structurally related organelles of eukaryotic cells. They are surrounded by a single lipid bilayer membrane and have a diameter of 0.1–1 μm.
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Acylation and prenylation of proteins
Current Opinion in Cell Biology, 1990R J, Deschenes, M D, Resh, J R, Broach
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Mechanisms, regulation and functions of the unfolded protein response
Nature Reviews Molecular Cell Biology, 2020Claudio Hetz +2 more
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